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Department of Biochemistry

 
Surface representation of the HOXB13 transcription factor binding DNA.
Read more at: Higher order from high disorder
Phase-separated dense liquid droplets formed from histone H1 C-terminal tail/DNA complexes, viewed under a microscope.

Higher order from high disorder

Katherine Stott and colleagues have published a new paper in PNAS that offers insight into the mechanism of DNA condensation and decondensation in eukaryotic cells.


Read more at: Andras Solt wins Glover Research Award
Andras Solt in the laboratory.

Andras Solt wins Glover Research Award

Congratulations to Andras Solt on winning the Department's Glover Research Award for the 2018-2019 academic year.


Read more at: Second Year Postgraduate Poster Sessions 2018
Second Year Postgraduate Poster Sessions 2018 prize winners.

Second Year Postgraduate Poster Sessions 2018

The Department of Biochemistry's annual Second Year Postgraduate Poster Sessions were held on Wednesday 19th and Thursday 20th September.


Read more at: Reading the DNA book without opening it
Transcription factors can prefer one orientation over others when binding to nucleosomal DNA.

Reading the DNA book without opening it

The Taipale Group and their collaborators have published a paper in Nature that identifies five mechanisms by which proteins can read genetic information from the tightly packaged form of DNA found inside human cells.


Read more at: Evolutionary repurposing of a promiscuous enzyme
Cut-through representation of a P.aeruginosa arylsulfatase mutant, binding the newly evolved phosphonate monoester substrate.

Evolutionary repurposing of a promiscuous enzyme

The Hollfelder and Hyvönen labs have published a detailed molecular description of the chemistry at play during the evolution of a new function.


Image

Surface representation of the HOXB13 transcription factor binding DNA.

Credit: Ekaterina Morgunova, Karolinska Institute.