Selected, Recent Publications

FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells, Basu S, Needham L-M, Lando D, Taylor EJR, Wohlfahrt KJ, Shah D, Boucher W, Tan YL, Bates LE, Tkachenko O, Cramard J, Lagerholm BC, Eggeling C, Hendrich B, Klenerman D, Lee SF, Laue ED, Nature communications, 2018,  9, 2520, doi:10.1038/s41467-018-04486-0

Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell, Lando D, Basu S, Stevens TJ, Riddell A, Wohlfahrt KJ, Cao Y, Boucher W, Leeb M, Atkinson LP, Lee SF, Hendrich B, Klenerman D, Laue ED, Nature protocols, 2018, 13, 1034-1061, doi:10.1038/nprot.2018.017

3D structure of individual mammalian genomes studied by single cell Hi-C. Stevens TJ, Lando D, Basu S, Atkinson LP, Cao Y, Lee SF, Leeb M, Wohlfahrt KJ, Boucher W, O’Shaughnessy-Kirwan A, Cramard J, Faure AJ, Ralser M, Blanco E, Morey L, Sansó M, Palayret MGS, Lehner B, Di Croce L, Wutz A, Hendrich B, Klenerman D, Laue ED. Nature, 2017, 544(7648): 59-64

The Nucleosome Remodeling and Deacetylase Complex NuRD is built from preformed catalytically active sub-modules. Zhang W, Aubert A, Gomez de Segura JM, Karuppasamy M, Basu S, Murthy AS, Diamante A, Drury TA, Balmer J, Cramard J, Watson AA, Lando D, Lee SF, Palayret M, Kloet SL, Smits AH,  Deery MJ, Vermeulen M, Hendrich B, Klenerman D, Schaffitzel C, Berger I, Laue ED, Journal of Molecular Biology, 2016, 428(14): 2931-42.

Insight into the architecture of the NuRD complex: Structure of the RbAp48-MTA1 sub-complex. Alqarni SSM, Murthy A, Zhang W, Przewloka MR, Silva APG, Watson AA, Lejon S, Pei XY, Smits AH, Kloet SL, Wang H, Shepherd NE, Stokes PH, Blobel GA, Vermeulen M, Glover DM, Mackay JP, Laue ED, Journal of Biological Chemistry, 2014, 289(32):21844-21855

Single-cell Hi-C reveals cell-to-cell variability in chromosome structure. Nagano T, Lubling Y, Stevens TJ, Schoenfelder S, Yaffe E, Dean W, Laue ED, Tanay A, Fraser P, Nature, 2013, 502: 59-64

Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1. Zhang W, Tyl M, Ward R, Sobott F, Maman J, Murthy AS, Watson AA, Fedorov O, Bowman A, Owen-Hughes T, EL-Mkami H, Murzina NV, Norman D, Laue ED, Nat Struct Mol Biol, 2013, 20(1): 29-35

Quantitative single-molecule microscopy reveals that CENP-A(Cnp1) deposition occurs during G2 in fission yeast. Lando D, Endesfelder U, Berger H, Subramanian L, Dunne PD, McColl J, Klenerman D, Carr AM, Sauer M, Allshire RC, Heilemann M, Laue ED, Open Biol, 2012, 2 (7): 120078