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Publications Blog

Read more at: A new LOPIT on the block

Example data demonstrating LOPIT-DC protein localisation classifications agree with those from hyperLOPIT.

A new LOPIT on the block

The Lilley Group have published a new paper in Nature Communications that combines the LOPIT-DC and hyperLOPIT spatial proteomics approaches.

Read more at: OOPS! A new method to capture the RNA-binding proteome!

RNA interactors in Escherichia coli identified by OOPS.

OOPS! A new method to capture the RNA-binding proteome!

The Lilley Group, and collaborators, have published a simple and cost-effective method to capture the RNA-binding proteome in Nature Biotechnology.

Read more at: Higher order from high disorder

Phase-separated dense liquid droplets formed from histone H1 C-terminal tail/DNA complexes, viewed under a microscope.

Higher order from high disorder

Katherine Stott and colleagues have published a new paper in PNAS that offers insight into the mechanism of DNA condensation and decondensation in eukaryotic cells.

Read more at: Reading the DNA book without opening it

Transcription factors can prefer one orientation over others when binding to nucleosomal DNA.

Reading the DNA book without opening it

The Taipale Group and their collaborators have published a paper in Nature that identifies five mechanisms by which proteins can read genetic information from the tightly packaged form of DNA found inside human cells.

Read more at: Evolutionary repurposing of a promiscuous enzyme

Cut-through representation of a P.aeruginosa arylsulfatase mutant, binding the newly evolved phosphonate monoester substrate.

Evolutionary repurposing of a promiscuous enzyme

The Hollfelder and Hyvönen labs have published a detailed molecular description of the chemistry at play during the evolution of a new function.