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Projects- examples of previous topics

Dr P Holliger (MRC-LMB)

Expanding substrate and template specificities of DNA polymerases by rational protein engineering

Dr R W Broadhurst
DANGLE: Predicting protein dihedral angles from chemical shift data

Dr M Mishima
Screening for mutants of CYK4 which suppress SPD1 mutant phenotypes using yeast two hybrid analysis

Dr L Pellegrini
Analysis of the interaction of the yeast Dpb11 protein with Sld2 and Sld3 phosphopeptides

Dr N Murzina
Characterising the interaction between Heterochromatin Protein 1 Alpha and Histone H3

Dr J Mata
The Schizosaccharomyces pombe Mei2 RNA-binding protein: roles in induction and progression of meiosis

Dr B F Luisi
RNA degradosome and ribosome interactions in Escherichia coli

Professor C J Howe
Variation of chloroplastic minicircular non-coding DNA in the dinoflagellates symbiodinium

Dr B Hendrich
MBD3/NuRD in neural development in vivo

Professor P F Leadlay
Investigating the activity of a putative dehydratase domain within the lankacidin polyketide synthase gene cluster

Professor J O Thomas
The interaction of the acidic tail of HMGB1 with the N-terminal tail of the core histone H3

Dr S Lummis
Investigating the effect of Cys-loop replacement on the solubility of the 5-HT3 receptor extracellular domain

Professor C W J Smith
Minigene reporter constructs as models of PTB-activated alternative splicing

Professor S Jackson
Cdk-mediated phosphorylation of Lif1 regulates non-homologous end joining in Saccharomyces cerevisiae

Dr H-J Hong
Characterisation of a VanJ-like gene in Streptomyces avermitilis

Dr A Grace
Optimisation of western blotting and its application in determining cardiac Na+ expression in a Murine model of Brugada Syndrome

Professor R W Farndale
Structural basis of collagen-GpVI interaction

Professor S Oliver
Construction of humanized and prorozoaized yeast strains for drug design

Professor K M Brindle
Effects of cell growth dynamics on the metabolic incorporation of sugar analogues into glycans and their implications for molecular imaging of tumour progression

Dr R Fitzgerald (Oncology)
Identifying biomarkers for Barrett’s oesophagus; a two fold approach to develop screening

Dr A P Jackson
An investigation into aggregation of a chicken B lymphocyte cell line temperature sensitive for clathrin

Dr M Welch
An investigation of the role of polyphosphate on the virulence of Erwinia carotovora spp. atroseptica

Professor N J Gay
Characterisation of a Mal (MyD88 adaptor-like) SNP involved in loss-of-function in the TLR signalling pathway

Professor R W Farndale
Phosphatidyl serine exposure, microparticles, and macroparticles

Professor A Smith
Investigating effects of hypoxia on embryonic stem cell self-renewal and differentiation

Dr M Hyvonen
Basis of nucleotide specificity in ATPase domain of pyrococcus furiosus RadA

Professor A Smith
Generation of anterior endoderm from EpiSCs

Dr A Tunnacliffe (Biotechnology)
Testing molecular shield function using amyloidogenic Aβ42 peptide associated with Alzheimer’s disease

Dr A Betz (MRC-LMB)
Functional characterization of the Foxp3 proline-rich domain in regulatory T cells

Dr S Lummis
Towards solving the crystal structure of the serotonin type 3 receptor

Professor T L Blundell
Structural features of hotspots in protein-protein interactions

Dr J McCafferty
Screening a set of anti-D114 (Delta-like 4) antibodies for their ability to block the interaction between D114 and Notch-1

Professor E D Laue
Determining the preferred substrate sequence of JMJD2A and the human and Saccharomyces pombe LSD1 lysine demethylase enzymes

Dr H Laman (Pathology)
Generation of a Jurkat cell line capable of inducible Fbxo7 knockdown

Dr G C Brown
The role of uric acid and an anti-inflammatory molecule in inflammatory neurodegeneration and primary phagocytosis

Dr L Pellegrini
Bioinformatic and biochemical characterization of folliculin

Dr M Higgins
ICAM1 binds the DBLβ-C2 domains of Plasmodium falciparum erythrocyte membrane protein 1 with nanomolar affinity, and this is not strongly inhibited by (-) –epigallocatechin gallate

Professor P F Leadlay
Characterisation of the biosynthetic gene cluster for salinomycin: an ionophoric polyether inhibitor of cancer stem cells

Professor M Field
Characterisation of RING-CH/MARCH family proteins in Trypanosoma brucei

Dr H R Mott
Expression and purification of C-terminally truncated RLIP76, investigation of structure and possible interaction wth ENTH

Professor E D Laue
Structural studies of the interaction between human PCNA and a noncanonical PCNA-interacting peptide of CAF-1, using X-ray crystallography

Dr E Miska
Transgenerational inheritance of RNAi-induced gene silencing in Caenorhabditis elegans