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The Department's buildings are currently open for wet laboratory work only. We have carried out a comprehensive COVID-19 risk assessment process and have introduced a number of new measures to ensure the safety of our staff, including reduced building occupancy, strict social distancing, 'family'-based working, and increased cleaning and hygiene regimes. All staff who can work remotely will do so for the foreseeable future. Please continue to contact us by email until further notice.

Department of Biochemistry


2014 | 2013 | 2012 | 2010 | 2008 | 2007 | 2006 | 2005 |

before 2005

[16] de la Roche, M., Ibrahim, A.E.K., Mieszczanek, J., Bienz, M. (2014) LEF1 and B9L shield beta-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors. Cancer research, 74 (5), 1495–1505. Abstract
[15] Yang, Y., de la Roche, M., Crawley, S.W., Li, Z., Furmaniak-Kazmierczak, E., Cote, G.P. (2013) PakB binds to the SH3 domain of Dictyostelium Abp1 and regulates its effects on cell polarity and early development. Molecular biology of the cell, 24 (14), 2216–2227. Abstract
[14] de la Roche, M., Rutherford, T.J., Gupta, D., Veprintsev, D.B., Saxty, B., Freund, S.M., Bienz, M. (2012) An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid. Nature communications, 3, 680. Abstract
[13] de la Roche, M., Tessier, S.N., Storey, K.B. (2012) Structural and functional properties of glycerol-3-phosphate dehydrogenase from a mammalian hibernator. The protein journal, 31 (2), 109–119. Abstract
[12] Metcalfe, C., Ibrahim, A.E.K., Graeb, M., de la Roche, M., Schwarz-Romond, T., Fiedler, M., Winton, D.J., Corfield, A., Bienz, M. (2010) Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer. Cancer research, 70 (16), 6629–6638. Abstract
[11] Mieszczanek, J., de la Roche, M., Bienz, M. (2008) A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription. Proceedings of the National Academy of Sciences of the United States of America, 105 (49), 19324–19329. Abstract

de la Roche, M., Worm, J., Bienz, M. (2008) The function of BCL9 in Wnt/beta-catenin signaling and colorectal cancer cells. BMC cancer, 8, 199. Abstract


de la Roche, M. and Bienz, M. (2007) Wingless-independent association of Pygopus with dTCF target genes. Current biology : CB, 17 (6), 556–561. Abstract


Crawley, S.W., de la Roche, M., Lee, S.-F., Li, Z., Chitayat, S., Smith, S.P., Cote, G.P. (2006) Identification and characterization of an 8-kDa light chain associated with Dictyostelium discoideum MyoB, a class I myosin. The Journal of biological chemistry, 281 (10), 6307–6315. Abstract

[7] de la Roche, M., Mahasneh, A., Lee, S.-F., Rivero, F., Cote, G.P. (2005) Cellular distribution and functions of wild-type and constitutively activated Dictyostelium PakB. Molecular biology of the cell, 16 (1), 238–247. Abstract
before 2005
[6] de la Roche, M., Lee, S.-F., Cote, G.P. (2003) The Dictyostelium class I myosin, MyoD, contains a novel light chain that lacks high-affinity calcium-binding sites. The Biochemical journal, 374 (Pt 3), 697–705. Abstract
[5] de la Roche, M., Smith, J.L., Rico, M., Carrasco, S., Merida, I., Licate, L., Cote, G.P., Egelhoff, T.T. (2002) Dictyostelium discoideum has a single diacylglycerol kinase gene with similarity to mammalian theta isoforms. The Biochemical journal, 368 (Pt 3), 809–815. Abstract
[4] de la Roche, M., Smith, J.L., Betapudi, V., Egelhoff, T.T., Cote, G.P. (2002) Signaling pathways regulating Dictyostelium myosin II. Journal of muscle research and cell motility, 23 (7-8), 703–718. Abstract
[3] de la Roche, M. and Côté, G.P. (2001) Regulation of Dictyostelium Myosin I and II. Biochimica et Biophysica Acta (BBA) - General Subjects, 1525 (3), 245–261. Abstract
[2] Lee, S.-F., Mahasneh, A., de la Roche, M., Cote, G.P. (1998) Regulation of the p21-activated Kinase-relatedDictyostelium Myosin I Heavy Chain Kinase by Autophosphorylation, Acidic Phospholipids, and Ca2+-Calmodulin. Journal of Biological Chemistry, 273 (43), 27911–27917. Abstract
[1] de la Roche, M., Shen, Z., Byers, D.M. (1997) Hydrodynamic properties of Vibrio harveyi acyl carrier protein and its fatty-acylated derivatives. Archives of biochemistry and biophysics, 344 (1), 159–164. Abstract




Contact details

Research Group Leader  Marc de la Roche​


Location  Sanger Building


The de la Roche Group is accepting enquiries from prospective interns, undergraduate students, postgraduate students and postdoctoral researchers.