Introduction

Research Groups

Select Research Group Head Prof. Sir Tom Blundell Prof. Kevin Brindle Dr Bill Broadhurst Dr Guy Brown Dr Mark Carrington Prof. Paul Dupree Prof. Gerard Evan - Head of Dept Prof. Richard Farndale Dr Giorgio Favrin Dr Jenny Gallop Dr Nick Gay Dr Andrew Grace Dr Jules Griffin Dr Brian Hendrich Dr Andrew Hesketh Dr Robin Hesketh Dr Matt Higgins Dr Florian Hollfelder Dr Hee-Jeon Hong Prof. Chris Howe Dr Marko Hyvonen Prof. Steve Jackson Dr Tony Jackson Prof. Richard Jackson Prof. Ernest Laue Prof. Peter Leadlay Dr Kathryn Lilley Dr Karen Lipkow Dr Rick Livesey Prof. Ben Luisi Dr Sarah Lummis Dr Juan Mata Dr John McCafferty Prof. Jim Metcalfe Dr Masanori Mishima Dr Eric Miska Dr Tom Monie Dr Helen Mott Dr Natasha Murzina Dr Daniel Nietlispach Dr Darerca Owen Prof. Steve Oliver Dr Luca Pellegrini Dr Markus Ralser Dr Nick Robinson Prof. George Salmond Dr Deirdre Scadden Dr José Silva Prof. Austin Smith Prof. Chris Smith Dr Nancy Standart Prof. Dame Jean Thomas Dr Aviva Tolkovsky Dr Martin Welch Dr Joyce Wong Dr Nianshu Zhang

Service & Research Support Facilities

Select by Subject or Manager DNA Sequencing Facility . . . . . Mr John Lester _______________________________ Quantitative Proteomics . . . . . Dr Kathryn Lilley _______________________________ Proteomics Core Services . . . . . Dr Mike Deery _______________________________ Protein & Nucleic Acid Chemistry . . . . . Dr Len Packman _______________________________ Metabolomics . . . . . Dr Jules Griffin _______________________________ Baculovirus Facility . . . . . Dr Darerca Owen _______________________________ Biophysics Facility . . . . . Dr Katherine Stott _______________________________ Crystallographic X-ray Facility . . . . . Dr Dima Chirgadze _______________________________ NMR spectroscopy . . . . . Dr Daniel Nietlispach _______________________________ Fermentation Facility . . . . . Dr Nianshu Zhang _______________________________ Bioinformatics & Computational Biology Services . . . . . Dr Jenny Barna _______________________________ Computer & IT Support . . . . . Dr Erik Timmers _______________________________

Past members last known active weblink

Select past member of Department Dr Stephen Bell Prof. Jonathan Blackburn Dr David Brown Dr Pak-Lee Chau Dr Hal Dixon (deceased) Dr Jessica Downs Prof. David Ellar Dr Paul Kemp Dr Simon Lovell Dr Kenji Mizuguchi Dr Massimo Paoli Prof. Richard Perham Dr Peter Reynolds Dr Philip Rubery Dr Gerry Smith Dr Margaret Sunde Prof. Jamie Vandenberg Dr Kira Weissman

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Structural Biology

Research Grouping: Structural and molecular cell biology

Our interests lie in the study of the structure and function of protein complexes. We mainly use either NMR spectroscopy or X-ray crystallography, but we also employ a wide range of biochemical methods to study cellular complexes both in vitro and in vivo. We are studying proteins which control signal transduction pathways, e.g. GPCRs and cyclin-dependent kinases, but we are primarily interested in the control of gene expression via chromatin structure. At the same time we are developing new NMR methods, in particular computational methods, to extend the scope of NMR spectroscopy for the study of the structure of larger macromolecules and their interactions. Two examples of recent work, the structures of the HP1 chromo domain/Lys-9 methylated Histone H3 and HP1 shadow domain/CAF-1 complexes are shown below.

We are increasingly directing our research towards structural studies that might be usefully employed in developing new therapies for cancer. We are particularly interested in fundamental studies of protein-protein interactions, and in providing greater understanding and knowledge of how such interactions might be interfered with for therapeutic benefit

Lab members
Jenny  Balmer, Wayne  Boucher, Yun (Krystal)  Chen, Alan Da Silva, Christian  Edlich, Rasmus  Fogh, Ian Le Guillou, John Ionides, Darima  Lamazhapova, David Lando, Sara Lejon, Buyu  Li, Andal Murthy, Daniel  O'Donovan, Nikki  Royle, Timothy  Stevens, Marek Tyl, Wim  Vranken, Aleksandra Watson, Wei  Zhang

Secretarial:

References