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The Department's buildings are currently open for wet laboratory work only. We have carried out a comprehensive COVID-19 risk assessment process and have introduced a number of new measures to ensure the safety of our staff, including reduced building occupancy, strict social distancing, 'family'-based working, and increased cleaning and hygiene regimes. All staff who can work remotely will do so for the foreseeable future. Please continue to contact us by email until further notice.

Department of Biochemistry

 
Richard Jackson

Mechanisms of translation initiation site selection in eukaryotic and viral mRNA.​

 

Key publications

Jackson RJ (2013). The current status of vertebrate cellular mRNA IRESs. Cold Spring Harb. Perspect. Biol., 5(2):a011569. doi: 10.1101/cshperspect.a011569

Pöyry TA, Kaminski A, Connell EJ, Fraser CS, Jackson RJ (2007). The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation. Genes Dev., 21(23):3149-3162. doi: 10.1101/gad.439507

Kafasla P, Morgner N, Pöyry TA, Curry S, Robinson CV, Jackson RJ (2009). Polypyrimidine tract binding protein stabilizes the encephalomyocarditis virus IRES structure via binding multiple sites in a unique orientation. Mol. Cell, 34(5):556-568. doi: 10.1016/j.molcel.2009.04.015

Kafasla P, Morgner N, Robinson CV, Jackson RJ (2010). Polypyrimidine tract-binding protein stimulates the poliovirus IRES by modulating eIF4G binding. EMBO J., 29(21):3710-3722. doi: 10.1038/emboj.2010.231

Pöyry TA, Jackson RJ (2011). Mechanisms governing the selection of translation initiation sites on foot-and-mouth disease virus RNA. J. Virol., 85(19):10178-10188. doi: 10.1128/JVI.05085-11

Contact details

Research Group Leader  Richard Jackson

Email  rjj1000@cam.ac.uk

Opportunities

Richard Jackson is unable to accept enquiries from prospective students or staff.