Introduction

Research Groups

Select Research Group Head Prof. Sir Tom Blundell Prof. Kevin Brindle Dr Bill Broadhurst Dr Guy Brown Dr Mark Carrington Prof. Paul Dupree Prof. Gerard Evan - Head of Dept Prof. Richard Farndale Dr Giorgio Favrin Dr Jenny Gallop Dr Nick Gay Dr Andrew Grace Dr Jules Griffin Dr Brian Hendrich Dr Andrew Hesketh Dr Robin Hesketh Dr Matt Higgins Dr Florian Hollfelder Dr Hee-Jeon Hong Prof. Chris Howe Dr Marko Hyvonen Prof. Steve Jackson Dr Tony Jackson Prof. Richard Jackson Prof. Ernest Laue Prof. Peter Leadlay Dr Kathryn Lilley Dr Karen Lipkow Dr Rick Livesey Prof. Ben Luisi Dr Sarah Lummis Dr Juan Mata Dr John McCafferty Prof. Jim Metcalfe Dr Masanori Mishima Dr Eric Miska Dr Tom Monie Dr Helen Mott Dr Natasha Murzina Dr Daniel Nietlispach Dr Darerca Owen Prof. Steve Oliver Dr Luca Pellegrini Dr Markus Ralser Dr Nick Robinson Prof. George Salmond Dr Deirdre Scadden Dr José Silva Prof. Austin Smith Prof. Chris Smith Dr Nancy Standart Prof. Dame Jean Thomas Dr Aviva Tolkovsky Dr Martin Welch Dr Joyce Wong Dr Nianshu Zhang

Service & Research Support Facilities

Select by Subject or Manager DNA Sequencing Facility . . . . . Mr John Lester _______________________________ Quantitative Proteomics . . . . . Dr Kathryn Lilley _______________________________ Proteomics Core Services . . . . . Dr Mike Deery _______________________________ Protein & Nucleic Acid Chemistry . . . . . Dr Len Packman _______________________________ Metabolomics . . . . . Dr Jules Griffin _______________________________ Baculovirus Facility . . . . . Dr Darerca Owen _______________________________ Biophysics Facility . . . . . Dr Katherine Stott _______________________________ Crystallographic X-ray Facility . . . . . Dr Dima Chirgadze _______________________________ NMR spectroscopy . . . . . Dr Daniel Nietlispach _______________________________ Fermentation Facility . . . . . Dr Nianshu Zhang _______________________________ Bioinformatics & Computational Biology Services . . . . . Dr Jenny Barna _______________________________ Computer & IT Support . . . . . Dr Erik Timmers _______________________________

Past members last known active weblink

Select past member of Department Dr Stephen Bell Prof. Jonathan Blackburn Dr David Brown Dr Pak-Lee Chau Dr Hal Dixon (deceased) Dr Jessica Downs Prof. David Ellar Dr Paul Kemp Dr Simon Lovell Dr Kenji Mizuguchi Dr Massimo Paoli Prof. Richard Perham Dr Peter Reynolds Dr Philip Rubery Dr Gerry Smith Dr Margaret Sunde Prof. Jamie Vandenberg Dr Kira Weissman

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Introduction

The research in the Department focuses on understanding the fundamental processes of biological systems, microbial, plant and animal. It includes work that is designed to advance biophysical, biocomputational, cellular and tissue methodologies. It contributes to and is closely integrated with research elsewhere in the School of Biological Sciences on the Downing and Old Addenbrooke’s sites.

Research programmes are led by over 40 principal investigators including the University staff and independent research fellows funded by the Royal Society, research councils and charities. The principal investigators are responsible for funding their own research programmes, through project and programme grants. They form collaborative groups focused on the research themes identified above. The research facilities are modern and extensive, with many new improvements and additions over the past ten years.

We have collaborated with the Department of Genetics in establishing the Systems Biology Centre, adjacent to the Sanger Building, which houses DNA micro-array technologies, proteomics and informatics, and we have established metabolomics elsewhere in the Department exploiting both NMR and mass spectrometry. We have established a new Chair of Systems Biology and Biochemistry.

The Department is a centre for structural biology, housing modern crystallisation and X-ray laboratories, funded by the Wellcome Trust and the BBSRC. The Department is a centre for macromolecular NMR with two 500 MHz, one 600 MHz and one 800 MHz NMR spectrometers. It houses mass spectrometers (notably electrospray, Q-TOF, MALDITOF and FTICR), a stopped-flow CD spectropolarimeter, automated DNA sequencing, surface plasmon resonance biosensor (BIAcore) and powerful computing and graphics facilities.

The Protein and Nucleic Acid Chemistry Facility provides a service for the synthesis of peptides, amino acid analysis and protein sequence analysis, and mass spectrometry. This unit complements the work of the well-equipped Cambridge Centre for Proteomics in the adjacent Systems Biology Centre, several of whose staff are members of Biochemistry.