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Hollfelder group

Michael Herger

PhD student
Joined the lab: January 2016
Background and Current Projects: After receiving my BSc in Interdisciplinary Sciences at ETH Zurich, I completed my MSc in October 2015 with a major in Biology and Chemistry. My master’s thesis in Prof. F. H. Arnold’s group at Caltech (Pasadena, USA) comprised the directed evolution of a tryptophan synthase beta-subunit for substrate promiscuity to allow for enzymatic synthesis of a broad range of non-canonical amino acids.
After a student internship at Roche, where I evaluated a novel affinity tag for mass-spectrometric analysis of cell surface proteins, I joined Florian Hollfelder’s group for my PhD studies. My project is in collaboration with MedImmune and aims at enhancing CRISPR-associated nucleases for genome editing by means of directed evolution.
Interests: I enjoy travelling and most outdoor sports (often in combination). Recent hobbies include cycling, bouldering, and kayaking.

Publications
[2] A. R. Buller, S. Brinkmann-Chen, D. K. Romney, M. Herger, J. Murciano-Calles, F. H. Arnold, Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation. PNAS 112, 14599-14604 (2015) read online
[1] K. Eyer, M. Herger, S. D. Krämer, P. S. Dittrich, Cell-Free Microfluidic determination of P-glycoprotein interactions with substrates and inhibitors. Pharmaceutical Research 31, 3415-3425 (2014) read online

 

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