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The Department's buildings are currently open for wet laboratory work only. We have carried out a comprehensive COVID-19 risk assessment process and have introduced a number of new measures to ensure the safety of our staff, including reduced building occupancy, strict social distancing, 'family'-based working, and increased cleaning and hygiene regimes. All staff who can work remotely will do so for the foreseeable future. Please continue to contact us by email until further notice.

Department of Biochemistry

 

Michael Herger

PhD student
Joined the lab: January 2016
Background and Current Projects: After receiving my BSc in Interdisciplinary Sciences at ETH Zurich, I completed my MSc in October 2015 with a major in Biology and Chemistry. My master’s thesis in Prof. F. H. Arnold’s group at Caltech (Pasadena, USA) comprised the directed evolution of a tryptophan synthase beta-subunit for substrate promiscuity to allow for enzymatic synthesis of a broad range of non-canonical amino acids.
After a student internship at Roche, where I evaluated a novel affinity tag for mass-spectrometric analysis of cell surface proteins, I joined Florian Hollfelder’s group for my PhD studies. My project is in collaboration with MedImmune and aims at enhancing CRISPR-associated nucleases for genome editing by means of directed evolution.
Interests: I enjoy travelling and most outdoor sports (often in combination). Recent hobbies include cycling, bouldering, and kayaking.

Publications
[2] A. R. Buller, S. Brinkmann-Chen, D. K. Romney, M. Herger, J. Murciano-Calles, F. H. Arnold, Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation. PNAS 112, 14599-14604 (2015) read online
[1] K. Eyer, M. Herger, S. D. Krämer, P. S. Dittrich, Cell-Free Microfluidic determination of P-glycoprotein interactions with substrates and inhibitors. Pharmaceutical Research 31, 3415-3425 (2014) read online

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Michael Herger 

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