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Hollfelder group

Miriam Klaus

PhD student
Joined the lab: March 2018
Background and Current Projects: I studied Biochemistry at the Freie Universität Berlin and later joined the 'International Max Planck Research School  for Molecular Biology' in Göttingen where I graduated with a master's degree in 2017. I am generally interested in the structure-function correlation of enzymes – especially with regard to protein dynamics and molecular interactions - and in the translation of such knowledge into rational and straight-forward pharmacology and biotechnology.
During my bachelor's thesis in the laboratory of Dr. Ralf Jauch in Guangzhou, I designed inhibitors for the 'undruggable' transcription factor SOX18, using its sequence and structural features as reference points to install specificity. At the MPI for biophysical chemistry, I worked with crystal and NMR structures to understand signal transduction across membranes and to identify starting points for saturation mutagenesis in order to develop proteases with optimized efficiency and orthogonality.
To improve my mechanistic understanding of enzyme catalysis, I finally joined the group of Prof. Tittmann for my master's thesis. There, I focused on the metabolic enzyme transaldolase and on giving meaning to its different conformational states.
After graduating, I worked for Evotec's biophysics department until joining the Hollfelder lab in March 2018 on a Marie-Curie Scholarship. During my PhD, I would like to set particular focus on carbonyl reduction and the enantioselective production of chiral alcohols as well as its role in xenobiology.
Interests: I enjoy hiking, travelling, board games and books.

Publications

M. Klaus*, N. Prokoph*, M. Girbig, X. Wang, Y. Huang, Y. Srivastava, L. Hou, K. Narasimhan, P. Kolatkar, M. Francois, R. Jauch, “Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction”, Nucleic Acid Research, 2016, 44 (8): 3922-3935 (* - equal contribution). Read online

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