Introduction

Research Groups

Select Research Group Head Prof. Sir Tom Blundell Prof. Kevin Brindle Dr Bill Broadhurst Dr Guy Brown Dr Mark Carrington Prof. Paul Dupree Prof. Gerard Evan - Head of Dept Prof. Richard Farndale Dr Giorgio Favrin Dr Jenny Gallop Dr Nick Gay Dr Andrew Grace Dr Jules Griffin Dr Brian Hendrich Dr Andrew Hesketh Dr Robin Hesketh Dr Matt Higgins Dr Florian Hollfelder Dr Hee-Jeon Hong Prof. Chris Howe Dr Marko Hyvonen Prof. Steve Jackson Dr Tony Jackson Prof. Richard Jackson Prof. Ernest Laue Prof. Peter Leadlay Dr Kathryn Lilley Dr Karen Lipkow Dr Rick Livesey Prof. Ben Luisi Dr Sarah Lummis Dr Juan Mata Dr John McCafferty Prof. Jim Metcalfe Dr Masanori Mishima Dr Eric Miska Dr Tom Monie Dr Helen Mott Dr Natasha Murzina Dr Daniel Nietlispach Dr Darerca Owen Prof. Steve Oliver Dr Luca Pellegrini Dr Markus Ralser Dr Nick Robinson Prof. George Salmond Dr Deirdre Scadden Dr José Silva Prof. Austin Smith Prof. Chris Smith Dr Nancy Standart Prof. Dame Jean Thomas Dr Aviva Tolkovsky Dr Martin Welch Dr Joyce Wong Dr Nianshu Zhang

Service & Research Support Facilities

Select by Subject or Manager DNA Sequencing Facility . . . . . Mr John Lester _______________________________ Quantitative Proteomics . . . . . Dr Kathryn Lilley _______________________________ Proteomics Core Services . . . . . Dr Mike Deery _______________________________ Protein & Nucleic Acid Chemistry . . . . . Dr Len Packman _______________________________ Metabolomics . . . . . Dr Jules Griffin _______________________________ Baculovirus Facility . . . . . Dr Darerca Owen _______________________________ Biophysics Facility . . . . . Dr Katherine Stott _______________________________ Crystallographic X-ray Facility . . . . . Dr Dima Chirgadze _______________________________ NMR spectroscopy . . . . . Dr Daniel Nietlispach _______________________________ Fermentation Facility . . . . . Dr Nianshu Zhang _______________________________ Bioinformatics & Computational Biology Services . . . . . Dr Jenny Barna _______________________________ Computer & IT Support . . . . . Dr Erik Timmers _______________________________

Past members last known active weblink

Select past member of Department Dr Stephen Bell Prof. Jonathan Blackburn Dr David Brown Dr Pak-Lee Chau Dr Hal Dixon (deceased) Dr Jessica Downs Prof. David Ellar Dr Paul Kemp Dr Simon Lovell Dr Kenji Mizuguchi Dr Massimo Paoli Prof. Richard Perham Dr Peter Reynolds Dr Philip Rubery Dr Gerry Smith Dr Margaret Sunde Prof. Jamie Vandenberg Dr Kira Weissman

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Structural Biology of Cellular Signalling by Toll/Interleukin 1 Transmembrane Receptors

Research Groupings: Structural and molecular cell biology | Developmental and regenerative biology and medicine

We are studying the structure and function of the human Toll-like receptor family and their signalling pathways. These molecules are required for initial responses to invading bacterial pathogens and are implicated in the generation of human disease states such as rheumatoid arthritis and septic shock. Our aim is to elucidate the detailed molecular structure of these receptors and the other components of the signalling pathway by X-ray crystallography, modelling and NMR methods. This information will provide a basis for the development of novel therapeutic agents effective in inflammatory diseases like rheumatoid arthritis.

The work is supported by grants from the European Union Fifth Framework programme ('Human Toll like receptors in chronic and degenerative disease'), the BBSRC Macromolecular assemblies initiative (Steroechemical mechanisms of signalling and translocation across membranes'), and the MRS ('Structural studies of human Toll/interleukin 1 receptor ectodomains and their ligands').

Lab members
Farhana Ahmadi, Alkisti Alveropoulou-Malli, J Arnold, Christopher Arnot, Jukka Aurikko, J-H Choo, Anthony Dossang, Monique Gangloff, Miranda Lewis, Ardi Liaunardy-Jopeace, Kristen E Mengwasser, Martin Moncrieffe, Ben Murton, Gugu Motshwene, Zhanna Oliferova, Olaniyi Opaleye, Brett Verstak, Joyce Wong

References