Together with their international collaborators, Gerard Evan's group have published a paper in Nature Communications "Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis".
Gliomas are the most common primary tumours affecting the adult central nervous system and respond poorly to standard therapy.
Myc is implicated in most human tumours and most glioblastomas have elevated Myc levels. Using the Myc dominant negative Omomyc, the teams had previously showed that Myc inhibition is a promising strategy for cancer therapy.
In this paper they validate Myc inhibition as a therapeutic strategy in preclinical studies. They found that Myc inhibition reduces proliferation, increases apoptosis and brings about the formation of multinucleated cells that then arrest or die by mitotic catastrophe, revealing a new role for Myc in the division of glioma cells.