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Hollfelder group

Mariana Rangel Pereira

PostDoc
Joined the lab: June 2016
Background and Current Projects: I graduated in Biological Sciences (B.S and B.A) at the São Paulo State University (Unesp), Brazil. My master's degree and Ph.D were obtained in Biotechnology at University of São Paulo (USP), Brazil. The topic of my Ph.D project was about functional metagenomics aiming at applications in biofuel, flavorings and bioremediation and led to the identification and characterization of new lipolytic enzymes. Part of my PhD work was done in collaboration with Marko Hyvönen at the University of Cambridge.
In my current project, metagenomic libraries from different environmental sources will be screened for lipases, laccases and proteases using high-throughput droplet-based assays. Hopefully, this work will lead to the identification and characterization of previously unrecorded biocatalysts that could prove useful for biotechnological applications.

Publications

[5] Pereira, M. R. Maester, T. C., Mercaldi, G. F.; Lemos, E. G. M.; Hyvönen, M.; Balan, A. From a metagenomic source to a high-resolution structure of a novel alkaline esterase. Applied Microbiology and Biotechnology, 2016. (submitted)

[4] Maester, T. C., Pereira, M. R., Sierra, E. G. M., Balan, A., Lemos, E. G. M. Characterization of EST3: A metagenome-derived esterase with suitable properties for biotechnological applications. Applied Microbiology and Biotechnology, 2016.

[3] Pereira, M. R., Mercaldi, G. F., Maester, T. C., Balan, A., Lemos, E. G. M. Est16, a New Esterase Isolated from a Metagenomic Library of a Microbial Consortium Specializing in Diesel Oil Degradation. PloS One, v.10, 2015.

[2] Garcia, R. A. M., Pereira, M. R., Maester, T. C., Lemos, E. G. M. Investigation, expression and molecular modeling of ORF2, a metagenomic lipolytic enzyme. Applied Biochemistry and Biotechnology, v.175, p.3875 - 3887, 2015.

[1] Pereira, M. R., Maester, T. C., Alves, L. M. C., Lemos, E. G. M. Book chapter: The use of lipolytic enzymes in biodiesel production. In: Bioenergy. Development, Research and Innovation, v.1, p. 319-339, 2012.

 

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