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The Lab

Darerca and Helen have worked together since 1997, when we were both post-docs in Cambridge. Since 2004 we have held permanent positions in the Department of Biochemistry, University of Cambridge. Darerca is a molecular biologist and protein chemist and Helen is a protein NMR specialist. We bring our combination of skills to all of the projects that we run.

Here we are at a FASEB meeting in 2000 with the best licence plate on a rental car we could find!

Darerca Owen

Darerca's first degree was in Genetics and she followed this with a PhD in Genetics in Peter Strike's lab at the University of Liverpool. She was then a post-doc at the Institute for Cancer Studies, University of Birmingham, where she became interested in cell signalling and small G proteins. She then moved to the University of Cambridge and was a post-doc there before being appointed as an Assistant Director of Research.

Helen Mott

Helen's first degree was in Biochemistry and she followed this with a PhD in Biochemistry in Iain Campbell's lab at the University of Oxford. She was then a post-doc at the University of North Carolina at Chapel Hill, where she began working on small G proteins. She moved to the University of Cambridge and held two MRC Fellowships before being appointed as an Assistant Director of Research.

 

Lab Members

Jemima photo Dr Jemima Thomas (2013-current): Jemima has a degree in Chemistry from Oxford and a PhD from Edward Tate's lab at Imperial College London. She followed this with a post-doc with Alessio Ciulli in Cambridge. Jemima is a biological chemist who is interested in modulating protein-protein interactions. She works on the RLIP76 project and is funded by the Cambridge Cancer Centre.
Tim photo Dr Timothy Sendall (2012-current): Tim has a degree in Biology from Nottingham and a PhD from Jim Huntington's lab in Cambridge. Tim is a biochemist and molecular biologist who works on the RLIP76 project and is funded by the MRC
Jo Picture Joanna Woods (2011-current): Jo came to us as an undergraduate project student and stayed on to do a PhD. She is funded by the Herchel Smith studentship. Jo is a budding structural biologist and works on Cdc42 effectors involved in actin cytoskeleton and endocytosis.
Lira photo Lira Puebla (2011-current): Lira has degrees in Chemistry from Universidad Autonoma de Madrid and Universidad de Castilla-Lamanchain Spain. She first came to Cambridge in 2010 as an Erasmus student. She was funded by Funcacion Caja Madrid at the start of her PhD and is now funded by a Research Scholarship from St Johns. Lira is particularly interested in NMR and is working on domains of the ACK tyrosine kinase.
Arooj photo Arooj Shafiq (2011-current): Arooj has a degree in Biochemistry from the University of Lahore in Pakistan. She is funded by the Pakistani Higher Education Commission and the Cambridge Commonwealth Trust. Arooj is using NMR during her PhD. She works on Ral proteins and is investigating their structure, dynamics and interactions.
Natasha photo Natasha Clayton (2011-current): Natasha has a degree in Physiology from the University of Leicester. She is funded by the BBSRC. She is an expert in tissue culture and protein-protein interactions and is working on the protein tyrosine kinase ACK1 and its targets.

Past Members

Karthik photo Dr Karthik Rajasekar (2008-2011): Karthik has a degree in Industrial Biotechnology from Anna University, Chennai and a PhD from Eva Hyde's lab in Birmingham. He is a structural biologist who also has an interest in biophysical techniques. Karthik is currently a post-doc with Prof Colin Kleanthous in Oxford.
Lou Campbell photo Louise Campbell (2001-2011): Lou has a degree in Biochemistry from the University of Leicester. She is a research assistant whose main interests lie in protein chemistry and the analysis of protein interactions. Lou is currently taking a career break to bring up her family.
Cat photo Dr Catherine Hutchinson (2005-2011): Cat came to us as an undergraduate project student and stayed to pursue a PhD funded by BBSRC. She is interested in protein interactions. During her time with us she worked on the Rho family and its coiled-coil effector proteins. She is currently working at PhiloChem in Otelfingen, Switzerland.
Mike Davies photo Michael Davies (2010-2011): Mike was an undergraduate project student who worked on Cdc42/effector interactions. He went to work in finance.
Millie Godlee photo Camilla Godlee (2010-2011): Millie was an undergraduate project student who worked on interactions between ACK1 and other proteins. She went to be a PhD student at EMBL (Heidelberg) in Marko Kaksonen's group.
Kadalmani photo Dr Kadalmani Krishnan (2006-2010): Kadalmani was a PhD student who worked on interactions between the ACK1 tyrosine kinase and signalling proteins. His expertise lies in mammalian cell culture, western blotting and kinase assays. Kadalmani is currently a post-doc at Harvard Medical School with Spyros Artavanis-Tsakonas.
Laura photo Dr Laura Bailey (2005-2010): Laura was a BBSRC-funded PhD student who solved the structure of the Arl2 effector BART (published in 2009) and investigated its interactions with Arl2 and Arl3. Laura is currently working at the Paul Scherrer Insitute in Switzerland.
Courtney photos Courtney Schroeder (2009-2010): Courtney was a Churchill Scholar and MPhil student who worked on interactions between the ACK1 tyrosine kinase and other molecules. Courtney is currently pursuing a PhD in San Francisco (UCSF).
Nicola Darling photo Nicola Darling (2009-2010): Nicola was an undergraduate project student who worked on interactions between ACK1 and other signalling proteins. Nicola is currently pursuing a PhD at the Babraham Institute with Simon Cook.
Bryn Fenwick photo Dr R. Brynmor Fenwick (2004-2009): Bryn came from New Zealand to do a PhD with us, funded by the Cambridge Overseas Trusts. He solved the structures of the Ral binding domain of RLIP76 (RalBP1) and its complex with RalB (published 2010. Bryn is currently a post-doc with Peter Wright at the Scripps Institute.
pepe photo Dr José Vicente Garcia (2004-2008): Pépé was a PhD student who was funded by a BBSRC Case studentship with GlaxoSmithKline. Pépé started off most of the work on ACK1 interactions in the lab. Originally from Galacia in Northern Spain, he is now settled in Cambridge and is a clinical research consultant.
Jordan Clay photo Jordan Clay (2007-2008): Jordan was an undergraduate project student who worked on IQGAP while he was in the lab. He went on to do a DPhil in Oxford with Radu Aricescu.
Sunil photo Dr Sunil Prasannan (2004-2007): Sunil was a post-doc funded by Cancer Research UK. He worked on exocyst and the RalB project and was involved in solving the structure of RalB, published in 2009. After a post-doc at NIMR in Mill Hill, he went to do a post-doc in Boulder, Colorado with Hang Yin.
keily photo Keily Littlefield (2005-2007):Keily was a research assistant funded by Cancer Research UK. She worked on interactions involving the Rho family, including IQGAP (published in 2008). She is now living in Cornwall where she runs the teaching labs at Truro College.
Rakhee photo Dr Rakhee Modha (2001-2005): Rakhee was an MRC-funded PhD student who worked on the structure of Rac1 in complex with the HR1b domain from PRK1. This was published in 2008 and was selected as paper of the week in JBC. Rakhee is now a consultant at Heron Health.
Kat photo Katrina Evetts (2000-2004): Kat was a technician funded by the MRC who worked on the Rho family project. She doesn't really look like this but we don't have her photo. Kat is currently working for Blood Products Ltd.