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The Department's buildings are currently open for wet laboratory work only. We have carried out a comprehensive COVID-19 risk assessment process and have introduced a number of new measures to ensure the safety of our staff, including reduced building occupancy, strict social distancing, 'family'-based working, and increased cleaning and hygiene regimes. All staff who can work remotely will do so for the foreseeable future. Please continue to contact us by email until further notice.

Department of Biochemistry

 
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Chromatin and gene regulatory proteins.

 

Key publications

Thomas JO, Travers AA (2001). HMG1 and 2, and related 'architectural' DNA-binding proteins. Trends Biochem. Sci., 26(3):167-174. doi: 10.1016/s0968-0004(01)01801-1

Watson M, Stott K, Thomas JO (2007). Mapping intramolecular interactions between domains in HMGB1 using a tail-truncation approach. J. Mol. Biol., 374(5):1286-1297. doi: 10.1016/j.jmb.2007.09.075

Cato L, Stott K, Watson M, Thomas JO (2008). The interaction of HMGB1 and linker histones occurs through their acidic and basic tails. J. Mol. Biol., 384(5):1262-1272. doi: 10.1016/j.jmb.2008.10.001

Stott K, Watson M, Howe FS, Grossmann JG, Thomas JO (2010). Tail-mediated collapse of HMGB1 is dynamic and occurs via differential binding of the acidic tail to the A and B domains. J. Mol. Biol., 403(5):706-722. doi: 10.1016/j.jmb.2010.07.045

Thomas JO, Stott K (2012). H1 and HMGB1: Modulators of chromatin structure. Biochem. Soc. Trans., 40(2):341-346. doi: 10.1042/BST20120014

Contact details

Research Group Leader  Dame Jean Thomas

Email  jot1@cam.ac.uk

Opportunities

Dame Jean Thomas is unable to accept enquiries from prospective students or staff.