DNA and chromatin biology

Understanding how the genome is packaged, expressed, replicated and
repaired

Tom Blundell

Structural biology, bioinformatics and drug discovery

Transcriptional control of stem cell fate

Maintenance of genome stability

DNA repair and neurodegenerative diseases

Structural studies of chromatin assembly/disassembly

Macromolecular mechanisms of genome duplication and stability

The role of disordered proteins in nucleic acid condensation and scaffolding

Chromatin and gene regulatory proteins

Cell evolution – novel chromatin biology, remodelling of the cytoskeleton for parasitism, and organellogenesis in diverse eukaryotes