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Department of Biochemistry

 
Richard Farndale

Collagen receptors and collagen-binding proteins.

 

Key publications

Farndale RW, Lisman T, Bihan D, Hamaia S, Smerling CS, Pugh N, Konitsiotis A, Leitinger B, de Groot PG, Jarvis GE, Raynal N (2008). Cell-collagen interactions: The use of peptide toolkits to investigate collagen-receptor interactions. Biochem. Soc. Trans., 36(Pt 2):241-250. doi: 10.1042/BST0360241

Pugh N, Simpson AMC, Smethurst PA, de Groot PG, Raynal N, Farndale RW (2010). Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood. Blood, 115(24):5069-5079. doi: 10.1182/blood-2010-01-260778

Boilard E, Nigrovic PA, Larabee K, Watts GFM, Coblyn JS, Weinblatt ME, Massarotti EM, Remold-O'Donnell E, Farndale RW, Ware J, Lee DM (2010). Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science, 327(5965):580-583. doi: 10.1126/science.1181928

Barrow AD, Raynal N, Andersen TL, Slatter DA, Bihan D, Pugh N, Cella M, Kim T, Rho J, Negishi-Koga T, Delaisse J-M, Takayanagi H, Lorenzo J, Colonna M, Farndale RW, Choi Y, Trowsdale J (2011). OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J. Clin. Invest., 121(9):3505-3516. doi: 10.1172/JCI45913

Munnix ICA, Gilio K, Siljander PRM, Raynal N, Feijge MAH, Hackeng TM, Deckmyn H, Smethurst PA, Farndale RW, Heemskerk JWM (2008). Collagen-mimetic peptides mediate flow-dependent thrombus formation by high- or low-affinity binding of integrin alpha2beta1 and glycoprotein VI. J. Thromb. Haemost., 6(12):2132-2142. doi: 10.1111/j.1538-7836.2008.03167.x

Contact details

Research Group Leader  Richard Farndale

Email  rwf10@cam.ac.uk

Opportunities

Richard Farndale is unable to accept enquiries from prospective students or staff.