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Vacancies in the Department

Accounts Clerk

From Jobs at the University of Cambridge. Published on Nov 08, 2017.

Applications are invited for the post of Accounts Clerk in the Department of Biochemistry.

The Department of Biochemistry is a member of the School of the Biological Sciences and one of the largest departments in the University of Cambridge.

The Accounts Clerk works as part of a team of three supervised by the Chief Accounts Clerk. The team is responsible for the financial activities of the department.

This is a varied and interesting role having responsibility for the processing of purchase and sales invoices, receipts, supplier payments, petty cash and other general activities expected within a busy departmental accounts office.

The ideal candidate will hold or be studying for a financial qualification, have a least 4 GCSE's at Grade C or equivalent (including English and Mathematics), be enthusiastic, adaptable and able to provide a friendly and efficient service at all times.

Applications must be received by 5pm on the closing date.

Informal enquiries can be made to Sandy Norton - sjn51@cam.ac.uk. Any enquiries relating to the application process please contact the Personnel Team personnel@bioc.cam.ac.uk.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PH13931 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

BBSRC PhD Studentship - Host-parasite interactions in African Trypanosomes

From Jobs at the University of Cambridge. Published on Nov 02, 2017.

BBSRC-Funded 4-Year Targeted PhD Studentship

Supervisor: Dr Paula MacGregor, Department of Biochemistry, University of Cambridge

Project title: Host-parasite interactions in African Trypanosomes

Project Description:

Several trypanosome species are pathogens of humans and livestock in sub-Saharan Africa. Successful infection and transmission relies on the ability of the trypanosome to detect, interact with, and adapt to its environment. As extracellular parasites, the trypanosome cell surface acts as the molecular interface between the parasite and its external environment and functions in nutrient acquisition, signalling, and countering host innate and adaptive immune attack. While the major surface protein, the Variant Surface Glycoprotein (VSG), has been well characterised, considerably less is known about the non-VSG proteins on the trypanosome cell surface. Further, the protein composition at the trypanosome cell surface varies between species.

This project will involve the characterisation of novel bloodstream-stage Trypanosoma congolense-specific surface proteins that are hypothesised to play a role in host-parasite interactions. This work will inform how different trypanosome species are able to interact with their range of mammalian hosts through non-VSG surface proteins and how those interactions evolved.

This project is suitable for a candidate with an Honours Bachelors Degree (Minimum Class 2.1), or equivalent, in a relevant biological subject. A Masters degree, or equivalent experience, would be advantageous. The candidate should have an interest in molecular parasitology.

Funding Notes:

This is a BBSRC DTP Programme 4-Year Targeted PhD studentship (Research Theme: Agriculture and Food Security). The student must complete the programme in 48 months, commencing in October 2018. They will be part of an interdisciplinary cohort of students participating in DTP training courses and events. In addition to the primary PhD research, the student will complete two 10-week rotation projects (one in the MacGregor group) and a three-month internship.

The studentship will cover a stipend at the standard Research Council rate (£14,553 per annum for 2017/18), research costs and tuition fees at the UK/EU rate, and is available for UK and EEA students who meet the UK residency requirements.

Application:

Candidates should initially apply directly to Dr Paula MacGregor - pm560@cam.ac.uk. Applications must include (i) A detailed CV, (ii) A cover letter, outlining motivation for the application and a description of any past research experience and future interests and (iii) the details of at least two references. Incomplete applications will not be considered. Selected candidates will be interviewed and the successful applicant will then be required to apply through the Department of Biochemistry Postgraduate Admissions Applicant Portal. Interviews will take place in December 2017.

Please quote reference PH13913 on your application and in any correspondence about this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Both the University and the Department of Biochemistry are committed to equality and diversity.

Cambridge/MedImmune PhD Studentship - Cell biology and the actin cytoskeleton

From Jobs at the University of Cambridge. Published on Oct 30, 2017.

An innovative, competitively funded PhD programme has been established between the University of Cambridge and MedImmune. Applications are invited for the October 2018 intake for a studentship hosted at the Gurdon Institute, MedImmune and Department of Biochemistry. This is a 3 year fully-funded studentship with an additional 4th year of stipend if required. The collaboration with MedImmune is a key feature of this project, giving the student insight into the drug discovery process in a commercial setting. The first year will involve a placement at MedImmune of at least 3 months with further work determined by the needs of the project.

Project details: Cell biology and the actin cytoskeleton

The actin cytoskeleton interfaces with many processes in cell biology, from cell shape and protrusions to membrane traffic. This means that where and when the assembly of actin filaments gives rise to a larger actin assembly that achieves a particular cell biological role is highly regulated by many different proteins. This project seeks to determine the proteins that are involved in making filopodia-like structures, which resemble filopodia, finger-like protrusions from cells. Filopodia-like structures can be made in a cell-free format using cytosolic extracts and artificial membranes (Science 329:1341, 2010). This cell-free system means that antibody technology can be used to target the proteins involved. The aims of the project are to characterise antibodies that affect the formation of filopodia-like structures, identify their target antigens and find out how they are used in filopodia formation in cells.

About the Gurdon Institute and Department of Biochemistry

This project is based in the Gallop Lab within the Gallop Lab is based in the Gurdon Institute which benefits from core funding from the Wellcome Trust and state-of-art laboratories in the centre of Cambridge. The student will be registered within the Department of Biochemistry which offers a highly supportive environment with Graduate Thesis Panels to advise on your project. Vibrant programs of seminars, retreats and events tailored to personal training and development are an integral part of work and study.

About Medimmune

MedImmune, the global biologics unit of AstraZeneca, is committed to developing better medicines that help people live healthier, longer and more satisfying lives. The company is focused on the areas of cardiovascular and metabolic disease, infection, respiratory diseases, and oncology, with two marketed products and a robust pipeline of promising new product candidates. MedImmune's state-of-the-art Cambridge site is home to around 600 employees, and serves as the company's European hub for research and development.

Further Information:

For this studentship we are looking for candidates with an actual or anticipated 1st or 2i Class degree in a relevant undergraduate subject (e.g. Biological Sciences, Biochemistry, or Cell Biology). Additional qualifications/experience (e.g. at MSc/MPhil level) in a cognate area would be an advantage but not essential. Further information on the MedImmune programme: https://gcat.medschl.cam.ac.uk/graduate-training-office/clinical-school-graduate-degree-courses/medimmunecambridge-phd-programme-in-biomedical-research/

Candidates are encouraged to contact the supervisors for any informal enquiries:

Dr Jenny Gallop (j.gallop@gurdon.cam.ac.uk) Department of Biochemistry, University of Cambridge.

Dr Claire Dobson (DobsonC@medimmune.com), MedImmune Ltd., Cambridge.

How to Apply:

Please note that this project is open to UK/EU applicants only. Applications should be made on-line via the Cambridge Graduate Admissions Office applicant portal www.graduate.study.cam.ac.uk/applicant-portal selecting course details MDMDMI22 MedImmune@Medicine.

The deadline for applications is 30th November 2017.

Interviews: late January 2018, date to be confirmed.

Please quote reference PH13825 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Nov 09, 2017.

Functional Characterisation of insect nicotinic Acetylcholine Receptors

Proteomics/Mass Spectrometry, Department of Biochemistry, University of Cambridge, Cambridge.

Fixed-term: The funds for this post are available for 36 months in the first instance.

This post represents an outstanding opportunity for a protein biochemist to join a multi-disciplinary team working as part of a BBSRC Industrial Partnership Award involving the Departments of Biochemistry and Genetics in Cambridge and Syngenta Jeallott's Hill International Research Centre in Berkshire. Despite their importance as major insecticide targets and critical regulators of insect neurophysiology, we know little about the roles that different subunits of nicotinic Acetylcholine Receptors play in their function. A better understanding these roles is key to more rational design of safe and effective next generation insecticides. We aim of elucidate the role of nicotinic Acetyl Choline Receptor (nAchRs) subunits within receptors and resulting heterogeneity of receptor complexes using a combination of genome editing, membrane proteomics, ligand binding assays and molecular modelling to facilitate rational design of more selective insecticides. The groups of Prof. Kathryn Lilley (Biochemistry) and Prof. Steve Russell (Genetics) are keen to employ a post-doctoral researcher to work to characterise the nAChRs from Drosophila using cutting edge membrane proteomics tools, building on tools developed by both groups (1,2) and at Syngenta, along with novel technology created by the Dafforn group at the University of Birmingham (3). We are seeking a candidate with experience in quantitative membrane proteomics, and mass spectrometry. Experience in computational proteomics, ligand binding assays and Drosophila biology is also desirable.

Refs: 1. Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Lowe N et al. Development. 2014 1(20):3994-4005. doi: 10.1242/dev.111054 2. Analysis of Drosophila melanogaster proteome dynamics during embryonic development by a combination of label-free proteomics approaches. Fabre B, et al Proteomics. 201614 (15-16):2068-80. doi: 10.1002/pmic.201500482 3. A method for detergent-free isolation of membrane proteins in their local lipid environment. Lee SC, et al, Nat Protoc. 2016 11(7):1149-62. doi: 10.1038/nprot.2016.070

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

If you have any questions about the application process, please contact Adriana Dote (personnel@bioc.cam.ac.uk).

Please quote reference PH13981 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate in Structural Biology

From Jobs at the University of Cambridge. Published on Oct 10, 2017.

Research Associate in Structural Biology: Structural basis of meiotic chromosome organization by the synaptonemal complex.

A postdoctoral position is available in the group of Prof. Luca Pellegrini in the Department of Biochemistry of the University of Cambridge, to work on the role of the synaptonemal complex in establishing the functional architecture of homologous chromosomes in meiosis, which is essential for correct chromosome pairing and genetic recombination (Syrjanen et al, eLife, 2017; Syrjanen et al, eLife, 2014). A multi-disciplinary approach involving biochemical and biophysical experiments will be used to elucidate the molecular mechanisms of synaptonemal complex assembly on the meiotic chromosome axis. The ultimate goal of the project is to achieve the biochemical reconstitution and structural analysis of meiotic chromosome organisation from purified protein components.

Successful candidates will hold or about to be awarded a PhD in Biochemistry, Biophysics or Molecular Biology and must be able to demonstrate a proven track record in conducting internationally-competitive research. Most of all, they must be exceptionally enthusiastic and motivated to succeed in fundamental research.

Applicants should submit a CV with list of relevant publications, a cover letter explaining why they are suitable for the position and contact information for at least two referees.

The position is available from January 1st, 2018 and is tenable for a period of one year initially.

Informal enquiries can be made to Luca Pellegrini at lp212@cam.ac.uk. https://www.bioc.cam.ac.uk/people/uto/pellegrini

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

If you have any questions about the application process, please contact Adriana Dote (personnel@bioc.cam.ac.uk).

Please quote reference PH13585 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Structural Bioinformatician (Fixed Term)

From Jobs at the University of Cambridge. Published on Nov 07, 2017.

Applications are invited for a postdoctoral computational biologist to join the Laboratory of Professor Sir Tom Blundell at the University of Cambridge, Department of Biochemistry, Central Cambridge.

The successful candidate will work on a project, funded by the Cystic Fibrosis Trust as a Strategic Research Centre in Cambridge, to understand the strain variation and development of antimicrobial resistance in Mycobacterium abscessus. This is a collaborative grant led by clinician Professor Andres Floto, and involving Professor Chris Abell,in Department of Chemistry, university of Cambridge, and Dr Julian Parkhill at the Wellcome Trust Genome Campus.

Mycobacterium Abscessus (Mab) is distantly related to tuberculosis, and can cause a devastating lung infection in CF individuals. This can be impossible to treat, often prevents safe transplantation, and leads to accelerated lung damage and death. The project will involve analysis of a sequenced global collection of over 1500 clinical isolates and a mutant library of Mab. The post-holder will make a computational protein-structure analysis of Mab proteome to identify critical genes responsible for survival and infection - these genes will then become targets for our Fragment-based Drug Discovery campaign.

The Blundell group has already begun to generate an Mab proteome database using modeling programs developed over the past 30 years, including Fugue, Modeller, and other software pipelines developed for the Mycobacterium tuberculosis database, CHOPIN. The post-holder will generate models built on structures of homologues, with multiple models for conformational states characteristic of different oligomeric states and ligand binding, including identification of hotspots and binding cavities, reflecting various functional states of the proteins. Knowledge of the computational proteome will provide crucial support for conventional and target-agnostic fragment-based drug discovery campaigns, and allow in silico chemical screening and cheminformatic predictions. The pipeline will also provide structural analyses of mutations, associated with strain variation and drug resistance, using our software SDM and mCSM. Detailed drug resistance/tolerance phenotyping of clinical isolates that have already been whole-genome sequenced will allow experimental validation of these predictions and provide a large training set for machine learning computational approaches. This will then provide the basis for analysis of new clinical isolates and the mutant library of Mab.

The successful candidate must have or be about to complete a PhD, preferably in a computationally focused research project. Knowledge of developing software in genomics and/or structural proteomics is required, with skills in coding in Python desirable.

Fixed-term: The funds for this post are available for 24 months in the first instance.

If you have any questions about this vacancy, please contact Prof Sir Tom Blundell (tom@cryst.bioc.cam.ac.uk).

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

If you have any questions about the application process, please contact Adriana Dote (personnel@bioc.cam.ac.uk).

Please quote reference PH13944 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Structural Bioinformatician (Part Time, Fixed Term)

From Jobs at the University of Cambridge. Published on Nov 07, 2017.

Applications are invited for a postdoctoral computational biologist to join the Laboratory of Professor Sir Tom Blundell at the University of Cambridge, Department of Biochemistry, Central Cambridge.

The successful candidate will work on a project, funded by the UK MRC Newton Fund in collaboration with the Department of Biotechnology (DBT) India, to understand the strain variation and development of antimicrobial resistance in Mycobacterium tuberculosis in Southern India. This is a collaborative grant led by Dr Sharon Peacock, a clinical microbiologist (originally at the Department of Medicine in Cambridge) and involving clinician Professor Andres Floto, and Dr Julian Parkhill at the Wellcome Trust Genome Campus. The Indian collaborators are based at the National Institute for Research in Tuberculosis (NIRT) in Chennai. The objective is to understand the impact of polymorphisms in strains of Mycobacterium tuberculosis on structure, function and drug binding to targets of existing Mycobacterium tuberculosis drugs and therefore to understand antimicrobial resistance. The post holder will align new sequences of strains of Mycobacterium tuberculosis to Chopin, our database of the M. tuberculosis structural proteome. This will be used to analyse the impacts of polymorphisms on using both machine learning and statistical analyses of effects on protein stability (mCSM & SDM), protein-protein (mCSM-PPI & mCSM NA) and protein-nucleic acid interactions, and protein-ligand interactions (mCSM-lig) with a view to understanding and predicting drug resistance. The post holder will also analyse the "druggability" of M. tuberculosis protein structures to identify new targets.

The successful candidate must have or be about to complete a PhD, preferably in a computationally focused research project. Experience in developing software in genomics or structural proteomics is required.

This appointment is part time (3 days/week). Salary £31,604-£38,833 will be pro-rated.

Fixed-term: The funds for this post are available for 12 months in the first instance.

If you have any questions about this vacancy, please contact Prof Sir Tom Blundell (tom@cryst.bioc.cam.ac.uk).

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

If you have any questions about the application process, please contact Adriana Dote (personnel@bioc.cam.ac.uk).

Please quote reference PH13941 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Structural Biologist (Fixed Term)

From Jobs at the University of Cambridge. Published on Nov 20, 2017.

Applications are invited for a postdoctoral structural biologist to join the Laboratory of Professor Sir Tom Blundell at the University of Cambridge, Department of Biochemistry, Central Cambridge. The successful candidate will work on a project, funded by the Cystic Fibrosis Trust as a First UK CF Innovation Hub based in Cambridge, to develop new candidate drugs and understand the development of antimicrobial resistance in Mycobacterium abscessus and Pseudomonas aeruginosa. This is a collaborative grant led by clinician Professor Andres Floto of the Clinical School, and involving Professor Chris Abell in Department of Chemistry, university of Cambridge, and Dr Julian Parkhill at the Wellcome Trust Genome Campus.

Mycobacterium abscessus and Pseudomonas aeruginosa can cause devastating lung infections in cystic fibrosis individuals. This can be impossible to treat, often prevents safe transplantation, and leads to accelerated lung damage and death. The successful applicant will be involved in a project of structure-guided fragment-based drug discovery programme, collaboratively with the labs of Professor Abell in Chemistry and Professor Floto in the Clinical School Cambridge.

The post-holder will participate in the identification of targets using modern computational protein-structure and systems analysis of Pseudomonas aeruginosa to identify critical genes responsible for survival and infection - these genes will then become targets for our fragment-based drug discovery campaigns, in which the successful applicant will participate.

The Blundell group uses structure-guided fragment-based technologies already demonstrated in Astex Pharmaceuticals, a company co-founded by Tom Blundell, to be able develop candidate drugs in clinical trials in oncology and to get FDA approval for breast cancer. The Blundell group has also worked using these techniques in academia against mycobacterial targets including tuberculosis, abscessus and leprae. The post-holder will use molecular biology, biochemistry, biophysics techniques including surface plasmon resonance, ligand-based NMR, isothermal calorimetry, and X-ray analysis, as well as computational analysis of druggability to carry forward similar programmes against targets in Pseudomonas aeruginosa.

The successful candidate must have or be about to complete a PhD in structural biology with skills in preparative biochemistry, molecular biology, biophysical techniques and X-ray analysis. Knowledge of software in structural bioinformatics as well as experience of design of specific inhibitors of bacterial systems are desirable.

Fixed-term: The funds for this post are available for 24 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

If you have any questions about the application process, please contact Adriana Dote (personnel@bioc.cam.ac.uk).

Please quote reference PH14067 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Teaching Office Assistant

From Jobs at the University of Cambridge. Published on Nov 08, 2017.

Applications are invited for the post of Teaching Office Assistant in the Department of Biochemistry.

The Department of Biochemistry is a member of the School of the Biological Sciences and one of the largest departments in the University of Cambridge.

The Teaching Office Assistant assists the Teaching, Examinations and Postgraduate Administrator in the provision of confidential administrative and secretarial services to the Assistant Director of Teaching, Course Organisers and Senior Examiners, within the Department of Biochemistry.

We are seeking someone with a flexible and approachable manner and the ability to work either independently or as part of a team reflects the diverse nature of the responsibilities of this role. Applicants should have a good general education and a working knowledge of Microsoft Office applications including Word and Excel, as well as good secretarial, organisational and minute taking skills. Training will be given on other software packages in use within this busy teaching office, as necessary. The ideal applicant will be able to deal with a wide range of people, including academic staff and students.

The Department has an international reputation and attracts students and visitors from all over the world. The nature and scope of the role requires the post holder to deal with highly confidential material and with a wide range of people, both within the Department and externally.

Applications must be received by 5pm on the closing date.

Informal enquiries can be made to Christine Thulborn (ctt22@cam.ac.uk).

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PH13955 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.