Introduction

Research Groups

Select Research Group Head Prof. Sir Tom Blundell Prof. Kevin Brindle Dr Bill Broadhurst Dr Guy Brown Dr Mark Carrington Prof. Paul Dupree Prof. Gerard Evan - Head of Dept Prof. Richard Farndale Dr Giorgio Favrin Dr Jenny Gallop Dr Nick Gay Dr Andrew Grace Dr Jules Griffin Dr Brian Hendrich Dr Andrew Hesketh Dr Robin Hesketh Dr Matt Higgins Dr Florian Hollfelder Dr Hee-Jeon Hong Prof. Chris Howe Dr Marko Hyvonen Prof. Steve Jackson Dr Tony Jackson Prof. Richard Jackson Prof. Ernest Laue Prof. Peter Leadlay Dr Kathryn Lilley Dr Karen Lipkow Dr Rick Livesey Prof. Ben Luisi Dr Sarah Lummis Dr Juan Mata Dr John McCafferty Prof. Jim Metcalfe Dr Masanori Mishima Dr Eric Miska Dr Tom Monie Dr Helen Mott Dr Natasha Murzina Dr Daniel Nietlispach Dr Darerca Owen Prof. Steve Oliver Dr Luca Pellegrini Dr Markus Ralser Dr Nick Robinson Prof. George Salmond Dr Deirdre Scadden Dr José Silva Prof. Austin Smith Prof. Chris Smith Dr Nancy Standart Prof. Dame Jean Thomas Dr Aviva Tolkovsky Dr Martin Welch Dr Joyce Wong Dr Nianshu Zhang

Service & Research Support Facilities

Select by Subject or Manager DNA Sequencing Facility . . . . . Mr John Lester _______________________________ Quantitative Proteomics . . . . . Dr Kathryn Lilley _______________________________ Proteomics Core Services . . . . . Dr Mike Deery _______________________________ Protein & Nucleic Acid Chemistry . . . . . Dr Len Packman _______________________________ Metabolomics . . . . . Dr Jules Griffin _______________________________ Baculovirus Facility . . . . . Dr Darerca Owen _______________________________ Biophysics Facility . . . . . Dr Katherine Stott _______________________________ Crystallographic X-ray Facility . . . . . Dr Dima Chirgadze _______________________________ NMR spectroscopy . . . . . Dr Daniel Nietlispach _______________________________ Fermentation Facility . . . . . Dr Nianshu Zhang _______________________________ Bioinformatics & Computational Biology Services . . . . . Dr Jenny Barna _______________________________ Computer & IT Support . . . . . Dr Erik Timmers _______________________________

Past members last known active weblink

Select past member of Department Dr Stephen Bell Prof. Jonathan Blackburn Dr David Brown Dr Pak-Lee Chau Dr Hal Dixon (deceased) Dr Jessica Downs Prof. David Ellar Dr Paul Kemp Dr Simon Lovell Dr Kenji Mizuguchi Dr Massimo Paoli Prof. Richard Perham Dr Peter Reynolds Dr Philip Rubery Dr Gerry Smith Dr Margaret Sunde Prof. Jamie Vandenberg Dr Kira Weissman

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DNA Sequencing Facility

The DNA Sequencing Facility in the department was started in 1993, with BBSRC funds, under the direction of Dr (now Professor) Peter Leadlay and subsequently equipped largely by grants held by Professor Leadlay. Since that time the Facility has developed rapidly as the ability to sequence genes has become a pervasive and essential tool in all areas of biological research. The scale of the projects tackled now ranges from the validation of single mutations in individual genes up to sequencing of entire microbial genomes. We have continually updated the equipment, in order to maximize the information obtained and to minimize turn-around time, and to make the Facility as user friendly as possible. The use of radioactive isotopes has been completely eliminated and all sequencing reactions are done by Facility staff, from the templates supplied.

Currently, sequencing is carried out on an Applied Biosystems 3730xl DNA Analyser, purchased with a BBSRC Research Equipment Award and funds generated by the Facility. This superb instrument utilizes a 96 capillary array and 96 reactions may be run in under two and a half hours, each reaction potentially giving up to 800 or more nucleotides of sequence from high quality templates. Results are usually sent by email to customers.

Facility staff have expertise in most aspects of DNA sequence analysis and can offer help and advice to both experienced researchers and to beginners. We welcome proposals for large-scale projects as well as for more routine small-scale sequencing.

Lab members
Naomi Bossley, Reda Deglau, Shilo Dickens, Anna Efimova, Markiyan Samborskyy, Nataliya Scott, Carolina Velez