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The Department's buildings are currently open for wet laboratory work only. We have carried out a comprehensive COVID-19 risk assessment process and have introduced a number of new measures to ensure the safety of our staff, including reduced building occupancy, strict social distancing, 'family'-based working, and increased cleaning and hygiene regimes. All staff who can work remotely will do so for the foreseeable future. Please continue to contact us by email until further notice.

Department of Biochemistry

hRAD51-ATP filament

Macromolecular mechanisms of genome duplication and stability

The faithful inheritance of genetic information is essential to cellular life. Successful transmission of the genetic material requires the accurate replication of the genome and the repair of any DNA lesion that might block replication or alter the encoded message. Failure of the complex molecular systems that preserve the integrity of our DNA is a major contributing factor in human disease.

Our research aims to define structural and functional properties of proteins and protein complexes responsible for the maintenance and replication of our genome.  Our experimental approach involves the reconstitution in vitro of the biological system under investigation, which can then be subject to biochemical and biophysical analysis. We work on processes that pertain to both DNA repair and replication. Please consult our publication list for more information.

Our research is funded by the Wellcome Trust and the Medical Research Council.

Contact details

Research Group Leader  Luca Pellegrini​


Location  Sanger Building


The Pellegrini Group is accepting enquiries from prospective interns, undergraduate students, postgraduate students and postdoctoral researchers.