Introduction

Research Groups

Select Research Group Head Prof. Sir Tom Blundell Prof. Kevin Brindle Dr Bill Broadhurst Dr Guy Brown Dr Mark Carrington Prof. Paul Dupree Prof. Gerard Evan - Head of Dept Prof. Richard Farndale Dr Giorgio Favrin Dr Jenny Gallop Dr Nick Gay Dr Andrew Grace Dr Jules Griffin Dr Brian Hendrich Dr Andrew Hesketh Dr Robin Hesketh Dr Matt Higgins Dr Florian Hollfelder Dr Hee-Jeon Hong Prof. Chris Howe Dr Marko Hyvonen Prof. Steve Jackson Dr Tony Jackson Prof. Richard Jackson Prof. Ernest Laue Prof. Peter Leadlay Dr Kathryn Lilley Dr Karen Lipkow Dr Rick Livesey Prof. Ben Luisi Dr Sarah Lummis Dr Juan Mata Dr John McCafferty Prof. Jim Metcalfe Dr Masanori Mishima Dr Eric Miska Dr Tom Monie Dr Helen Mott Dr Natasha Murzina Dr Daniel Nietlispach Dr Darerca Owen Prof. Steve Oliver Dr Luca Pellegrini Dr Markus Ralser Dr Nick Robinson Prof. George Salmond Dr Deirdre Scadden Dr José Silva Prof. Austin Smith Prof. Chris Smith Dr Nancy Standart Prof. Dame Jean Thomas Dr Aviva Tolkovsky Dr Martin Welch Dr Joyce Wong Dr Nianshu Zhang

Service & Research Support Facilities

Select by Subject or Manager DNA Sequencing Facility . . . . . Mr John Lester _______________________________ Quantitative Proteomics . . . . . Dr Kathryn Lilley _______________________________ Proteomics Core Services . . . . . Dr Mike Deery _______________________________ Protein & Nucleic Acid Chemistry . . . . . Dr Len Packman _______________________________ Metabolomics . . . . . Dr Jules Griffin _______________________________ Baculovirus Facility . . . . . Dr Darerca Owen _______________________________ Biophysics Facility . . . . . Dr Katherine Stott _______________________________ Crystallographic X-ray Facility . . . . . Dr Dima Chirgadze _______________________________ NMR spectroscopy . . . . . Dr Daniel Nietlispach _______________________________ Fermentation Facility . . . . . Dr Nianshu Zhang _______________________________ Bioinformatics & Computational Biology Services . . . . . Dr Jenny Barna _______________________________ Computer & IT Support . . . . . Dr Erik Timmers _______________________________

Past members last known active weblink

Select past member of Department Dr Stephen Bell Prof. Jonathan Blackburn Dr David Brown Dr Pak-Lee Chau Dr Hal Dixon (deceased) Dr Jessica Downs Prof. David Ellar Dr Paul Kemp Dr Simon Lovell Dr Kenji Mizuguchi Dr Massimo Paoli Prof. Richard Perham Dr Peter Reynolds Dr Philip Rubery Dr Gerry Smith Dr Margaret Sunde Prof. Jamie Vandenberg Dr Kira Weissman

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See also Cambridge Systems Biology Centre

Coupling Fermentation Technology with Systems Biology

Research Grouping: Functional genomics, systems biology and genetic medicine

The Fermentation Facility is a lab offering specialist services for Systems Biology studies, which focus on complex interactions in biological systems and often require quantitative and reproducible data at the levels of genome, transcriptome, proteome and metabolome, to model how a system works (see Prof. Steve Oliver’s web page and reference 1). Additionally, the facility offers research support to different departments of the University for biochemical/structural studies, where scaling-up of protein expression is required in different expression systems, including in mammalian cells (Fig.1).

Fig.1 In an analytical fermentation system, all the growth parameters, such as temperature, pH, dissolved oxygen level, growth rate or total biomass can be controlled reproducibly.		Fig.2 The proposed model for Gis1-dependent transcription upon nutrient starvation or rapamycin treatment. EF--epigenetic factors; ?--missing links.

The independent research of the lab focuses on how the transition of yeast cells into stationary phase is regulated. Previously, we have identified a number of yeast genes whose expression is significantly up-regulated following starvation for different macronutrients (2). Expression of some of these genes is strongly dependent on the Gis1 transcriptional factor and also on Rim15 and Sch9 kinases. The aim of the research is to understand how Tor and PKA signalling pathways regulate the activity of the Gis1 transcription factor through their downstream kinases and other epigenetic factors (Fig.2).

Lab members
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References