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Publications Blog

Read more at: Effectiveness of antibiotics significantly reduced when multiple bugs present

Laboratory model of human airways.

Effectiveness of antibiotics significantly reduced when multiple bugs present

The Welch Group has found that much higher doses of antibiotics are needed to eliminate a bacterial infection of the airways when other microbes are present. Their study helps to explain why respiratory infections often persist in people with lung diseases such as cystic fibrosis despite treatment.

Read more at: Accelerating cancer drug development by targeting a DNA repair protein

Hotspot map of the DNA-PKcs ATP binding site with inhibitors docked in.

Accelerating cancer drug development by targeting a DNA repair protein

The Blundell Group and our Cryo-Electron Microscopy Facility have published in Nature an exciting breakthrough in understanding how cancer drugs targeting the DNA repair protein DNA-PKcs bind to their target.

Read more at: Swapping Spike genes may promote emergence and spread of new coronaviruses

Artist's impression of the SARS-CoV-2 (COVID-19) virus.

Swapping Spike genes may promote emergence and spread of new coronaviruses

A group of scientists from Cambridge, Greece and Belgium has discovered that the genome region of coronaviruses that specifies the viral Spike protein is highly unstable and mobile.

Read more at: 'GPS-like' strategies in proteomics

'GPS-like' strategies in proteomics

Josie Christopher and Kathryn Lilley, along with 13 authors from world-leading subcellular proteomics laboratories, have published a comprehensive review in Nature Reviews Methods Primers covering the major techniques in the field.

Read more at: Unwinding the secrets of the coronavirus genome, loop by loop

Unwinding the secrets of the coronavirus genome, loop by loop.

Unwinding the secrets of the coronavirus genome, loop by loop

Omer Ziv, with the Miska Group and collaborators, has uncovered how the genome of SARS-CoV-2 uses genome origami to infect and replicate successfully inside host cells. This could inform development of effective drugs that target specific parts of the virus genome, in the fight against COVID-19.