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Insight into DNA repair

last modified Nov 26, 2014 09:58 AM

Nick Robinson's and Luca Pellegrini's groups  have published a paper in Nature Communications entitled "Structure of the hexameric HerA ATPase reveals a mechanism of translocation-coupled DNA-end processing in archaea". Thermophilic archaea have a minimal double-strand DNA break repair apparatus consisting of the HerA ATPase, NurA nuclease and Mre11–Rad50 complex. The groups have solved the structure of a hexameric HerA ring from Sulfolobus solfataricus, and provide insight into a novel mechanism of DNA repair.