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Department of Biochemistry

 
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Current jobs in the Department of Biochemistry at the University of Cambridge.
Updated: 9 min 14 sec ago

Senior Secretary (Fixed Term)

Thu, 11/02/2021 - 00:00

Applications are invited for a Personal Assistant in the Department of Biochemistry, supporting the research group of Professor Jussi Taipale, Herchel Smith Professor of Biochemistry. The group includes both experimental biologists and computer scientists, and is currently composed of seven postdoctoral fellows.

The role requires the ability to communicate effectively with a wide range of people within the department, broader University and externally, particularly collaborators and funding bodies. Typical activities include the management and organization of international travel, expense administration, coordinating grant applications and subsequent reporting, letter writing and diary management. You will work closely with departmental administration teams including Human Resources, Finance and Procurement on behalf of the research group.

The successful applicant must have excellent communication and organizational skills and be used to working to tight deadlines with attention to detail. The ability to prioritize and plan your own workload independently is essential, in addition to being flexible and able to work on your own initiative within agreed boundaries. An interest in website design and content management would be desirable.

Ideally candidates will be educated to degree level (or equivalent) and have experience working as a PA and facilitator. Previous experience of working in a higher education institution would be advantageous.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Informal enquires can be made by contacting Dr Minna Taipale, email: mt779@cam.ac.uk. For any enquiries relating to the application process, please contact the Biochemistry HR team; +44 1223 333617, email; personnel@bioc.cam.ac.uk.

Further information on the Taipale lab can be obtained at https://www.bioc.cam.ac.uk/research/uto/taipale

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have questions about the application process please email personnel@bioc.cam.ac.uk

Please quote reference PH25654 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

AstraZeneca PhD Studentship (Fixed Term)

Wed, 10/02/2021 - 00:00

Characterisation of secretion of engineered monoclonal antibodies from CHO cells

A fully funded 4-year BBSRC-CTP Industrial CASE PhD studentship is available, commencing on 1st October 2021, to investigate host cell-AAV (adeno-associated virus) interactions that can be optimized to intensify AAV manufacture of difficult to express serotypes. The aim of the BBSRC-CTP awards is to provide PhD students with a first class training experience both in academic and non-academic partner organizations. This project is partnered by AstraZeneca (AZ), a world-leading company specializing in antibody, vector delivery for gene therapy and peptide therapeutics. The work will make use AZ's considerable experience in developing AAV's at scale suitable for both clinic and market supply.

AAV is a small parvovirus composed of a capsid, which can be engineered to act as a vector delivery system for gene therapy or to enable in vivo expression of biologics. The development of efficient manufacturing processes capable of producing AAV at scale is still in its infancy. One challenge is the apparent serotype-dependent poor expression in human cell lines.

The project seeks to better understand the fundamental mechanisms involved in AAV secretion, especially where secretion is impaired. Identification of proteins that change their expression and/or location in cells expressing easy/hard to express AAV serotypes is of vital importance in generating cell lines for clinical supply of delivery systems for gene therapy and immunotherapy.

The student will employ a multi-omics approach to characterize AAV-cell interactions, using novel spatial proteomics methods developed by Professor Kathryn Lilley's group (http://proteomics.bio.cam.ac.uk/), that accurately locate proteins to subcellular structures on a proteome wide scale 1,2. These data will be integrated with whole proteome and transcriptome analysis from the same serotypes. Cutting-edge high resolution imaging will also be used for data validation.

The successful candidate will be jointly supervised by Prof. Lilley, in the Dept. of Biochemistry, University of Cambridge and a supervisory team at AZ, soon to be located at the Cambridge Biomedical Campus. Further details of our PhD program can be found at https://www.bioc.cam.ac.uk/graduate/new-graduates.

Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject.

Funding: A stipend (currently £17000 pa) will be provided for up to 4 years. This funding covers the University Composition Fee (Home fees rate) and Maintenance and consumables. The studentship is open to UK citizens or EU students who meet the UK residency requirements for Home fees, and international (including EU) candidates able to provide the difference in Home and Overseas fees from other sources. For further information see: http://www.graduate.study.cam.ac.uk/finance/fees/what-my-fee-status.

Application: Please e-mail Prof. Lilley (k.s.lilley@bioc.cam.ac.uk) with following information by 20th March 2021: CV (max two pages), with full contact details of 2 academic referees and a covering letter (max two pages) highlighting (a) your research interests (b) what you hope to achieve from the programme, (c) your career aspirations (d) why you wish to undertake this PhD.

Also, please apply to the University by the above deadline using the Applicant Portal: http://www.graduate.study.cam.ac.uk/how-do-i-apply. Fully completed applications. Please search in the Course Directory for "Biochemistry" PhD studentships.

NOTE: you must complete the 'Research Summary' section of the University application form.

Please direct any questions to the Graduate Admissions Administrator at pg-entry@bioc.cam.ac.uk. The University values diversity and is committed to equality of opportunity. 1. Geladaki A, Nature Commun. 2019. doi: 10.1038/s41467-018-08191-w 2. Christophorou A, Nature Commun. 2016 doi: 10.1038/ncomms9992.

If you have questions about the application process please email personnel@bioc.cam.ac.uk

Please quote reference PH25650 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant (Fixed Term)

Mon, 08/02/2021 - 00:00

An application is invited for one Research Assistant position that has become available in the Department of Biochemistry of the University of Cambridge, UK.

The successful applicant will work to support the research activity of the laboratories of Profs. Pellegrini and Luisi. This will include assisting researchers with their experiments, maintaining stocks of reagents, consumables and small equipment items etc. A smaller portion of the time will also be dedicated to work supporting the Structural Biology Research Facilities of the Department.

This is a challenging but rewarding position that would suit an ambitious recent graduate in Biochemistry, Biology or related discipline, who is keen to gain experience in an active research environment.

The ideal candidate will combine an ability to multi-task and to fit in well in a team. Excellent communication and time-management skills are essential for the role. Experience with basic biochemistry and molecular biology techniques would be highly desirable, although training will be provided.

Applicants should submit a CV citing relevant experience, a cover letter explaining why they are suitable for the position and contact information for at least two referees.

Fixed-term: The funds for this post are available for 60 months in the first instance.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have questions about the application process please email personnel@bioc.cam.ac.uk

Please quote reference PH25600 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate x 3 (Fixed Term)

Mon, 08/02/2021 - 00:00

Applications are invited for three Research Associate positions that have become available in the laboratory of Prof. Luca Pellegrini in the Department of Biochemistry of the University of Cambridge, UK.

Work in the laboratory is focused on elucidating the structural basis for eukaryotic DNA replication (Rzechorzek et al, NAR, 2020; Evrin et al, EMBOJ, 2018; Villa et al, Mol Cell, 2016; Simon et al, Nat Comm, 2016; Simon et al, Nature, 2014) and associated DNA repair processes (Lerner et al, EMBOJ, 2020; Brouwer et al, EMBOJ, 2018).

The aim of the project is to elucidate key molecular mechanisms of DNA synthesis by the human replisome, the dynamic multi-protein ensemble responsible for duplicating chromosomal DNA before cell division. To achieve this goal, the successful candidates will use a multi-disciplinary approach that includes preparative biochemistry of multi-protein complexes, protein engineering and state-of-the-art biophysical and structural techniques.

The project will advance our understanding of how our cells copy their DNA and thus maintain genomic stability across cellular generations. In addition to its biological importance, such information will have great medical relevance, as disease such as cancer and premature aging are promoted by errors in our genome caused by defective replication.

Successful candidates will hold or be about to be awarded a PhD in Biochemistry, Biophysics or Molecular Biology. They must have a track record in conducting internationally competitive research, including peer-reviewed publications as first author.

The ideal candidate will combine an ability to work independently and to fit in well in a team. Above all, she/he will be enthusiastic about pursuing fundamental research and be highly motivated to succeed professionally.

Expert knowledge of modern methods of preparative biochemistry and/or of quantitative biophysical methods is required. In particular, expertise in one or more of the following techniques is essential: - Mammalian/insect-cell protein expression, - cryoEM (SPA and/or tomography), - single-molecule fluorescence analysis

Applicants should submit a CV with list of relevant publications, a cover letter explaining why they are suitable for the position and contact information for at least two referees.

Fixed-term: The funds for this post are available for 60 months in the first instance.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have questions about the application process please email personnel@bioc.cam.ac.uk

Please quote reference PH25609 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Grants Assistant (Fixed Term)

Wed, 27/01/2021 - 00:00

The Department of Biochemistry is seeking an enthusiastic Research Grants Assistant to join its very busy research grant team.

The role is to administer the end to end support for a portfolio of grants, working closely with grant holders, funders and internal University offices. Specifically the main responsibilities include monitoring grant budgets on a monthly basis; producing budget expenditure analyses; staff forecasting; raising grant applications on the internal costing system; interrogating and using the University Finance System to process grant transactions.

The ideal candidate will be used to working in a busy environment whilst maintaining high levels of accuracy. Previous experience of working in a financial and/or a research grant administration role, using computerised financial accounting systems and spreadsheets is desirable. Strong computing, willingness to learn and communication skills are essential. Educated to 'A' level standard with an AAT qualification is desirable.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment. Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have questions about the application process please email personnel@bioc.cam.ac.uk

Please quote reference PH25515 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Receptionist/Clerical Assistant

Tue, 26/01/2021 - 00:00

A vacancy has arisen within the Departmental Secretariat.

Reporting to the Secretariat Supervisor, the successful candidate will be expected to provide ad-hoc administrative support to research groups and facilities within the Department, including but not limited to accounts and the library. In addition, and as part of the Departmental Secretariat Team, they be expected to assist in providing cover and support to both the Hopkins and Sanger Receptions, acting as the first point of contact for visitors. Whilst covering Reception, the successful candidate will be expected to answer and transfer telephone calls, circulate and respond to emails, sort and distribute post, issuing access cards and keys and respond to requests and queries from members of the Department. The successful candidate will also provide support to the Fire Manager during the fire evacuation procedure and inform senior members of the Department of any security related concerns.

The ideal candidate will have a good general education (GCSE standard including English and Maths), be prepared to work on their own initiative, have the ability to prioritise their work, be well organised, flexible in their approach and have excellent communication and IT skills.

If you have any questions about this vacancy please contact Debbie Canham (dac77@cam.ac.uk) or Sarah Gordon (Sg953@cam.ac.uk). If your questions relate to the application process, please contact the Departmental Human Resources Team (personnel@bioc.cam.ac.uk).

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have questions about the application process please email personnel@bioc.cam.ac.uk

Please quote reference PH25507 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

Mon, 18/01/2021 - 00:00

Applications are invited for a Postdoctoral Research Associate position at the University of Cambridge, Department of Biochemistry, central Cambridge, working in the laboratory of Jussi Taipale, Herchel Smith Professor of Biochemistry. The focus of the work in the laboratory is aimed at understanding how DNA sequences determine where and when genes are expressed (see Yin et al., Science 2017; Wei et al. Nature Biotechnology, 2018; Zhu et al., Nature 2018; Jolma et al., Genome Res. 2020; Yan et al., Nature, in press), and how mutations and inherited sequence variation cause deregulated transcription and tumourigenesis (see Sur et al., Science 2012; Dave et al, eLife 2017). The group's research will have an impact on both the fundamental understanding of the regulation of gene expression, and on knowledge of the mechanisms that control cell growth during normal development and in pathologies such as cancer.

As part of the phased development of the Taipale group in Cambridge, a position is available for a Post-doctoral Research Associate studying basic mechanisms of gene regulation in human normal and tumorigenic cells using a combination of experimental and computational strategies, including high throughput biochemical assays and functional genomics approaches combined with genome engineering.

The main duties will involve designing, performing and analysing genome-scale experiments to understand basic mechanisms of transcription, and the role of gene regulation and cellular signalling pathways in growth regulation and inheritance of cancer risk. The successful candidates should have (or be close to completing) a PhD in one of the following: Genetics, Biochemistry, Systems Biology, Computational Biology, Medicine or a related field.

Applicants with experience and/or interest in developing their skills in both experimental and computational approaches, who have (co)first author publications or work completed for publication would be preferred. Applicants interested in the above research area and/or interested in developing a novel research direction will be considered. The duration of the appointment is negotiable.

The selection process will be conducted in early 2021 and the post is available immediately thereafter. The funds for this post are available for 24 months in the first instance.

To apply online, please visit https://www.jobs.cam.ac.uk/job/27622/ and register an account with our recruitment system.

Any enquiries relating to the application process, please contact the Biochemistry HR team; +44 1223 333617, email; personnel@bioc.cam.ac.uk

Informal enquires can be made by contacting Dr Minna Taipale, email: mt779@cam.ac.uk; further information on the Taipale lab can be obtained at https://www.taipalelabs.org/ and https://www.bioc.cam.ac.uk/research/taipale Please quote reference PH24689 on your application and in any correspondence about this vacancy.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have questions about the application process please email personnel@bioc.cam.ac.uk

Please quote reference PH24689 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.