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Department of Biochemistry


Joachim De Jonghe

PhD student
Joined the lab: January 2016
Background and Current Projects: After receiving my BSc in Life Sciences at EPFL, I decided to move to London for a MSc in Biomedical Engineering at Imperial College. I completed my master thesis at the centre for Synthetic Biology under the supervision of Dr. Tom Ellis, where I evolved bacterial and Yeast promoters to improve transcription rates and create new DNA parts using mutagenic PCR.
As my career interests gravitated towards research, I decided to apply for a Msc in Molecular Medicine at EPFL to strengthen my background in molecular biology and engineering. I then crossed the Atlantic Ocean to complete my thesis at the Broad Institute under the supervision of Dr. Paul Blainey, to develop a microfluidic device for library preparation of clinical isolates for next-generation sequencing (NGS).
As a PhD student in the Hollfelder lab, I will continue to explore the interplay between microfluidics and next-generation sequencing, with a focus on single-cell transcriptomics.
Interests: I enjoy travelling (like everyone else in the Hollfelder lab), listening to music, playing some pool and some guitar.


[3] Kim S, De Jonghe J, Kulesa AB, Feldman D, Vatanen T, Bhattacharyya RP, Berdy B, Gomez J, Nolan J, Epstein S, Blainey PC. High-throughput automated microfluidic sample preparation for accurate microbial genomics. Nature Communications 2017, 8, 13919. read online

[2] Reeve B, Martinez-Klimova E, De Jonghe J, Leak DJ, Ellis T. The Geobacillus plasmid set: a modular toolkit for thermophile engineering. ACS synthetic biology 2016, 5(12), 1342-1347. read online

[1] Casini A, MacDonald JT, De Jonghe J, Christodoulou G, Freemont PS, Baldwin GS, Ellis T. One-pot DNA construction for synthetic biology: the Modular Overlap-Directed Assembly with Linkers (MODAL) strategy. Nucleic Acids Res. 2014, 42(1):e7. read online


Joachim De Jonghe

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