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Department of Biochemistry

 
Graphical abstract from the article

The HUSH complex preserves genome integrity through epigenetic silencing of invasive retroelements. A new study led by Josh Danac in the Tchasovnikarova lab now describes HUSH2, a related complex that instead represses interferon-stimulated genes. The cell exploits competition between HUSH and HUSH2 to couple retroelement silencing to the immune response, thereby bridging epigenetic and immune aspects of genome defense.

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Graphical abstract from the article

Authors

Joshua Miguel C. Danac, Rachael E. Matthews, Akhila Gungi, Chuyan Qin, Harriet Parsons, Robin Antrobus, Richard T. Timms, Iva A. Tchasovnikarova

Journal

Molecular Cell

Publication date

15 July 2024

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