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Detecting quadruplex DNA

Detecting quadruplex DNA

Quadruplex visualisation and staining in human cell nuclei and chromosomes Credit: Jean-Paul Rodriguez and Giulia Biffi

The recent success in Shankar Balasubramanian's group, based in the  Department of Chemistry and the CRUK Cambridge Research Institute, in showing that four-stranded ‘quadruple helix’ DNA structures exist within human cells, has relied on production of anti-quadruplex DNA antibodies using technology developed by John McCafferty's group in the Department of Biochemistry. The two group leaders have just jointly published a paper online in Nature Chemistry. For the full story see the University news web site.