NST IB 2010-2011

Protein Structure by Molecular Graphics

Index

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Section 1: The polypeptide chain

Section 2(a): Secondary structure: The a-helix
Section 2(b): Secondary structure: The antiparallel b-sheet
Section 2(c): Secondary structure: The parallel b-sheet
Section 2(d): Secondary structure: b-sheet layers

Section 3(a): Super-secondary structures: The b-hairpin
Section 3(b): Super-secondary structures: The coiled-coil
Section 3(c): Super-secondary structures: The b-meander
Section 3(d): Super-secondary structures: The beta-alpha-beta motif
Section 3(e): Super-secondary structures: The Greek key motif
Section 3(f): Super-secondary structures: The double Greek key

Section 4(a): Functional motifs: The zinc finger
Section 4(b): Functional motifs: The helix-turn-helix motif
Section 4(c): Functional motifs: The Rossmann fold

Section 5(a): Tertiary structures: The four-helix bundle
Section 5(b): Tertiary structures: The TIM barrel
Section 5(c): Tertiary structures: The b-sandwich
Section 5(d): Tertiary structures: Immunoglobulin G

Section 6(a): Serine proteases: Chymotrypsinogen
Section 6(b): Serine proteases: Cysteine bridges
Section 6(c): Serine proteases: Chymotrypsin
Section 6(d): Serine proteases: Conformational changes on cleavage
Section 6(e): Serine proteases: Active site residues
Section 6(f): Serine proteases: The specificity pocket
Section 6(g): Serine proteases: A complex with an inhibitor

Section 7(a): Interesting structures: Circular proteins
Section 7(b): Interesting structures: Viral proteins
Section 7(c): Interesting structures: Membrane proteins

Appendix A: Mouse controls
Appendix B: Amino acid atlas
Appendix C: Hardware and software requirements
Appendix D: Links
Appendix E: Practical handout

If you need help with this practical, please contact

r.w.broadhurst@bioc.cam.ac.uk
Last updated 21/10/10