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Department of Biochemistry


Chromatin and gene regulatory proteins.


Key publications

Thomas JO, Travers AA (2001). HMG1 and 2, and related 'architectural' DNA-binding proteins. Trends Biochem. Sci., 26(3):167-174. doi: 10.1016/s0968-0004(01)01801-1

Watson M, Stott K, Thomas JO (2007). Mapping intramolecular interactions between domains in HMGB1 using a tail-truncation approach. J. Mol. Biol., 374(5):1286-1297. doi: 10.1016/j.jmb.2007.09.075

Cato L, Stott K, Watson M, Thomas JO (2008). The interaction of HMGB1 and linker histones occurs through their acidic and basic tails. J. Mol. Biol., 384(5):1262-1272. doi: 10.1016/j.jmb.2008.10.001

Stott K, Watson M, Howe FS, Grossmann JG, Thomas JO (2010). Tail-mediated collapse of HMGB1 is dynamic and occurs via differential binding of the acidic tail to the A and B domains. J. Mol. Biol., 403(5):706-722. doi: 10.1016/j.jmb.2010.07.045

Thomas JO, Stott K (2012). H1 and HMGB1: Modulators of chromatin structure. Biochem. Soc. Trans., 40(2):341-346. doi: 10.1042/BST20120014

Contact details

Research Group Leader  Jean Thomas



Jean Thomas is no longer able to accept enquiries from prospective students or staff; her laboratory has now closed.