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de la Roche Group

Thomas Foets

PhD student
Cambridge Cancer Centre PhD Scholarship

Joined the lab: October 2014

Background and Current Project: I completed my undergraduate degree in medicine at Utrecht University, the Netherlands. After receiving my B.Sc. in 2013, I investigated the role of K-ras in calcium signalling in colorectal cancer under supervision of Dr. Llewelyn Roderick at the Babraham Institute of the University of Cambridge on a BBSRC scholarship. In 2014, I joined the De la Roche laboratory to investigate the role of Wnt signalling inhibition on tumour effector functions in APC-mutated cell lines for which I graduated with a Master of Philosophy in Biological Science. I was elected a Cambridge Cancer Centre PhD scholar in 2015 to further investigate the role of Wnt signalling inhibition, specifically in human colorectal cancer organoids. Through my graduate studies, I hope to advance treatment strategies for the second most common cause of death amongst cancer patients.

Interests: I am a weightlifter and was founder of an international non-profit organisation (



Pierro C, Cook SJ, Foets TC, Bootman MD, Roderick HL. Oncogenic K-Ras suppresses IP₃-dependent Ca²⁺ release through remodelling of the isoform composition of IP₃Rs and ER luminal Ca²⁺ levels in colorectal cancer cell lines. J Cell Sci. 2014 Apr 1;127(Pt 7):1607-19. Abstract

[2] Foets TC, Weusten BL, van Es HW, Boerma D. An 84 year old man with gastric outlet obstruction. Ned Tijdschr Geneeskd. 2014. Abstract
[3] Foets TCF. Expanded Access to Non-FDA-Approved Medication in Response to a Future Epidemic [abbreviated paper for general academic audience]. Student Research Conference Proceedings, November 2014.