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Department of Biochemistry


Polyketides are natural products which provide a staggering range of clinically effective drugs. These include antibiotics (erythromycin A, monensin A, rifamycin S), immunosuppressants (rapamycin, FK506), antifungal (amphotericin B), antiparasitic (avermectin) and anticancer (doxorubicin) drugs. Not surprisingly polyketides generate great commercial interest and account for medicinal sales in excess of $10 billion per annum.