skip to content

 

The Department's buildings are currently open for wet laboratory work only. We have carried out a comprehensive COVID-19 risk assessment process and have introduced a number of new measures to ensure the safety of our staff, including reduced building occupancy, strict social distancing, 'family'-based working, and increased cleaning and hygiene regimes. All staff who can work remotely will do so for the foreseeable future. Please continue to contact us by email until further notice.

Department of Biochemistry

 
Department of Biochemistry news archive

The Gay Group and collaborators have published a paper in PNAS.

 

Nick Gay and his collaborators have published a paper in PNAS entitled "Cytokine Spätzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation". The ability of organisms to detect and respond to infection by microorganisms is fundamental and has ancient evolutionary origins. In mammals, immune system cells recognize danger molecules directly using pattern recognition receptors which often belong to the Toll family. In insects, it has been found that Gram-positive bacteria and fungi can also be detected indirectly by an endogenous molecule, Spätzle (Spz), that activates related Toll receptors, leading to an effective immune response. In this work, the group has determined the molecular structure of a Spz/Toll complex, which reveals that Spz's mode of action is similar to neurotrophins, a family of proteins involved in the development and homeostasis of the insect and vertebrate nervous systems.

Author

Jenny Barna

Publication date

19 November 2013