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The Department's buildings are currently open for wet laboratory work only. We have carried out a comprehensive COVID-19 risk assessment process and have introduced a number of new measures to ensure the safety of our staff, including reduced building occupancy, strict social distancing, 'family'-based working, and increased cleaning and hygiene regimes. All staff who can work remotely will do so for the foreseeable future. Please continue to contact us by email until further notice.

Department of Biochemistry

Jim Metcalfe

Transforming growth factor-beta signalling pathways.


Key publications

Kirschenlohr H, Ellis P, Hesketh R, Metcalfe J (2012). Gene expression profiles in white blood cells of volunteers exposed to a 50 Hz electromagnetic field. Radiat. Res., 178(3):138-149. doi: 10.1667/rr2859.1

Scollen S, Luccarini C, Baynes C, Driver K, Humphreys MK, Garcia-Closas M, Jonine F, Lissowska J, Pharoah PD, Easton DF, Hesketh R, Metcalfe JC, Dunning AM (2011). TGF-beta signaling pathway and breast cancer susceptibility. Cancer Epidemiol. Biomarkers Prev., 20(6):1112-1119. doi: 10.1158/1055-9965.EPI-11-0062

Oklü R, Hesketh R, Wicky S, Metcalfe JC (2011). Expression of mRNA isoforms of latent transforming growth factor-β binding protein-1 in coronary atherosclerosis and human tissues. Biochem. Genet., 49(3-4):213-225. doi: 10.1007/s10528-010-9400-x

Oklü R, Hesketh R, Wicky S, Metcalfe JC (2011). Localization of latent transforming growth factor-β binding protein-1 in human coronary atherosclerotic plaques. Circ. J., 75(1):196-200. doi: 10.1253/circj.cj-10-0334

Scollen S, Dunning AM, Bradshaw AC, Hesketh R, Metcalfe JC (2008). Association of gene variants in the TGF-beta signalling pathways with invasive breast cancer risk. Breast Cancer Res., 10(Suppl 2):P48. doi: 10.1186/bcr1932

Contact details

Research Group Leader  Jim Metcalfe



Jim Metcalfe is unable to accept enquiries from prospective students or staff.