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Read more at: Evolutionary repurposing of a promiscuous enzyme

Cut-through representation of a P.aeruginosa arylsulfatase mutant, binding the newly evolved phosphonate monoester substrate.

Evolutionary repurposing of a promiscuous enzyme

The Hollfelder and Hyvönen labs have published a detailed molecular description of the chemistry at play during the evolution of a new function.

Read more at: A community approach for new experimental model systems

The choanoflagellate Salpingoeca rosetta expressing fluorescent proteins illuminating the cell body (green) and the plasma membrane (magenta)

A community approach for new experimental model systems

Dr Ross Waller, and collaborators from across the globe, have published a new paper in PLoS Biology describing a new community-based approach for developing model marine protists.

Read more at: Mismatch recognition by echinomycin may be harnessed for cancer detection

Crystal structure of the echinomycin–TT duplex

Mismatch recognition by echinomycin may be harnessed for cancer detection

Michael Waring, and collaborators in Taiwan, have published a new paper in the journal Nucleic Acids Research on the recognition of T:T mismatches by echinomycin.

Read more at: p53 impairs CRISPR/Cas9 in healthy cells

An artist's impression of DNA editing

p53 impairs CRISPR/Cas9 in healthy cells

The Taipale Group, and their collaborators, have published a new paper in Nature Medicine that may improve the efficiency of CRISPR in non-tumorigenic cells.

Read more at: A handful of transcription factors confer a hierarchical gene expression landscape

An artist's impression of a transcription factor binding to DNA

A handful of transcription factors confer a hierarchical gene expression landscape

The Taipale Group have published a new paper in Nature Biotechnology on the pattern of regulatory interactions involved in gene expression.