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Publications Blog

Read more at: Higher order from high disorder

Phase-separated dense liquid droplets formed from histone H1 C-terminal tail/DNA complexes, viewed under a microscope.

Higher order from high disorder

Katherine Stott and colleagues have published a new paper in PNAS that offers insight into the mechanism of DNA condensation and decondensation in eukaryotic cells.

Read more at: Reading the DNA book without opening it

Transcription factors can prefer one orientation over others when binding to nucleosomal DNA.

Reading the DNA book without opening it

The Taipale Group and their collaborators have published a paper in Nature that identifies five mechanisms by which proteins can read genetic information from the tightly packaged form of DNA found inside human cells.

Read more at: Evolutionary repurposing of a promiscuous enzyme

Cut-through representation of a P.aeruginosa arylsulfatase mutant, binding the newly evolved phosphonate monoester substrate.

Evolutionary repurposing of a promiscuous enzyme

The Hollfelder and Hyvönen labs have published a detailed molecular description of the chemistry at play during the evolution of a new function.

Read more at: A community approach for new experimental model systems

The choanoflagellate Salpingoeca rosetta expressing fluorescent proteins illuminating the cell body (green) and the plasma membrane (magenta)

A community approach for new experimental model systems

Dr Ross Waller, and collaborators from across the globe, have published a new paper in PLoS Biology describing a new community-based approach for developing model marine protists.

Read more at: Mismatch recognition by echinomycin may be harnessed for cancer detection

Crystal structure of the echinomycin–TT duplex

Mismatch recognition by echinomycin may be harnessed for cancer detection

Michael Waring, and collaborators in Taiwan, have published a new paper in the journal Nucleic Acids Research on the recognition of T:T mismatches by echinomycin.