Selected, Recent Publications

3D structure of individual mammalian genomes studied by single cell Hi-C. Stevens TJ, Lando D, Basu S, Atkinson LP, Cao Y, Lee SF, Leeb M, Wohlfahrt KJ, Boucher W, O’Shaughnessy-Kirwan A, Cramard J, Faure AJ, Ralser M, Blanco E, Morey L, Sansó M, Palayret MGS, Lehner B, Di Croce L, Wutz A, Hendrich B, Klenerman D, Laue ED. Nature, 2017, doi: 10.1038/nature21429

The Nucleosome Remodeling and Deacetylase Complex NuRD is built from preformed catalytically active sub-modules. Zhang W, Aubert A, Gomez de Segura JM, Karuppasamy M, Basu S, Murthy AS, Diamante A, Drury TA, Balmer J, Cramard J, Watson AA, Lando D, Lee SF, Palayret M, Kloet SL, Smits AH,  Deery MJ, Vermeulen M, Hendrich B, Klenerman D, Schaffitzel C, Berger I, Laue ED, Journal of Molecular Biology, 2016, 428(14): 2931-42.

The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, Artero J-B, Callow P, Przewloka MR, Watson AA, Zhang W, Glover DM, Debski J, Dadlez M, Round AR, Forsyth VT, Laue ED, Journal of Molecular Biology, 2015, 427:1949-63.

Insight into the architecture of the NuRD complex: Structure of the RbAp48-MTA1 sub-complex. Alqarni SSM, Murthy A, Zhang W, Przewloka MR, Silva APG, Watson AA, Lejon S, Pei XY, Smits AH, Kloet SL, Wang H, Shepherd NE, Stokes PH, Blobel GA, Vermeulen M, Glover DM, Mackay JP, Laue ED, Journal of Biological Chemistry, 2014, 289(32):21844-21855

Single-cell Hi-C reveals cell-to-cell variability in chromosome structure. Nagano T, Lubling Y, Stevens TJ, Schoenfelder S, Yaffe E, Dean W, Laue ED, Tanay A, Fraser P, Nature, 2013, 502: 59-64

Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1. Zhang W, Tyl M, Ward R, Sobott F, Maman J, Murthy AS, Watson AA, Fedorov O, Bowman A, Owen-Hughes T, EL-Mkami H, Murzina NV, Norman D, Laue ED, Nat Struct Mol Biol, 2013, 20(1): 29-35

Quantitative single-molecule microscopy reveals that CENP-A(Cnp1) deposition occurs during G2 in fission yeast. Lando D, Endesfelder U, Berger H, Subramanian L, Dunne PD, McColl J, Klenerman D, Carr AM, Sauer M, Allshire RC, Heilemann M, Laue ED, Open Biol, 2012, 2 (7): 120078

The PHD and Chromo Domains Regulate the ATPase Activity of the Human Chromatin Remodeler CHD4. Watson AA, Mahajan P, Mertens HD, Deery MJ, Zhang W, Pham P, Du X, Bartke T, Edlich C, Berridge G, Chen Y, Burgess-Brown NA, Kouzarides T, Wiechens N, Owen-Hughes T, Svergun DI, Gileadi O, Laue ED, J Mol Biol, 2012, 422 (1): 3-17

A software framework for analysing solid-state MAS NMR data. Stevens TJ, Fogh RH, Boucher W, Higman VA, Eisenmenger F, Bardiaux B, van Rossum BJ, Oschkinat H, Laue ED, J Biomol NMR, 2011, 51(4): 437-47