Molecular assembly lines and combinatorial biosynthesis.
Key publications
Oliynyk M, Samborskyy M, Lester JB, Mironenko T, Scott N, Dickens S, Haydock SF, Leadlay PF (2007). Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338. Nat. Biotechnol., 25(4):447-453. doi: 10.1038/nbt1297
Hong H, Demangel C, Pidot SJ, Leadlay PF, Stinear T (2008). Mycolactones: Immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria. Nat. Prod. Rep., 25(3):447-454. doi: 10.1039/b803101k
Demydchuk Y, Sun Y, Hong H, Staunton J, Spencer JB, Leadlay PF (2008). Analysis of the tetronomycin gene cluster: Insights into the biosynthesis of a polyether tetronate antibiotic. Chembiochem, 9(7):1136-1145. doi: 10.1002/cbic.200700715
Peter Leadlay