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Hollfelder Group

Mechanisms in Chemistry and Biology


Nature has evolved the most amazing functional biomolecules and we want to know how they work. Enzymes are the all-purpose catalysts that make the Chemistry of Life run smoothly and efficiently, under the mildest, ‘greenest’ conditions – and protein binders are involved in governing many biological processes.

The Hollfelder group is interested in gaining a fundamental understanding of the principles responsible for molecular recognition processes in chemistry and biology. We probe whether these principles enable us to describe, manipulate and ultimately make functional molecules. Using an eclectic mix of techniques we extend the mechanistic lessons learned to potential applications in biotechnology, synthetic chemistry and medicine.

The Hollfelder group has established an open-source database, DropBase, for recording and distributing microdroplet device designs. Dropbase can be found here.

Evolution of enzyme catalysts caged in biomimetic gel-shell beads

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Contact details


Dr Florian Hollfelder

Tel: +44 (0)1223 766048


Mailing address:

Department of Biochemistry
University of Cambridge
80 Tennis Court Road


Visiting address:

Sanger Building, Old Addenbrookes Site