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The Department's buildings are currently open for wet laboratory work only. We have carried out a comprehensive COVID-19 risk assessment process and have introduced a number of new measures to ensure the safety of our staff, including reduced building occupancy, strict social distancing, 'family'-based working, and increased cleaning and hygiene regimes. All staff who can work remotely will do so for the foreseeable future. Please continue to contact us by email until further notice.

Department of Biochemistry

 
Richard Farndale

Collagen receptors and collagen-binding proteins.

 

Key publications

Farndale RW, Lisman T, Bihan D, Hamaia S, Smerling CS, Pugh N, Konitsiotis A, Leitinger B, de Groot PG, Jarvis GE, Raynal N (2008). Cell-collagen interactions: The use of peptide toolkits to investigate collagen-receptor interactions. Biochem. Soc. Trans., 36(Pt 2):241-250. doi: 10.1042/BST0360241

Pugh N, Simpson AMC, Smethurst PA, de Groot PG, Raynal N, Farndale RW (2010). Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood. Blood, 115(24):5069-5079. doi: 10.1182/blood-2010-01-260778

Boilard E, Nigrovic PA, Larabee K, Watts GFM, Coblyn JS, Weinblatt ME, Massarotti EM, Remold-O'Donnell E, Farndale RW, Ware J, Lee DM (2010). Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science, 327(5965):580-583. doi: 10.1126/science.1181928

Barrow AD, Raynal N, Andersen TL, Slatter DA, Bihan D, Pugh N, Cella M, Kim T, Rho J, Negishi-Koga T, Delaisse J-M, Takayanagi H, Lorenzo J, Colonna M, Farndale RW, Choi Y, Trowsdale J (2011). OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J. Clin. Invest., 121(9):3505-3516. doi: 10.1172/JCI45913

Munnix ICA, Gilio K, Siljander PRM, Raynal N, Feijge MAH, Hackeng TM, Deckmyn H, Smethurst PA, Farndale RW, Heemskerk JWM (2008). Collagen-mimetic peptides mediate flow-dependent thrombus formation by high- or low-affinity binding of integrin alpha2beta1 and glycoprotein VI. J. Thromb. Haemost., 6(12):2132-2142. doi: 10.1111/j.1538-7836.2008.03167.x

Contact details

Research Group Leader  Richard Farndale

Email  rwf10@cam.ac.uk

Opportunities

Richard Farndale is unable to accept enquiries from prospective students or staff.