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Department of Biochemistry


Luca Pellegrinet

Luca joined Professor Evan’s research group in 2012 supported by a Swiss National Science Foundation as well as a Marie Curie European personal fellowships.

His research focuses on the relationship between cancers and physiological but not homeostatic processes like tissue regeneration and wound healing, with particular emphasis on epithelial-stroma-immune cell interactions. In a collaborative project Luca aims at better defining these processes at the genomic level by integrative analysis of transcriptional regulation and the 3D genome architecture.

Before joining University of Cambridge, Luca completed his PhD at the Swiss Institute for Experimental Cancer Research (ISREC/EPFL) in Lausanne, where he contributed to dissect the role of the Notch signalling pathway in controlling gut self-renew and as a gatekeeper for intestinal stem cells maintenance.

In addition, since 2013 Luca is lecturing and supervising Biochemistry and Zoology undergraduates in the Natural sciences curriculum at University of Cambridge. He is an Associate Fellow of the Higher Education Academy since 2015 as well as a Postdoctoral associate of Trinity Hall College, Cambridge.


  • Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors.
    Kress TR, Pellanda P, Pellegrinet L, Bianchi V, Nicoli P, Doni M, Recordati C, Bianchi S, Rotta L, Capra T, Ravà M, Verrecchia A, Radaelli E, Littlewood TD, Evan GI, Amati B.
    Cancer Res. 2016 Jun 15;76(12):3463-72.
  • Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch.
    López-Arribillaga E, Rodilla V, Pellegrinet L, Guiu J, Iglesias M, Roman AC, Gutarra S, González S, Muñoz-Cánoves P, Fernández-Salguero P, Radtke F, Bigas A, Espinosa L.
    Development. 2015 Jan 1;142(1):41-50.
  • Generation and characterization of a Notch1 signaling-specific reporter mouse line.
    Smith E, Claudinot S, Lehal R, Pellegrinet L, Barrandon Y, Radtke F.
    Genesis. 2012 Sep;50(9):700-10.
  • Dll1-and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells.
    Pellegrinet L, Rodilla V, Liu Z, Chen S, Koch U, Espinosa L, Kaestner KH, Kopan R, Lewis J, Radtke F.
    Gastroenterology. 2011 Apr;140(4):1230-1240.e1-7.
  • Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.
    Riccio O, van Gijn ME, Bezdek AC, Pellegrinet L, van Es JH, Zimber-Strobl U, Strobl LJ, Honjo T, Clevers H, Radtke F.
    EMBO Rep. 2008 Apr;9(4):377-83.

updated: May 2016