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Evan Group Alumni - Debbie Burkhart

Deborah Lynn Burkhart


Time in the Lab: September 2009 - August 2017

Background and Current Projects: I completed my university degrees in Biology and Literature at the Massachusetts Institute of Technology in 2003. At MIT, I performed a yeast-one hybrid screen to identify regulators of the Drosophila telomeric retrotransposons during two and half years in the Pardue lab. I then moved to the lab of Professor Julien Sage in the Cancer Biology Program at Stanford University, where I completed my Ph.D. in 2009. In the Sage lab my thesis focused on understanding the transcriptional networks encompassing the regulation of the RB-family of cell cycle regulators. In the Evan lab, I study a variety of models that aim to understand the relationship between oncogenic signals and induction of tumour suppression. In particular, current work focuses on the balance between Myc induced proliferation and apoptosis, the differences in regulation between mouse and human ARF proteins, and the potential therapeutic index of targeting wild-type Ras protein function in a variety of tumour models.

Interests:  In my free time I enjoy family life, reading, and taking my beagle on long walks. I also enjoy traveling around Britain and Europe.

Selected publications:

  • Burkhart DL, Wirt SE, Zmoos AF, Kareta M, Sage J. Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions, PLoS Genetics, 2010. 6(6).
  • Burkhart DL, Ngai LK, Roake CM, Viatour P, Thangavel C, Ho VM , Knudsen ES, and Sage J. Regulation of RB Transcription In Vivo by RB Family Members, Molecular and Cellular Biology, 2010. 30(7): p. 1729-1745.
  • Burkhart DL and Sage J. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nature Reviews Cancer, 2008. 8(9): p. 671-82.
  • Burkhart DL, Viatour P, Ho VM, Sage J. GFP reporter mice for the retinoblastoma-related cell cycle regulator p107. Cell Cycle, 2008. 7(16).