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Evan Group Alumni - Dan Lu

Dan Lu

Time in the lab: 2012-2016

Background: I was admitted into the University of Cambridge, St John’s College to study Natural Science in 2007 on the Cambridge Overseas Trust Scholarship presented by HRH, Prince Charles, graduating in 2011 with B.A. and M.Sci degrees. During my undergraduate studies, I took part in various short-term research projects in the labs of Dr. Viji Draviam (University of Cambridge), Prof. Austin Smith (University of Cambridge) and Prof. Jianzhu Chen (Massachussetts Institute of Technology), as well as being the President of the Cambridge University Biological Society. During my PhD, I have been a college lecturer at Downing College Cambridge, for which I was awarded a Bye-fellowship in recognition of my teaching in 2013.

Research Project: Cancer therapy relies on targeting vulnerabilities in tumour cells that are not present in normal physiological cells. Previous work in the lab has demonstrated the specific killing of tumour cells (but not normal proliferating cells) following inhibition of the transcription factor and oncoproteins, MYC, establishing a clear therapeutic window. My PhD project has focused on identifying the causal mechanisms of tumour cell death using 2D and 3D in vitro tumour cell models, focusing on perturbations of metabolic and apoptotic pathways.