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Post PKS Enzymes

Post PKS enzymes are also of significant interest because often the structural alterations they introduce are essential for biological activity. It is of great interest to discover the exact sequence of events and the identity of the intermediates in the overall process. For example, specific deletion of a single post PKS gene in the monensin gene cluster led to accumulation of a triene whose structure differs revealingly from the final monensin A product, as shown below.

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Peter Leadlay 2010

Herchel Smith Professor of Biochemistry, Department of Biochemistry, University of Cambridge, Telephone: (01223) 333656, Fax: (01223) 766002