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Publication List

List Of Publications - Tom Blundell

Jubb HC, Higueruelo AP, Ochoa-Montaño B, Pitt WR, Ascher DB, Blundell TL. Arpeggio: A web server for calculating and visualising interatomic interactions in protein structures. J Mol Biol. 2016 Dec 10. pii: S0022-2836(16)30533-2. doi: 10.1016/j.jmb.2016.12.004. [Epub ahead of print] PMID:27964945

Jubb HC, Pandurangan AP, Turner MA, Ochoa-Montaño B, Blundell TL, Ascher DB. Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health. Prog Biophys Mol Biol. 2016 Nov 29. pii: S0079-6107(16)30031-1. doi: 10.1016/j.pbiomolbio.2016.10.002. [Epub ahead of print] Review. PMID:27913149

Mendes V, Blundell TL. Targeting tuberculosis using structure-guided fragment-based drug design. Drug Discov Today. 2016 Oct 11. pii: S1359-6446(16)30379-8. doi: 10.1016/j.drudis.2016.10.003. [Epub ahead of print] Review. PMID:27742535

Chang HH, Watanabe G, Gerodimos CA, Ochi T, Blundell TL, Jackson SP, Lieber MR. Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency. J Biol Chem. 2016 Nov 18;291(47):24377-24389. PMID:27703001 | PMCID:PMC5114395

Singh V, Donini S, Pacitto A, Sala C, Hartkoorn RC, Dhar N, Keri G, Ascher DB, Mondésert G, Vocat A, Lupien A, Sommer R, Vermet H, Lagrange S, Buechler J, Warner DF, McKinney JD, Pato J, Cole ST, Blundell TL, Rizzi M, Mizrahi V. The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis. ACS Infect Dis. 2016 Sep 8. [Epub ahead of print] PMID:27726334

Moschetti T, Sharpe T, Fischer G, Marsh ME, Ng HK, Morgan M, Scott DE, Blundell TL, R Venkitaraman A, Skidmore J, Abell C, Hyvönen M. Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J Mol Biol. 2016 Nov 20;428(23):4589-4607. doi: 10.1016/j.jmb.2016.10.009. PMID:27725183 | PMCID:PMC5117717

Park Y, Pacitto A, Bayliss T, Cleghorn LA, Wang Z, Hartman T, Arora K, Ioerger TR, Sacchettini J, Rizzi M, Donini S, Blundell TL, Ascher DB, Rhee KY, Breda A, Zhou N, Dartois V, Jonnala SR, Via LE, Mizrahi V, Epemolu O, Stojanovski L, et al. Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis. ACS Infect Dis. 2016 Oct 5. [Epub ahead of print] PMID:27704782

Luciani R, Saxena P, Surade S, Santucci M, Venturelli A, Borsari C, Marverti G, Ponterini G, Ferrari S, Blundell TL, Costi MP. Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase. J Med Chem. 2016 Oct 13;59(19):9269-9275. PMID:27589670

Herbert C, Schieborr U, Saxena K, Juraszek J, De Smet F, Alcouffe C, Bianciotto M, Saladino G, Sibrac D, Kudlinzki D, Sreeramulu S, Brown A, Rigon P, Herault JP, Lassalle G, Blundell TL, Rousseau F, Gils A, Schymkowitz J, Tompa P, Herbert JM, Carmeliet P, Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling. Cancer Cell. 2016 Jul 11;30(1):176-178. doi: 10.1016/j.ccell.2016.06.015. No abstract available. PMID:27479031

Marsh ME, Scott DE, Ehebauer MT, Abell C, Blundell TL, Hyvönen M. ATP half-sites in RadA and RAD51 recombinases bind nucleotides. FEBS Open Bio. 2016 Apr 6;6(5):372-85. doi: 10.1002/2211-5463.12052. PMID:27419043 | PMCID:PMC4856416

Pires DE, Blundell TL, Ascher DB. mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance. Sci Rep. 2016 Jul 7;6:29575. doi: 10.1038/srep29575. PMID:27384129 | PMCID:PMC4935856

Radoux CJ, Olsson TS, Pitt WR, Groom CR, Blundell TL. Identifying Interactions that Determine Fragment Binding at Protein Hotspots. J Med Chem. 2016 May 12;59(9):4314-25. doi: 10.1021/acs.jmedchem.5b01980. PMID:27043011

Scott DE, Marsh M, Blundell TL, Abell C, Hyvönen M. Structure-activity relationship of the peptide binding-motif mediating the BRCA2:RAD51 protein-protein interaction. FEBS Lett. 2016 Apr;590(8):1094-102. doi: 10.1002/1873-3468.12139. PMID:26992456 | PMCID:PMC4855620

Nikiforov PO, Surade S, Blaszczyk M, Delorme V, Brodin P, Baulard AR, Blundell TL, Abell C. A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. Org Biomol Chem. 2016 Feb 21;14(7):2318-26. doi: 10.1039/c5ob02630j. PMID:26806381 | PMCID:PMC4759522

Pires DE, Chen J, Blundell TL, Ascher DB. In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity. Sci Rep. 2016 Jan 22;6:19848. doi: 10.1038/srep19848. PMID:26797105 | PMCID:PMC4726175

Wu Q, Paul A, Su D, Mehmood S, Foo TK, Ochi T, Bunting EL, Xia B, Robinson CV, Wang B, Blundell TL. Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. Mol Cell. 2016 Feb 4;61(3):434-48. doi: 10.1016/j.molcel.2015.12.017. PMID:26778126 | PMCID:PMC4747905

Winter A, Sigurdardottir AG, DiCara D, Valenti G, Blundell TL, Gherardi E. Developing Antagonists for the Met-HGF/SF Protein-Protein Interaction Using a Fragment-Based Approach. Mol Cancer Ther. 2016 Jan;15(1):3-14. doi: 10.1158/1535-7163.MCT-15-0446. PMID:26712116

Pacitto A, Ascher DB, Wong LH, Blaszczyk BK, Nookala RK, Zhang N, Dokudovskaya S, Levine TP, Blundell TL. Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein. Open Biol. 2015 Dec;5(12):150174. doi: 10.1098/rsob.150174. PMID:26631379 | PMCID:PMC4703059

Mendes V, Blaszczyk M, Maranha A, Empadinhas N, Blundell TL. Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism. Sci Rep. 2015 Nov 30;5:17144. doi: 10.1038/srep17144. PMID:26616850 | PMCID:PMC4663749

Hung AW, Silvestre HL, Wen S, George GP, Boland J, Blundell TL, Ciulli A, Abell C. Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis. ChemMedChem. 2016 Jan 5;11(1):38-42. doi: 10.1002/cmdc.201500414. PMID:26486566 | PMCID:PMC4949533

Metri R, Hariharaputran S, Ramakrishnan G, Anand P, Raghavender US, Ochoa-Montaño B, Higueruelo AP, Sowdhamini R, Chandra NR, Blundell TL, Srinivasan N. SInCRe-structural interactome computational resource for Mycobacterium tuberculosis. Database (Oxford). 2015 Jun 30;2015:bav060. doi: 10.1093/database/bav060. PMID:26130660 | PMCID:PMC4485431

Blaszczyk M, Harmer NJ, Chirgadze DY, Ascher DB, Blundell TL. Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors. Prog Biophys Mol Biol. 2015 Sep;118(3):103-11. doi: 10.1016/j.pbiomolbio.2015.04.007. Review. PMID:25957048 | PMCID:PMC4832006

Jafri M, Wake NC, Ascher DB, Pires DE, Gentle D, Morris MR, Rattenberry E, Simpson MA, Trembath RC, Weber A, Woodward ER, Donaldson A, Blundell TL, Latif F, Maher ER. Germline Mutations in the CDKN2B Tumor Suppressor Gene Predispose to Renal Cell Carcinoma. Cancer Discov. 2015 Jul;5(7):723-9. doi: 10.1158/2159-8290.CD-14-1096. PMID:25873077

Pires DE, Blundell TL, Ascher DB. pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures. J Med Chem. 2015 May 14;58(9):4066-72. doi: 10.1021/acs.jmedchem.5b00104. PMID:25860834 | PMCID:PMC4434528

Ochoa-Montaño B, Mohan N, Blundell TL. CHOPIN: a web resource for the structural and functional proteome of Mycobacterium tuberculosis. Database (Oxford). 2015 Mar 31;2015. pii: bav026. doi: 10.1093/database/bav026. PMID:25833954 | PMCID:PMC4381106

Nemethova M, Radvanszky J, Kadasi L, Ascher DB, Pires DE, Blundell TL, Porfirio B, Mannoni A, Santucci A, Milucci L, Sestini S, Biolcati G, Sorge F, Aurizi C, Aquaron R, Alsbou M, Lourenço CM, Ramadevi K, Ranganath LR, Gallagher JA, van Kan C, Hall AK, e Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on 'black bone disease' in Italy. Eur J Hum Genet. 2016 Jan;24(1):66-72. doi: 10.1038/ejhg.2015.60. PMID:25804398 | PMCID:PMC4795215

Murray JE, van der Burg M, IJspeert H, Carroll P, Wu Q, Ochi T, Leitch A, Miller ES, Kysela B, Jawad A, Bottani A, Brancati F, Cappa M, Cormier-Daire V, Deshpande C, Faqeih EA, Graham GE, Ranza E, Blundell TL, Jackson AP, Stewart GS, Bicknell LS. Mutations in the NHEJ component XRCC4 cause primordial dwarfism. Am J Hum Genet. 2015 Mar 5;96(3):412-24. doi: 10.1016/j.ajhg.2015.01.013. PMID:25728776 | PMCID:PMC4375537

Wu Q, Jubb H, Blundell TL. Phosphopeptide interactions with BRCA1 BRCT domains: More than just a motif. Prog Biophys Mol Biol. 2015 Mar;117(2-3):143-8. doi: 10.1016/j.pbiomolbio.2015.02.003. Review. PMID:25701377 | PMCID:PMC4728184

Usher JL, Ascher DB, Pires DE, Milan AM, Blundell TL, Ranganath LR. Analysis of HGD Gene Mutations in Patients with Alkaptonuria from the United Kingdom: Identification of Novel Mutations. JIMD Rep. 2015;24:3-11. doi: 10.1007/8904_2014_380. PMID:25681086 | PMCID:PMC4582018

Jubb H, Blundell TL, Ascher DB. Flexibility and small pockets at protein-protein interfaces: New insights into druggability. Prog Biophys Mol Biol. 2015 Oct;119(1):2-9. doi: 10.1016/j.pbiomolbio.2015.01.009. Review. PMID:25662442 | PMCID:PMC4726663

Ochi T, Blackford AN, Coates J, Jhujh S, Mehmood S, Tamura N, Travers J, Wu Q, Draviam VM, Robinson CV, Blundell TL, Jackson SP. DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair. Science. 2015 Jan 9;347(6218):185-8. doi: 10.1126/science.1261971. PMID:25574025 | PMCID:PMC4338599

Scott DE, Coyne AG, Venkitaraman A, Blundell TL, Abell C, Hyvönen M. Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases. ChemMedChem. 2015 Feb;10(2):296-303. doi: 10.1002/cmdc.201402428. PMID:25470112 | PMCID:PMC4506530

Ramakrishnan G, Ochoa-Montaño B, Raghavender US, Mudgal R, Joshi AG, Chandra NR, Sowdhamini R, Blundell TL, Srinivasan N. Enriching the annotation of Mycobacterium tuberculosis H37Rv proteome using remote homology detection approaches: insights into structure and function. Tuberculosis (Edinb). 2015 Jan;95(1):14-25. doi: 10.1016/j.tube.2014.10.009. Review. PMID:25467293

Hepburn L, Prajsnar TK, Klapholz C, Moreno P, Loynes CA, Ogryzko NV, Brown K, Schiebler M, Hegyi K, Antrobus R, Hammond KL, Connolly J, Ochoa B, Bryant C, Otto M, Surewaard B, Seneviratne SL, Grogono DM, Cachat J, Ny T, Kaser A, Török ME, et al. Innate immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus. Science. 2014 Oct 31;346(6209):641-6. doi: 10.1126/science.1258705. PMID:25359976 | PMCID:PMC4255479

Lewis TE, Sillitoe I, Andreeva A, Blundell TL, Buchan DW, Chothia C, Cozzetto D, Dana JM, Filippis I, Gough J, Jones DT, Kelley LA, Kleywegt GJ, Minneci F, Mistry J, Murzin AG, Ochoa-Montaño B, Oates ME, Punta M, Rackham OJ, Stahlhacke J, Sternberg MJ, e Genome3D: exploiting structure to help users understand their sequences. Nucleic Acids Res. 2015 Jan;43(Database issue):D382-6. doi: 10.1093/nar/gku973. PMID:25348407 | PMCID:PMC4384030

Pires DE, Blundell TL, Ascher DB. Platinum: a database of experimentally measured effects of mutations on structurally defined protein-ligand complexes. Nucleic Acids Res. 2015 Jan;43(Database issue):D387-91. doi: 10.1093/nar/gku966. PMID:25324307 | PMCID:PMC4384026

Pitt WR, Montalvão RW, Blundell TL. Polyphony: superposition independent methods for ensemble-based drug discovery. BMC Bioinformatics. 2014 Sep 30;15:324. doi: 10.1186/1471-2105-15-324. PMID:25265915 | PMCID:PMC4261739

Howard NI, Dias MV, Peyrot F, Chen L, Schmidt MF, Blundell TL, Abell C. Design and structural analysis of aromatic inhibitors of type II dehydroquinase from Mycobacterium tuberculosis. ChemMedChem. 2015 Jan;10(1):116-33. doi: 10.1002/cmdc.201402298. PMID:25234229

Arora K, Ochoa-Montaño B, Tsang PS, Blundell TL, Dawes SS, Mizrahi V, Bayliss T, Mackenzie CJ, Cleghorn LA, Ray PC, Wyatt PG, Uh E, Lee J, Barry CE 3rd, Boshoff HI. Respiratory flexibility in response to inhibition of cytochrome C oxidase in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2014 Nov;58(11):6962-5. doi: 10.1128/AAC.03486-14. PMID:25155596 | PMCID:PMC4249445

Mageed SN, Cunningham F, Hung AW, Silvestre HL, Wen S, Blundell TL, Abell C, McConkey GA. Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy. Antimicrob Agents Chemother. 2014 Nov;58(11):6345-53. doi: 10.1128/AAC.02640-14. PMID:25049241 | PMCID:PMC4249369

Gossage L, Pires DE, Olivera-Nappa Á, Asenjo J, Bycroft M, Blundell TL, Eisen T. An integrated computational approach can classify VHL missense mutations according to risk of clear cell renal carcinoma. Hum Mol Genet. 2014 Nov 15;23(22):5976-88. doi: 10.1093/hmg/ddu321. PMID:24969085 | PMCID:PMC4204774

Pires DE, Ascher DB, Blundell TL. DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach. Nucleic Acids Res. 2014 Jul;42(Web Server issue):W314-9. doi: 10.1093/nar/gku411. PMID:24829462 | PMCID:PMC4086143

Webb ME, Yorke BA, Kershaw T, Lovelock S, Lobley CM, Kilkenny ML, Smith AG, Blundell TL, Pearson AR, Abell C. Threonine 57 is required for the post-translational activation of Escherichia coli aspartate α-decarboxylase. Acta Crystallogr D Biol Crystallogr. 2014 Apr;70(Pt 4):1166-72. doi: 10.1107/S1399004713034275. PMID:24699660 | PMCID:PMC3975893

Brown A, Adam LE, Blundell TL. The crystal structure of fibroblast growth factor 18 (FGF18). Protein Cell. 2014 May;5(5):343-7. doi: 10.1007/s13238-014-0033-4. No abstract available. PMID:24668462 | PMCID:PMC3996155

Ochi T, Wu Q, Blundell TL. The spatial organization of non-homologous end joining: from bridging to end joining. DNA Repair (Amst). 2014 May;17:98-109. doi: 10.1016/j.dnarep.2014.02.010. PMID:24636752 | PMCID:PMC4037875

Ballester PJ, Schreyer A, Blundell TL. Does a more precise chemical description of protein-ligand complexes lead to more accurate prediction of binding affinity? J Chem Inf Model. 2014 Mar 24;54(3):944-55. doi: 10.1021/ci500091r. PMID:24528282 | PMCID:PMC3966527

Surade S, Ty N, Hengrung N, Lechartier B, Cole ST, Abell C, Blundell TL. A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR. Biochem J. 2014 Mar 1;458(2):387-94. doi: 10.1042/BJ20131127. PMID:24313835

Tófoli de Araújo F, Bolanos-Garcia VM, Pereira CT, Sanches M, Oshiro EE, Ferreira RC, Chigardze DY, Barbosa JA, de Souza Ferreira LC, Benedetti CE, Blundell TL, Balan A. Structural and physiological analyses of the alkanesulphonate-binding protein (SsuA) of the citrus pathogen Xanthomonas citri. PLoS One. 2013 Nov 25;8(11):e80083. doi: 10.1371/journal.pone.0080083. PMID:24282519 | PMCID:PMC3839906

Pires DE, Ascher DB, Blundell TL. mCSM: predicting the effects of mutations in proteins using graph-based signatures. Bioinformatics. 2014 Feb 1;30(3):335-42. doi: 10.1093/bioinformatics/btt691. PMID:24281696 | PMCID:PMC3904523

Dias MV, Tyrakis P, Domingues RR, Paes Leme AF, Blundell TL. Mycobacterium tuberculosis dihydrofolate reductase reveals two conformational states and a possible low affinity mechanism to antifolate drugs. Structure. 2014 Jan 7;22(1):94-103. doi: 10.1016/j.str.2013.09.022. PMID:24210757

Silvestre HL, Blundell TL, Abell C, Ciulli A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):12984-9. doi: 10.1073/pnas.1304045110. PMID:23872845 | PMCID:PMC3740835

Schreyer AM, Blundell TL. CREDO: a structural interactomics database for drug discovery. Database (Oxford). 2013 Jul 18;2013:bat049. doi: 10.1093/database/bat049. PMID:23868908 | PMCID:PMC3715132

Arendse L, Blundell TL, Blackburn J. Combining in silico protein stability calculations with structure-function relationships to explore the effect of polymorphic variation on cytochrome P450 drug metabolism. Curr Drug Metab. 2013 Sep;14(7):745-63. PMID:23826828

Higueruelo AP, Jubb H, Blundell TL. TIMBAL v2: update of a database holding small molecules modulating protein-protein interactions. Database (Oxford). 2013 Jun 13;2013:bat039. doi: 10.1093/database/bat039. PMID:23766369 | PMCID:PMC3681332

Higueruelo AP, Jubb H, Blundell TL. Protein-protein interactions as druggable targets: recent technological advances. Curr Opin Pharmacol. 2013 Oct;13(5):791-6. doi: 10.1016/j.coph.2013.05.009. Review. PMID:23735579

Brown A, Robinson CJ, Gallagher JT, Blundell TL. Cooperative heparin-mediated oligomerization of fibroblast growth factor-1 (FGF1) precedes recruitment of FGFR2 to ternary complexes. Biophys J. 2013 Apr 16;104(8):1720-30. doi: 10.1016/j.bpj.2013.02.051. PMID:23601319 | PMCID:PMC3628569

Herbert C, Schieborr U, Saxena K, Juraszek J, De Smet F, Alcouffe C, Bianciotto M, Saladino G, Sibrac D, Kudlinzki D, Sreeramulu S, Brown A, Rigon P, Herault JP, Lassalle G, Blundell TL, Rousseau F, Gils A, Schymkowitz J, Tompa P, Herbert JM, Carmeliet P, Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling. Cancer Cell. 2013 Apr 15;23(4):489-501. doi: 10.1016/j.ccr.2013.02.018. PMID:23597563

Ochi T, Gu X, Blundell TL. Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair. Structure. 2013 Apr 2;21(4):672-9. doi: 10.1016/j.str.2013.02.014. PMID:23523427 | PMCID:PMC3664939

Scott DE, Ehebauer MT, Pukala T, Marsh M, Blundell TL, Venkitaraman AR, Abell C, Hyvönen M. Using a fragment-based approach to target protein-protein interactions. Chembiochem. 2013 Feb 11;14(3):332-42. doi: 10.1002/cbic.201200521. PMID:23344974 | PMCID:PMC3594973

Higueruelo AP, Schreyer A, Bickerton GR, Blundell TL, Pitt WR. What can we learn from the evolution of protein-ligand interactions to aid the design of new therapeutics? PLoS One. 2012;7(12):e51742. doi: 10.1371/journal.pone.0051742. PMID:23240060 | PMCID: PMC3519888

Lewis TE, Sillitoe I, Andreeva A, Blundell TL, Buchan DW, Chothia C, Cuff A, Dana JM, Filippis I, Gough J, Hunter S, Jones DT, Kelley LA, Kleywegt GJ, Minneci F, Mitchell A, Murzin AG, Ochoa-Montaño B, Rackham OJ, Smith J, Sternberg MJ, Velankar S, et al Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains. Nucleic Acids Res. 2013 Jan;41(Database issue):D499-507. doi: 10.1093/nar/gks1266. PMID:23203986 | PMCID:PMC3531217

Schmidt MF, Korb O, Howard NI, Dias MV, Blundell TL, Abell C. Discovery of Schaeffer's acid analogues as lead structures of mycobacterium tuberculosis type II dehydroquinase using a rational drug design approach. ChemMedChem. 2013 Jan;8(1):54-8. doi: 10.1002/cmdc.201200508. PMID:23169689

Schreyer AM, Blundell T. USRCAT: real-time ultrafast shape recognition with pharmacophoric constraints. J Cheminform. 2012 Nov 6;4(1):27. doi: 10.1186/1758-2946-4-27. PMID:23131020 | PMCID:PMC3505738

Blundell TL. Professor Dame Louise Napier Johnson (26 September 1940-25 September 2012). Acta Crystallogr D Biol Crystallogr. 2012 Nov;68(Pt 11):1588-90. doi: 10.1107/S0907444912042965. No abstract available. PMID:23090409

Thebault P, Chirgadze DY, Dou Z, Blundell TL, Elowe S, Bolanos-Garcia VM. Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint). Biochem J. 2012 Dec 15;448(3):321-8. doi: 10.1042/BJ20121448. PMID:23067341

Nookala RK, Langemeyer L, Pacitto A, Ochoa-Montaño B, Donaldson JC, Blaszczyk BK, Chirgadze DY, Barr FA, Bazan JF, Blundell TL. Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer. Open Biol. 2012 Aug;2(8):120071. doi: 10.1098/rsob.120071. PMID:22977732 | PMCID:PMC3438538

Winter A, Higueruelo AP, Marsh M, Sigurdardottir A, Pitt WR, Blundell TL. Biophysical and computational fragment-based approaches to targeting protein-protein interactions: applications in structure-guided drug discovery. Q Rev Biophys. 2012 Nov;45(4):383-426. doi: 10.1017/S0033583512000108. Review. PMID:22971516

Bolanos-Garcia VM, Nilsson J, Blundell TL. The architecture of the BubR1 tetratricopeptide tandem repeat defines a protein motif underlying mitotic checkpoint-kinetochore communication. Bioarchitecture. 2012 Jan 1;2(1):23-27. PMID:22754625 | PMCID:PMC3383715

Ochi T, Wu Q, Chirgadze DY, Grossmann JG, Bolanos-Garcia VM, Blundell TL. Structural insights into the role of domain flexibility in human DNA ligase IV. Structure. 2012 Jul 3;20(7):1212-22. doi: 10.1016/j.str.2012.04.012. PMID:22658747 | PMCID:PMC3391681

Bolanos-Garcia VM, Wu Q, Ochi T, Chirgadze DY, Sibanda BL, Blundell TL. Spatial and temporal organization of multi-protein assemblies: achieving sensitive control in information-rich cell-regulatory systems. Philos Trans A Math Phys Eng Sci. 2012 Jun 28;370(1969):3023-39. doi: 10.1098/rsta.2011.0268. PMID:22615474

Bailey D, Carpenter EP, Coker A, Coker S, Read J, Jones AT, Erskine P, Aguilar CF, Badasso M, Toldo L, Rippmann F, Sanz-Aparicio J, Albert A, Blundell TL, Roberts NB, Wood SP, Cooper JB. An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases. Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):541-52. doi: 10.1107/S0907444912004817. PMID:22525752

Webb ME, Lobley CM, Soliman F, Kilkenny ML, Smith AG, Blundell TL, Abell C. Structure of Escherichia coli aspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1;68(Pt 4):414-7. doi: 10.1107/S1744309112009487. PMID:22505409 | PMCID:PMC3325809

Jubb H, Higueruelo AP, Winter A, Blundell TL. Structural biology and drug discovery for protein-protein interactions. Trends Pharmacol Sci. 2012 May;33(5):241-8. doi: 10.1016/j.tips.2012.03.006. Review. PMID:22503442

Surade S, Blundell TL. Structural biology and drug discovery of difficult targets: the limits of ligandability. Chem Biol. 2012 Jan 27;19(1):42-50. doi: 10.1016/j.chembiol.2011.12.013. Review. PMID:22284353

Lee S, Thebault P, Freschi L, Beaufils S, Blundell TL, Landry CR, Bolanos-Garcia VM, Elowe S. Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases. J Biol Chem. 2012 Feb 17;287(8):5988-6001. doi: 10.1074/jbc.M111.307355. PMID:22187426 | PMCID:PMC3285366

Bolanos-Garcia VM, Lischetti T, Matak-Vinković D, Cota E, Simpson PJ, Chirgadze DY, Spring DR, Robinson CV, Nilsson J, Blundell TL. Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site. Structure. 2011 Nov 9;19(11):1691-700. doi: 10.1016/j.str.2011.09.017. Erratum in: Structure. 2011 Dec 7;19(12):1895. PMID:22000412 | PMCID:PMC3267040

Wu Q, Ochi T, Matak-Vinkovic D, Robinson CV, Chirgadze DY, Blundell TL. Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions. Biochem Soc Trans. 2011 Oct;39(5):1387-92, suppl 2 p following 1392. doi: 10.1042/BST0391387. PMID:21936820

Abdel-Rahman N, Martinez-Arias A, Blundell TL. Probing the druggability of protein-protein interactions: targeting the Notch1 receptor ankyrin domain using a fragment-based approach. Biochem Soc Trans. 2011 Oct;39(5):1327-33. doi: 10.1042/BST0391327. PMID:21936810

Bickerton GR, Higueruelo AP, Blundell TL. Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database. BMC Bioinformatics. 2011 Jul 29;12:313. doi: 10.1186/1471-2105-12-313. PMID:21801404 | PMCID:PMC3161047

Blundell TL, Hendrickson WA. What is 'current opinion' in structural biology? Curr Opin Struct Biol. 2011 Aug;21(4):447-9. doi: 10.1016/j.sbi.2011.06.005. No abstract available. PMID:21795039

Worth CL, Preissner R, Blundell TL. SDM--a server for predicting effects of mutations on protein stability and malfunction. Nucleic Acids Res. 2011 Jul;39(Web Server issue):W215-22. doi: 10.1093/nar/gkr363. PMID:21593128 | PMCID:PMC3125769

Dias MV, Snee WC, Bromfield KM, Payne RJ, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. Biochem J. 2011 Jun 15;436(3):729-39. doi: 10.1042/BJ20110002. PMID:21410435

Gong S, Worth CL, Cheng TM, Blundell TL. Meet me halfway: when genomics meets structural bioinformatics. J Cardiovasc Transl Res. 2011 Jun;4(3):281-303. doi: 10.1007/s12265-011-9259-1. PMID:21350909

Bolanos-Garcia VM, Blundell TL. BUB1 and BUBR1: multifaceted kinases of the cell cycle. Trends Biochem Sci. 2011 Mar;36(3):141-50. doi: 10.1016/j.tibs.2010.08.004. Review. PMID:20888775 | PMCID:PMC3061984

Ochi T, Sibanda BL, Wu Q, Chirgadze DY, Bolanos-Garcia VM, Blundell TL. Structural biology of DNA repair: spatial organisation of the multicomponent complexes of nonhomologous end joining. J Nucleic Acids. 2010 Aug 25;2010. pii: 621695. doi: 10.4061/2010/621695. PMID:20862368 | PMCID:PMC2938450

Sinha Roy R, Soni S, Harfouche R, Vasudevan PR, Holmes O, de Jonge H, Rowe A, Paraskar A, Hentschel DM, Chirgadze D, Blundell TL, Gherardi E, Mashelkar RA, Sengupta S. Coupling growth-factor engineering with nanotechnology for therapeutic angiogenesis. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13608-13. doi: 10.1073/pnas.1006007107. PMID:20639469 | PMCID:PMC2922257

Worth CL, Blundell TL. On the evolutionary conservation of hydrogen bonds made by buried polar amino acids: the hidden joists, braces and trusses of protein architecture. BMC Evol Biol. 2010 May 31;10:161. doi: 10.1186/1471-2148-10-161. PMID:20513243 | PMCID:PMC2892493

Murray CW, Blundell TL. Structural biology in fragment-based drug design. Curr Opin Struct Biol. 2010 Aug;20(4):497-507. doi: 10.1016/j.sbi.2010.04.003. Review. PMID:20471246

Dias MV, Huang F, Chirgadze DY, Tosin M, Spiteller D, Dry EF, Leadlay PF, Spencer JB, Blundell TL. Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK. J Biol Chem. 2010 Jul 16;285(29):22495-504. doi: 10.1074/jbc.M110.107177. PMID:20430898 | PMCID:PMC2903362

Sledz P, Silvestre HL, Hung AW, Ciulli A, Blundell TL, Abell C. Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase. J Am Chem Soc. 2010 Apr 7;132(13):4544-5. doi: 10.1021/ja100595u. PMID:20232910 | PMCID:PMC4441724

D'Arcy S, Davies OR, Blundell TL, Bolanos-Garcia VM. Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition. J Biol Chem. 2010 May 7;285(19):14764-76. doi: 10.1074/jbc.M109.082016. PMID:20220147 | PMCID:PMC2863239

Gong S, Blundell TL. Structural and functional restraints on the occurrence of single amino acid variations in human proteins. PLoS One. 2010 Feb 12;5(2):e9186. doi: 10.1371/journal.pone.0009186. PMID:20169194 | PMCID:PMC2820541

Sridharan S, Howard N, Kerbarh O, BÅ‚aszczyk M, Abell C, Blundell TL. Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes. J Mol Biol. 2010 Mar 19;397(1):290-300. doi: 10.1016/j.jmb.2010.01.019. PMID:20079748

Sibanda BL, Chirgadze DY, Blundell TL. Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats. Nature. 2010 Jan 7;463(7277):118-21. doi: 10.1038/nature08648. PMID:20023628 | PMCID:PMC2811870

Reis NM, Chirgadze DY, Blundell TL, Mackley MR. The effect of protein-precipitant interfaces and applied shear on the nucleation and growth of lysozyme crystals. Acta Crystallogr D Biol Crystallogr. 2009 Nov;65(Pt 11):1127-39. doi: 10.1107/S0907444909031527. PMID:19923710 | PMCID:PMC2777168

Blundell TL, Bolanos-Garcia VM. Targeting protein interactions of p53 for therapeutic intervention: success in a frustrated landscape. Cell Cycle. 2009 Nov 15;8(22):3631-2. No abstract available. PMID:19875920

Higueruelo AP, Schreyer A, Bickerton GR, Pitt WR, Groom CR, Blundell TL. Atomic interactions and profile of small molecules disrupting protein-protein interfaces: the TIMBAL database. Chem Biol Drug Des. 2009 Nov;74(5):457-67. doi: 10.1111/j.1747-0285.2009.00889.x. PMID:19811506

Ricketts CJ, Forman JR, Rattenberry E, Bradshaw N, Lalloo F, Izatt L, Cole TR, Armstrong R, Kumar VK, Morrison PJ, Atkinson AB, Douglas F, Ball SG, Cook J, Srirangalingam U, Killick P, Kirby G, Aylwin S, Woodward ER, Evans DG, Hodgson SV, Murday V, et al. Tumor risks and genotype-phenotype-proteotype analysis in 358 patients with germline mutations in SDHB and SDHD. Hum Mutat. 2010 Jan;31(1):41-51. doi: 10.1002/humu.21136. PMID:19802898

Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C. Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. Angew Chem Int Ed Engl. 2009;48(45):8452-6. doi: 10.1002/anie.200903821. No abstract available. PMID:19780086

Lee S, Brown A, Pitt WR, Higueruelo AP, Gong S, Bickerton GR, Schreyer A, Tanramluk D, Baylay A, Blundell TL. Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics. Mol Biosyst. 2009 Dec;5(12):1456-72. doi: 10.1039/B906402h. Review. PMID:19763326

Worth CL, Gong S, Blundell TL. Structural and functional constraints in the evolution of protein families. Nat Rev Mol Cell Biol. 2009 Oct;10(10):709-20. doi: 10.1038/nrm2762. Review. PMID:19756040

Gong S, Worth CL, Bickerton GR, Lee S, Tanramluk D, Blundell TL. Structural and functional restraints in the evolution of protein families and superfamilies. Biochem Soc Trans. 2009 Aug;37(Pt 4):727-33. doi: 10.1042/BST0370727. Review. PMID:19614584

Truman AW, Dias MV, Wu S, Blundell TL, Huang F, Spencer JB. Chimeric glycosyltransferases for the generation of hybrid glycopeptides. Chem Biol. 2009 Jun 26;16(6):676-85. doi: 10.1016/j.chembiol.2009.04.013. PMID:19549605

Tanramluk D, Schreyer A, Pitt WR, Blundell TL. On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine. Chem Biol Drug Des. 2009 Jul;74(1):16-24. doi: 10.1111/j.1747-0285.2009.00832.x. PMID:19519740 | PMCID:PMC2737611

Appert A, Nam CH, Lobato N, Priego E, Miguel RN, Blundell T, Drynan L, Sewell H, Tanaka T, Rabbitts T. Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia. Cancer Res. 2009 Jun 1;69(11):4784-90. doi: 10.1158/0008-5472.CAN-08-4774. PMID:19487290 | PMCID:PMC2690635

Lee S, Blundell TL. Ulla: a program for calculating environment-specific amino acid substitution tables. Bioinformatics. 2009 Aug 1;25(15):1976-7. doi: 10.1093/bioinformatics/btp300. PMID:19417059 | PMCID:PMC2712337

Forman JR, Worth CL, Bickerton GR, Eisen TG, Blundell TL. Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis. Proteins. 2009 Oct;77(1):84-96. doi: 10.1002/prot.22419. PMID:19408298

Lee S, Blundell TL. BIPA: a database for protein-nucleic acid interaction in 3D structures. Bioinformatics. 2009 Jun 15;25(12):1559-60. doi: 10.1093/bioinformatics/btp243. PMID:19357098

Schreyer A, Blundell T. CREDO: a protein-ligand interaction database for drug discovery. Chem Biol Drug Des. 2009 Feb;73(2):157-67. doi: 10.1111/j.1747-0285.2008.00762.x. PMID:19207418

Karmali AM, Blundell TL, Furnham N. Model-building strategies for low-resolution X-ray crystallographic data. Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):121-7. doi: 10.1107/S0907444908040006. PMID:19171966 | PMCID:PMC2631632

Bolanos-Garcia VM, Kiyomitsu T, D'Arcy S, Chirgadze DY, Grossmann JG, Matak-Vinkovic D, Venkitaraman AR, Yanagida M, Robinson CV, Blundell TL. The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores. Structure. 2009 Jan 14;17(1):105-16. doi: 10.1016/j.str.2008.10.015. PMID:19141287 | PMCID:PMC2683949

Montalvao RW, Cavalli A, Salvatella X, Blundell TL, Vendruscolo M. Structure determination of protein-protein complexes using NMR chemical shifts: case of an endonuclease colicin-immunity protein complex. J Am Chem Soc. 2008 Nov 26;130(47):15990-6. doi: 10.1021/ja805258z. PMID:18980319

Cheng TM, Blundell TL, Fernandez-Recio J. Structural assembly of two-domain proteins by rigid-body docking. BMC Bioinformatics. 2008 Oct 16;9:441. doi: 10.1186/1471-2105-9-441. PMID:18925951 | PMCID:PMC2579442

Worth CL, Blundell TL. Satisfaction of hydrogen-bonding potential influences the conservation of polar sidechains. Proteins. 2009 May 1;75(2):413-29. doi: 10.1002/prot.22248. PMID:18837037

Gong S, Blundell TL. Discarding functional residues from the substitution table improves predictions of active sites within three-dimensional structures. PLoS Comput Biol. 2008 Oct 3;4(10):e1000179. doi: 10.1371/journal.pcbi.1000179. PMID:18833291 | PMCID:PMC2527532

Ciulli A, Scott DE, Ando M, Reyes F, Saldanha SA, Tuck KL, Chirgadze DY, Blundell TL, Abell C. Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate. Chembiochem. 2008 Nov 3;9(16):2606-11. doi: 10.1002/cbic.200800437. No abstract available. PMID:18821554 | PMCID:PMC4441726

Cheng TM, Lu YE, Vendruscolo M, Lio' P, Blundell TL. Prediction by graph theoretic measures of structural effects in proteins arising from non-synonymous single nucleotide polymorphisms. PLoS Comput Biol. 2008 Jul 25;4(7):e1000135. doi: 10.1371/journal.pcbi.1000135. PMID:18654622 | PMCID:PMC2447880

Núñez Miguel R, Sanders J, Chirgadze DY, Blundell TL, Furmaniak J, Rees Smith B. FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity. J Mol Endocrinol. 2008 Sep;41(3):145-64. doi: 10.1677/JME-08-0040. PMID:18606720

Goodger SJ, Robinson CJ, Murphy KJ, Gasiunas N, Harmer NJ, Blundell TL, Pye DA, Gallagher JT. Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms. J Biol Chem. 2008 May 9;283(19):13001-8. doi: 10.1074/jbc.M704531200. PMID:18281281

Furnham N, de Bakker PI, Gore S, Burke DF, Blundell TL. Comparative modelling by restraint-based conformational sampling. BMC Struct Biol. 2008 Jan 31;8:7. doi: 10.1186/1472-6807-8-7. PMID:18237407 | PMCID:PMC2275734

Worth CL, Bickerton GR, Schreyer A, Forman JR, Cheng TM, Lee S, Gong S, Burke DF, Blundell TL. A structural bioinformatics approach to the analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) and their relation to disease. J Bioinform Comput Biol. 2007 Dec;5(6):1297-318. PMID:18172930

Li Y, Chirgadze DY, Bolanos-Garcia VM, Sibanda BL, Davies OR, Ahnesorg P, Jackson SP, Blundell TL. Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ. EMBO J. 2008 Jan 9;27(1):290-300. PMID:18046455 | PMCID:PMC2104711

Blundell T. New dimensions of structural proteomics: exploring chemical and biological space. Structure. 2007 Nov;15(11):1342-3. No abstract available. PMID:17997956

King JD, Harmer NJ, Preston A, Palmer CM, Rejzek M, Field RA, Blundell TL, Maskell DJ. Predicting protein function from structure--the roles of short-chain dehydrogenase/reductase enzymes in Bordetella O-antigen biosynthesis. J Mol Biol. 2007 Nov 30;374(3):749-63. PMID:17950751 | PMCID:PMC2279256

Burke DF, Worth CL, Priego EM, Cheng T, Smink LJ, Todd JA, Blundell TL. Genome bioinformatic analysis of nonsynonymous SNPs. BMC Bioinformatics. 2007 Aug 20;8:301. PMID:17708757 | PMCID:PMC1978506

Harmer NJ, King JD, Palmer CM, Preston A, Maskell DJ, Blundell TL. Cloning, expression, purification and preliminary crystallographic analysis of the short-chain dehydrogenase enzymes WbmF, WbmG and WbmH from Bordetella bronchiseptica. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt 8):711-5. PMID:17671375 | PMCID:PMC2335155

Sanders J, Chirgadze DY, Sanders P, Baker S, Sullivan A, Bhardwaja A, Bolton J, Reeve M, Nakatake N, Evans M, Richards T, Powell M, Miguel RN, Blundell TL, Furmaniak J, Smith BR. Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody. Thyroid. 2007 May;17(5):395-410. PMID:17542669

Cheng TM, Blundell TL, Fernandez-Recio J. pyDock: electrostatics and desolvation for effective scoring of rigid-body protein-protein docking. Proteins. 2007 Aug 1;68(2):503-15. PMID:17444519

Gore SP, Karmali AM, Blundell TL. Rappertk: a versatile engine for discrete restraint-based conformational sampling of macromolecules. BMC Struct Biol. 2007 Mar 21;7:13. PMID:17376228 | PMCID:PMC1847436

Smith RE, Lovell SC, Burke DF, Montalvao RW, Blundell TL. Andante: reducing side-chain rotamer search space during comparative modeling using environment-specific substitution probabilities. Bioinformatics. 2007 May 1;23(9):1099-105. PMID:17341496

Kerbarh O, Ciulli A, Chirgadze DY, Blundell TL, Abell C. Nucleophile selectivity of chorismate-utilizing enzymes. Chembiochem. 2007 Apr 16;8(6):622-4. No abstract available. PMID:17335098

Ciulli A, Lobley CM, Tuck KL, Smith AG, Blundell TL, Abell C. pH-tuneable binding of 2'-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study. Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):171-8. PMID:17242510 | PMCID:PMC2483484

Ciulli A, Chirgadze DY, Smith AG, Blundell TL, Abell C. Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativity. J Biol Chem. 2007 Mar 16;282(11):8487-97. PMID:17229734

Bolanos-Garcia VM, Fernandez-Recio J, Allende JE, Blundell TL. Identifying interaction motifs in CK2beta--a ubiquitous kinase regulatory subunit. Trends Biochem Sci. 2006 Dec;31(12):654-61. PMID:17084631

Blundell TL, Fernández-Recio J. Cell biology: brief encounters bolster contacts. Nature. 2006 Nov 16;444(7117):279-80. No abstract available. PMID:17051147

Furnham N, Doré AS, Chirgadze DY, de Bakker PI, Depristo MA, Blundell TL. Knowledge-based real-space explorations for low-resolution structure determination. Structure. 2006 Aug;14(8):1313-20. PMID:16905105

Popovic B, Tang X, Chirgadze DY, Huang F, Blundell TL, Spencer JB. Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis. Proteins. 2006 Oct 1;65(1):220-30. PMID:16894611

Ciulli A, Williams G, Smith AG, Blundell TL, Abell C. Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods. J Med Chem. 2006 Aug 10;49(16):4992-5000. PMID:16884311

Ryu EK, Cho KJ, Kim JK, Harmer NJ, Blundell TL, Kim KH. Expression and purification of recombinant human fibroblast growth factor receptor in Escherichia coli. Protein Expr Purif. 2006 Sep;49(1):15-22. PMID:16750394

Hoskins J, Lovell S, Blundell TL. An algorithm for predicting protein-protein interaction sites: Abnormally exposed amino acid residues and secondary structure elements. Protein Sci. 2006 May;15(5):1017-29. PMID:16641487 | PMCID:PMC2242518

Gherardi E, Sandin S, Petoukhov MV, Finch J, Youles ME, Ofverstedt LG, Miguel RN, Blundell TL, Vande Woude GF, Skoglund U, Svergun DI. Structural basis of hepatocyte growth factor/scatter factor and MET signalling. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4046-51. PMID:16537482 | PMCID:PMC1449643

Blundell TL, Sibanda BL, Montalvão RW, Brewerton S, Chelliah V, Worth CL, Harmer NJ, Davies O, Burke D. Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery. Philos Trans R Soc Lond B Biol Sci. 2006 Mar 29;361(1467):413-23. Review. PMID:16524830 | PMCID:PMC1609333

Furnham N, Blundell TL, DePristo MA, Terwilliger TC. Is one solution good enough? Nat Struct Mol Biol. 2006 Mar;13(3):184-5; discussion 185. No abstract available. PMID:16518382

Chelliah V, Blundell TL, Fernández-Recio J. Efficient restraints for protein-protein docking by comparison of observed amino acid substitution patterns with those predicted from local environment. J Mol Biol. 2006 Apr 14;357(5):1669-82. PMID:16488431

de Bakker PI, Furnham N, Blundell TL, DePristo MA. Conformer generation under restraints. Curr Opin Struct Biol. 2006 Apr;16(2):160-5. Review. PMID:16483766

Kerbarh O, Chirgadze DY, Blundell TL, Abell C. Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate. J Mol Biol. 2006 Mar 24;357(2):524-34. PMID:16434053

Doré AS, Furnham N, Davies OR, Sibanda BL, Chirgadze DY, Jackson SP, Pellegrini L, Blundell TL. Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode. DNA Repair (Amst). 2006 Mar 7;5(3):362-8. PMID:16388993

Miguel RN, Chen S, Nikfarjam L, Kominami S, Carpenter B, Dal Pra C, Betterle C, Zanchetta R, Nakamatsu T, Powell M, Hewer R, Blundell TL, Smith BR, Furmaniak J. Analysis of the interaction between human steroid 21-hydroxylase and various monoclonal antibodies using comparative structural modelling. Eur J Endocrinol. 2005 Dec;153(6):949-61. PMID:16322402

Carafoli F, Chirgadze DY, Blundell TL, Gherardi E. Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating protein. FEBS J. 2005 Nov;272(22):5799-807. PMID:16279944

Harmer NJ, Robinson CJ, Adam LE, Ilag LL, Robinson CV, Gallagher JT, Blundell TL. Multimers of the fibroblast growth factor (FGF)-FGF receptor-saccharide complex are formed on long oligomers of heparin. Biochem J. 2006 Feb 1;393(Pt 3):741-8. PMID:16223363 | PMCID:PMC1360727

Robinson CJ, Harmer NJ, Goodger SJ, Blundell TL, Gallagher JT. Cooperative dimerization of fibroblast growth factor 1 (FGF1) upon a single heparin saccharide may drive the formation of 2:2:1 FGF1.FGFR2c.heparin ternary complexes. J Biol Chem. 2005 Dec 23;280(51):42274-82. PMID:16219767

Chelliah V, Blundell TL. Quantifying structural and functional restraints on amino acid substitutions in evolution of proteins. Biochemistry (Mosc). 2005 Aug;70(8):835-40. PMID:16212538

Chelliah V, Blundell T, Mizuguchi K. Functional restraints on the patterns of amino acid substitutions: application to sequence-structure homology recognition. Proteins. 2005 Dec 1;61(4):722-31. PMID:16193489

Miguel RN, Sanders J, Blundell TL, Smith BR, Furmaniak J. Comparative modeling of the thyrotropin receptor. Thyroid. 2005 Jul;15(7):746-7. No abstract available. PMID:16178067

Depristo MA, de Bakker PI, Johnson RJ, Blundell TL. Crystallographic refinement by knowledge-based exploration of complex energy landscapes. Structure. 2005 Sep;13(9):1311-9. PMID:16154088

Sanders J, Allen F, Jeffreys J, Bolton J, Richards T, Depraetere H, Nakatake N, Evans M, Kiddie A, Premawardhana LD, Chirgadze DY, Miguel RN, Blundell TL, Furmaniak J, Smith BR. Characteristics of a monoclonal antibody to the thyrotropin receptor that acts as a powerful thyroid-stimulating autoantibody antagonist. Thyroid. 2005 Jul;15(7):672-82. PMID:16053383

Montalvão RW, Smith RE, Lovell SC, Blundell TL. CHORAL: a differential geometry approach to the prediction of the cores of protein structures. Bioinformatics. 2005 Oct 1;21(19):3719-25. PMID:16046494

Coxon KM, Chakauya E, Ottenhof HH, Whitney HM, Blundell TL, Abell C, Smith AG. Pantothenate biosynthesis in higher plants. Biochem Soc Trans. 2005 Aug;33(Pt 4):743-6. Review. PMID:16042590

Bolanos-Garcia VM, Beaufils S, Renault A, Grossmann JG, Brewerton S, Lee M, Venkitaraman A, Blundell TL. The conserved N-terminal region of the mitotic checkpoint protein BUBR1: a putative TPR motif of high surface activity. Biophys J. 2005 Oct;89(4):2640-9. PMID:16040755 | PMCID:PMC1366764

Ehebauer MT, Chirgadze DY, Hayward P, Martinez Arias A, Blundell TL. High-resolution crystal structure of the human Notch 1 ankyrin domain. Biochem J. 2005 Nov 15;392(Pt 1):13-20. PMID:16011479 | PMCID:PMC1317659

Aurikko JP, Ruotolo BT, Grossmann JG, Moncrieffe MC, Stephens E, Leppänen VM, Robinson CV, Saarma M, Bradshaw RA, Blundell TL. Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75NTR. J Biol Chem. 2005 Sep 30;280(39):33453-60. PMID:16009712 | PMCID:PMC1352310

Congreve M, Murray CW, Blundell TL. Structural biology and drug discovery. Drug Discov Today. 2005 Jul 1;10(13):895-907. Review. PMID:15993809

Lobley CM, Ciulli A, Whitney HM, Williams G, Smith AG, Abell C, Blundell TL. The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound. Biochemistry. 2005 Jun 28;44(25):8930-9. PMID:15966718

Gore SP, Burke DF, Blundell TL. PROVAT: a tool for Voronoi tessellation analysis of protein structures and complexes. Bioinformatics. 2005 Aug 1;21(15):3316-7. PMID:15932902

Blundell TL. Advances in the uses of synchrotron X-ray and proton beams in structural biology. Prog Biophys Mol Biol. 2005 Oct;89(2):121-3. No abstract available. PMID:15910914

Adams N, Bigmore HR, Blundell TL, Boyd CL, Dubberley SR, Sealey AJ, Cowley AR, Skinner ME, Mountford P. New titanium imido synthons: syntheses and supramolecular structures. Inorg Chem. 2005 Apr 18;44(8):2882-94. PMID:15819576

Messenger NJ, Kabitschke C, Andrews R, Grimmer D, Núñez Miguel R, Blundell TL, Smith JC, Wardle FC. Functional specificity of the Xenopus T-domain protein Brachyury is conferred by its ability to interact with Smad1. Dev Cell. 2005 Apr;8(4):599-610. PMID:15809041

Harmer NJ, Sivak JM, Amaya E, Blundell TL. 1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family. FEBS Lett. 2005 Feb 14;579(5):1161-6. PMID:15710406

Cubellis MV, Caillez F, Blundell TL, Lovell SC. Properties of polyproline II, a secondary structure element implicated in protein-protein interactions. Proteins. 2005 Mar 1;58(4):880-92. PMID:15657931 Blundell TL. The developing art of protein crystallisation: new advances from improved knowledge automation and miniaturisation. Prog Biophys Mol Biol. 2005 Jul;88(3):283-4. No abstract available. PMID:15652245

Núñez Miguel R, Sanders J, Jeffreys J, Depraetere H, Evans M, Richards T, Blundell TL, Rees Smith B, Furmaniak J. Analysis of the thyrotropin receptor-thyrotropin interaction by comparative modeling. Thyroid. 2004 Dec;14(12):991-1011. PMID:15650352

Blundell TL. New strategies for structure-guided design of AIDS antivirals. Prog Biophys Mol Biol. 2005 Jun;88(2):191-2. No abstract available. PMID:15572154

Bertrand L, Sayed MF, Pei XY, Parisini E, Dhanaraj V, Bolanos-Garcia VM, Allende JE, Blundell TL. Structure of the regulatory subunit of CK2 in the presence of a p21WAF1 peptide demonstrates flexibility of the acidic loop. Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1698-704. PMID:15388915

Chelliah V, Chen L, Blundell TL, Lovell SC. Distinguishing structural and functional restraints in evolution in order to identify interaction sites. J Mol Biol. 2004 Oct 1;342(5):1487-504. PMID:15364576

Blundell TL, Patel S. High-throughput X-ray crystallography for drug discovery. Curr Opin Pharmacol. 2004 Oct;4(5):490-6. Review. PMID:15351354

Sanders J, Jeffreys J, Depraetere H, Evans M, Richards T, Kiddie A, Brereton K, Premawardhana LD, Chirgadze DY, Núñez Miguel R, Blundell TL, Furmaniak J, Rees Smith B. Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: sequence structure and function. Thyroid. 2004 Aug;14(8):560-70. PMID:15320966

Harmer NJ, Ilag LL, Mulloy B, Pellegrini L, Robinson CV, Blundell TL. Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex. J Mol Biol. 2004 Jun 11;339(4):821-34. PMID:15165853

DePristo MA, de Bakker PI, Blundell TL. Heterogeneity and inaccuracy in protein structures solved by X-ray crystallography. Structure. 2004 May;12(5):831-8. PMID:15130475

González B, Pajares MA, Martínez-Ripoll M, Blundell TL, Sanz-Aparicio J. Crystal structure of rat liver betaine homocysteine s-methyltransferase reveals new oligomerization features and conformational changes upon substrate binding. J Mol Biol. 2004 May 7;338(4):771-82. PMID:15099744

Badasso MO, Dhanaraj V, Wood SP, Cooper JB, Blundell TL. Crystallization and X-ray analysis of the Y75N mutant of Mucor pusillus pepsin complexed with inhibitor. Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):770-2. PMID:15039581

Shetty RP, De Bakker PI, DePristo MA, Blundell TL. Advantages of fine-grained side chain conformer libraries. Protein Eng. 2003 Dec;16(12):963-9. PMID:14983076

Brewerton SC, Doré AS, Drake AC, Leuther KK, Blundell TL. Structural analysis of DNA-PKcs: modelling of the repeat units and insights into the detailed molecular architecture. J Struct Biol. 2004 Mar;145(3):295-306. PMID:14960380

Harmer NJ, Pellegrini L, Chirgadze D, Fernandez-Recio J, Blundell TL. The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. Biochemistry. 2004 Jan 27;43(3):629-40. PMID:14730967

Doré AS, Drake AC, Brewerton SC, Blundell TL. Identification of DNA-PK in the arthropods. Evidence for the ancient ancestry of vertebrate non-homologous end-joining. DNA Repair (Amst). 2004 Jan 5;3(1):33-41. PMID:14697757

Ottenhof HH, Ashurst JL, Whitney HM, Saldanha SA, Schmitzberger F, Gweon HS, Blundell TL, Abell C, Smith AG. Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. Plant J. 2004 Jan;37(1):61-72. PMID:14675432

Schmitzberger F, Kilkenny ML, Lobley CM, Webb ME, Vinkovic M, Matak-Vinkovic D, Witty M, Chirgadze DY, Smith AG, Abell C, Blundell TL. Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase. EMBO J. 2003 Dec 1;22(23):6193-204. PMID:14633979 | PMCID:PMC291833

Yu DS, Sonoda E, Takeda S, Huang CL, Pellegrini L, Blundell TL, Venkitaraman AR. Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2. Mol Cell. 2003 Oct;12(4):1029-41. PMID:14580352

Gherardi E, Youles ME, Miguel RN, Blundell TL, Iamele L, Gough J, Bandyopadhyay A, Hartmann G, Butler PJ. Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12039-44. PMID:14528000 | PMCID:PMC218709

Owen D, Lowe PN, Nietlispach D, Brosnan CE, Chirgadze DY, Parker PJ, Blundell TL, Mott HR. Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1). J Biol Chem. 2003 Dec 12;278(50):50578-87. PMID:14514689

Vinayagam A, Shi J, Pugalenthi G, Meenakshi B, Blundell TL, Sowdhamini R. DDBASE2.0: updated domain database with improved identification of structural domains. Bioinformatics. 2003 Sep 22;19(14):1760-4. PMID:14512346

Lo T, Pellegrini L, Venkitaraman AR, Blundell TL. Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer. DNA Repair (Amst). 2003 Sep 18;2(9):1015-28. PMID:12967658

Miguel RN, Sanders J, Jeffreys J, Depraetere H, Blundell T, Furmaniak J, Rees Smith B. Thyrotropin receptor cleavage domain and tissue inhibitor of metalloproteinase-2. Thyroid. 2003 Jul;13(7):665-6. No abstract available. PMID:12964975

Shin DS, Pellegrini L, Daniels DS, Yelent B, Craig L, Bates D, Yu DS, Shivji MK, Hitomi C, Arvai AS, Volkmann N, Tsuruta H, Blundell TL, Venkitaraman AR, Tainer JA. Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2. EMBO J. 2003 Sep 1;22(17):4566-76. PMID:12941707 | PMCID:PMC202371

DePristo MA, De Bakker PI, Shetty RP, Blundell TL. Discrete restraint-based protein modeling and the Calpha-trace problem. Protein Sci. 2003 Sep;12(9):2032-46. PMID:12931001 | PMCID:PMC2323999

von Delft F, Inoue T, Saldanha SA, Ottenhof HH, Schmitzberger F, Birch LM, Dhanaraj V, Witty M, Smith AG, Blundell TL, Abell C. Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites. Structure. 2003 Aug;11(8):985-96. PMID:12906829

Schmitzberger F, Smith AG, Abell C, Blundell TL. Comparative analysis of the Escherichia coli ketopantoate hydroxymethyltransferase crystal structure confirms that it is a member of the (betaalpha)8 phosphoenolpyruvate/pyruvate superfamily. J Bacteriol. 2003 Jul;185(14):4163-71. PMID:12837791 | PMCID:PMC164873

Lobley CM, Schmitzberger F, Kilkenny ML, Whitney H, Ottenhof HH, Chakauya E, Webb ME, Birch LM, Tuck KL, Abell C, Smith AG, Blundell TL. Structural insights into the evolution of the pantothenate-biosynthesis pathway. Biochem Soc Trans. 2003 Jun;31(Pt 3):563-71. PMID:12773157

Evans PC, Smith TS, Lai MJ, Williams MG, Burke DF, Heyninck K, Kreike MM, Beyaert R, Blundell TL, Kilshaw PJ. A novel type of deubiquitinating enzyme. J Biol Chem. 2003 Jun 20;278(25):23180-6. PMID:12682062

Harmer NJ, Chirgadze D, Hyun Kim K, Pellegrini L, Blundell TL. The structural biology of growth factor receptor activation. Biophys Chem. 2003;100(1-3):545-53. PMID:12646390

DePristo MA, de Bakker PI, Lovell SC, Blundell TL. Ab initio construction of polypeptide fragments: efficient generation of accurate, representative ensembles. Proteins. 2003 Apr 1;51(1):41-55. PMID:12596262

de Bakker PI, DePristo MA, Burke DF, Blundell TL. Ab initio construction of polypeptide fragments: Accuracy of loop decoy discrimination by an all-atom statistical potential and the AMBER force field with the Generalized Born solvation model. Proteins. 2003 Apr 1;51(1):21-40. PMID:12596261

Pellegrini L, Yu DS, Lo T, Anand S, Lee M, Blundell TL, Venkitaraman AR. Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. Nature. 2002 Nov 21;420(6913):287-93. PMID:12442171

González B, Pajares MA, Too HP, Garrido F, Blundell TL, Sanz-Aparicio J. Crystallization and preliminary X-ray study of recombinant betaine-homocysteine S-methyltransferase from rat liver. Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1507-10. PMID:12198317

Patel S, Martínez-Ripoll M, Blundell TL, Albert A. Structural enzymology of Li(+)-sensitive/Mg(2+)-dependent phosphatases. J Mol Biol. 2002 Jul 26;320(5):1087-94. PMID:12126627

Blundell TL, Jhoti H, Abell C. High-throughput crystallography for lead discovery in drug design. Nat Rev Drug Discov. 2002 Jan;1(1):45-54. Review. PMID:12119609

Watanabe K, Chirgadze DY, Lietha D, de Jonge H, Blundell TL, Gherardi E. A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swapping. J Mol Biol. 2002 May 31;319(2):283-8. PMID:12051906

Williams MG, Shirai H, Shi J, Nagendra HG, Mueller J, Mizuguchi K, Miguel RN, Lovell SC, Innis CA, Deane CM, Chen L, Campillo N, Burke DF, Blundell TL, de Bakker PI. Sequence-structure homology recognition by iterative alignment refinement and comparative modeling. Proteins. 2001;Suppl 5:92-7. PMID:11835486

Pomés A, Chapman MD, Vailes LD, Blundell TL, Dhanaraj V. Cockroach allergen Bla g 2: structure, function, and implications for allergic sensitization. Am J Respir Crit Care Med. 2002 Feb 1;165(3):391-7. PMID:11818327

Patel S, Yenush L, Rodríguez PL, Serrano R, Blundell TL. Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy. J Mol Biol. 2002 Jan 25;315(4):677-85. PMID:11812139

Matak-Vinković D, Vinković M, Saldanha SA, Ashurst JL, von Delft F, Inoue T, Miguel RN, Smith AG, Blundell TL, Abell C. Crystal structure of Escherichia coli ketopantoate reductase at 1.7 A resolution and insight into the enzyme mechanism. Biochemistry. 2001 Dec 4;40(48):14493-500. PMID:11724562

Sibanda BL, Critchlow SE, Begun J, Pei XY, Jackson SP, Blundell TL, Pellegrini L. Crystal structure of an Xrcc4-DNA ligase IV complex. Nat Struct Biol. 2001 Dec;8(12):1015-9. PMID:11702069

Lietha D, Chirgadze DY, Mulloy B, Blundell TL, Gherardi E. Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor. EMBO J. 2001 Oct 15;20(20):5543-55. PMID:11597998 | PMCID:PMC125671

de Bakker PI, Bateman A, Burke DF, Miguel RN, Mizuguchi K, Shi J, Shirai H, Blundell TL. HOMSTRAD: adding sequence information to structure-based alignments of homologous protein families. Bioinformatics. 2001 Aug;17(8):748-9. PMID:11524380

Shirai H, Blundell TL, Mizuguchi K. A novel superfamily of enzymes that catalyze the modification of guanidino groups. Trends Biochem Sci. 2001 Aug;26(8):465-8. PMID:11504612

Nagendra HG, Harrington AE, Harmer NJ, Pellegrini L, Blundell TL, Burke DF. Sequence analyses and comparative modeling of fly and worm fibroblast growth factor receptors indicate that the determinants for FGF and heparin binding are retained in evolution. FEBS Lett. 2001 Jul 13;501(1):51-8. PMID:11457455

Shi J, Blundell TL, Mizuguchi K. FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties. J Mol Biol. 2001 Jun 29;310(1):243-57. PMID:11419950

Deane CM, Kaas Q, Blundell TL. SCORE: predicting the core of protein models. Bioinformatics. 2001 Jun;17(6):541-50. PMID:11395432

von Delft F, Lewendon A, Dhanaraj V, Blundell TL, Abell C, Smith AG. The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily. Structure. 2001 May 9;9(5):439-50. PMID:11377204

Mendes J, Nagarajaram HA, Soares CM, Blundell TL, Carrondo MA. Incorporating knowledge-based biases into an energy-based side-chain modeling method: application to comparative modeling of protein structure. Biopolymers. 2001 Aug;59(2):72-86. PMID:11373721

Deane CM, Blundell TL. CODA: a combined algorithm for predicting the structurally variable regions of protein models. Protein Sci. 2001 Mar;10(3):599-612. PMID:11344328 | PMCID:PMC2374131

Innis CA, Shi J, Blundell TL. Evolutionary trace analysis of TGF-beta and related growth factors: implications for site-directed mutagenesis. Protein Eng. 2000 Dec;13(12):839-47. PMID:11239083

Blundell TL, Burke DF, Chirgadze D, Dhanaraj V, Hyvönen M, Innis CA, Parisini E, Pellegrini L, Sayed M, Sibanda BL. Protein-protein interactions in receptor activation and intracellular signalling. Biol Chem. 2000 Sep-Oct;381(9-10):955-9. Review. PMID:11076027

Pellegrini L, Burke DF, von Delft F, Mulloy B, Blundell TL. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. Nature. 2000 Oct 26;407(6807):1029-34. PMID:11069186

Blundell TL, Mizuguchi K. Structural genomics: an overview. Prog Biophys Mol Biol. 2000;73(5):289-95. Review. No abstract available. PMID:11063776

Burke DF, Deane CM, Blundell TL. Browsing the SLoop database of structurally classified loops connecting elements of protein secondary structure. Bioinformatics. 2000 Jun;16(6):513-9. PMID:10980148

Badasso MO, Read JA, Dhanaraj V, Cooper JB, Wood SP, Blundell TL, Dreyer T, Winther J. Purification, co-crystallization and preliminary X--ray analysis of the natural aspartic proteinase inhibitor IA3 complexed with saccharopepsin from Saccharomyces cerevisiae. Acta Crystallogr D Biol Crystallogr. 2000 Jul;56(Pt 7):915-7. PMID:10930843

Marino-Buslje C, Martin-Martinez M, Mizuguchi K, Siddle K, Blundell TL. The insulin receptor: from protein sequence to structure. Biochem Soc Trans. 1999 Aug;27(4):715-26. Review. PMID:10917671

Deane CM, Blundell TL. A novel exhaustive search algorithm for predicting the conformation of polypeptide segments in proteins. Proteins. 2000 Jul 1;40(1):135-44. PMID:10813838

Albert A, Yenush L, Gil-Mascarell MR, Rodriguez PL, Patel S, Martínez-Ripoll M, Blundell TL, Serrano R. X-ray structure of yeast Hal2p, a major target of lithium and sodium toxicity, and identification of framework interactions determining cation sensitivity. J Mol Biol. 2000 Jan 28;295(4):927-38. PMID:10656801

Nagarajaram HA, Reddy BV, Blundell TL. Analysis and prediction of inter-strand packing distances between beta-sheets of globular proteins. Protein Eng. 1999 Dec;12(12):1055-62. PMID:10611399

Mizuguchi K, Dhanaraj V, Blundell TL, Murzin AG. N-ethylmaleimide-sensitive fusion protein (NSF) and CDC48 confirmed as members of the double-psi beta-barrel aspartate decarboxylase/formate dehydrogenase family. Structure. 1999 Sep 15;7(9):R215-6. No abstract available. PMID:10610264

Deane CM, Allen FH, Taylor R, Blundell TL. Carbonyl-carbonyl interactions stabilize the partially allowed Ramachandran conformations of asparagine and aspartic acid. Protein Eng. 1999 Dec;12(12):1025-8. PMID:10611393

Burke DF, Deane CM, Nagarajaram HA, Campillo N, Martin-Martinez M, Mendes J, Molina F, Perry J, Reddy BV, Soares CM, Steward RE, Williams M, Carrondo MA, Blundell TL, Mizuguchi K. An iterative structure-assisted approach to sequence alignment and comparative modeling. Proteins. 1999;Suppl 3:55-60. PMID:10526352

Pavlovsky AG, Williams MG, Ye QZ, Ortwine DF, Purchase CF 2nd, White AD, Dhanaraj V, Roth BD, Johnson LL, Hupe D, Humblet C, Blundell TL. X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity. Protein Sci. 1999 Jul;8(7):1455-62. PMID:10422833 | PMCID:PMC2144373

Walker AR, Davison PA, Bolognesi-Winfield AC, James CM, Srinivasan N, Blundell TL, Esch JJ, Marks MD, Gray JC. The TRANSPARENT TESTA GLABRA1 locus, which regulates trichome differentiation and anthocyanin biosynthesis in Arabidopsis, encodes a WD40 repeat protein. Plant Cell. 1999 Jul;11(7):1337-50. PMID:10402433 | PMCID:PMC144274

Castillo RM, Mizuguchi K, Dhanaraj V, Albert A, Blundell TL, Murzin AG. A six-stranded double-psi beta barrel is shared by several protein superfamilies. Structure. 1999 Feb 15;7(2):227-36. PMID:10368289

Arias CA, Martín-Martinez M, Blundell TL, Arthur M, Courvalin P, Reynolds PE. Characterization and modelling of VanT: a novel, membrane-bound, serine racemase from vancomycin-resistant Enterococcus gallinarum BM4174. Mol Microbiol. 1999 Mar;31(6):1653-64. PMID:10209740

Srinivasan N, Antonelli M, Jacob G, Korn I, Romero F, Jedlicki A, Dhanaraj V, Sayed MF, Blundell TL, Allende CC, Allende JE. Structural interpretation of site-directed mutagenesis and specificity of the catalytic subunit of protein kinase CK2 using comparative modelling. Protein Eng. 1999 Feb;12(2):119-27. PMID:10195283

Korn I, Gutkind S, Srinivasan N, Blundell TL, Allende CC, Allende JE. Interactions of protein kinase CK2 subunits. Mol Cell Biochem. 1999 Jan;191(1-2):75-83. PMID:10094395

Reddy BV, Nagarajaram HA, Blundell TL. Analysis of interactive packing of secondary structural elements in alpha/beta units in proteins. Protein Sci. 1999 Mar;8(3):573-86. PMID:10091660 | PMCID:PMC2144285

Sowdhamini R, Burke DF, Deane C, Huang JF, Mizuguchi K, Nagarajaram HA, Overington JP, Srinivasan N, Steward RE, Blundell TL. Protein three-dimensional structural databases: domains, structurally aligned homologues and superfamilies. Acta Crystallogr D Biol Crystallogr. 1998 Nov 1;54(Pt 6 Pt 1):1168-77. PMID:10089493

Islam SA, Carvin D, Sternberg MJ, Blundell TL. HAD, a data bank of heavy-atom binding sites in protein crystals: a resource for use in multiple isomorphous replacement and anomalous scattering. Acta Crystallogr D Biol Crystallogr. 1998 Nov 1;54(Pt 6 Pt 1):1199-206. PMID:10089497

Chirgadze DY, Hepple JP, Zhou H, Byrd RA, Blundell TL, Gherardi E. Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding. Nat Struct Biol. 1999 Jan;6(1):72-9. PMID:9886295

Marino-Buslje C, Mizuguchi K, Siddle K, Blundell TL. A third fibronectin type III domain in the extracellular region of the insulin receptor family. FEBS Lett. 1998 Dec 18;441(2):331-6. PMID:9883910

Groves MR, Dhanaraj V, Badasso M, Nugent P, Pitts JE, Hoover DJ, Blundell TL. A 2.3 A resolution structure of chymosin complexed with a reduced bond inhibitor shows that the active site beta-hairpin flap is rearranged when compared with the native crystal structure. Protein Eng. 1998 Oct;11(10):833-40. PMID:9862200

Rodionov MA, Blundell TL. Sequence and structure conservation in a protein core. Proteins. 1998 Nov 15;33(3):358-66. PMID:9829695

Mizuguchi K, Deane CM, Blundell TL, Overington JP. HOMSTRAD: a database of protein structure alignments for homologous families. Protein Sci. 1998 Nov;7(11):2469-71. PMID:9828015 | PMCID:PMC2143859

Pellegrini L, Commander P, Mulloy B, Martin-Martinez M, Blundell TL, Burke DF. The role of heparin in the complex formation between fibroblast growth factor 2 and its high affinity receptor: comparative modelling and biochemical studies. Biochem Soc Trans. 1998 Aug;26(3):545-9. No abstract available. PMID:9765911

Sowdhamini R, Burke DF, Huang JF, Mizuguchi K, Nagarajaram HA, Srinivasan N, Steward RE, Blundell TL. CAMPASS: a database of structurally aligned protein superfamilies. Structure. 1998 Sep 15;6(9):1087-94. Review. No abstract available. PMID:9753697

Brotherton DH, Dhanaraj V, Wick S, Brizuela L, Domaille PJ, Volyanik E, Xu X, Parisini E, Smith BO, Archer SJ, Serrano M, Brenner SL, Blundell TL, Laue ED. Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d. Nature. 1998 Sep 17;395(6699):244-50. Erratum in: Nature 1998 Nov 26;396(6709):390. PMID:9751051

Mizuguchi K, Deane CM, Blundell TL, Johnson MS, Overington JP. JOY: protein sequence-structure representation and analysis. Bioinformatics. 1998;14(7):617-23. PMID:9730927

Mizuguchi K, Parker JS, Blundell TL, Gay NJ. Getting knotted: a model for the structure and activation of Spätzle. Trends Biochem Sci. 1998 Jul;23(7):239-42. Review. Erratum in: Trends Biochem Sci 1998 Sep;23(9):361. PMID:9697410

Chirgadze DY, Hepple J, Byrd RA, Sowdhamini R, Blundell TL, Gherardi E. Insights into the structure of hepatocyte growth factor/scatter factor (HGF/SF) and implications for receptor activation. FEBS Lett. 1998 Jun 23;430(1-2):126-9. Review. PMID:9678607

Blundell TL. Leaving the structured world of Oxford. Nat Struct Biol. 1998 Jul;5(7):533. No abstract available. PMID:9665164

Snook CF, Woolley GA, Oliva G, Pattabhi V, Wood SF, Blundell TL, Wallace BA. The structure and function of antiamoebin I, a proline-rich membrane-active polypeptide. Structure. 1998 Jun 15;6(6):783-92. PMID:9655831

Blundell TL, Guruprasad K, Albert A, Williams M, Sibanda BL, Dhanaraj V. The aspartic proteinases. An historical overview. Adv Exp Med Biol. 1998;436:1-13. No abstract available. PMID:9561193

Albert A, Blundell TL, Dhanaraj V, Donate LE, Groves M, Guruprasad K, Nugent PG, Orprayoon P, Pitts JE, Rufino S, Srinivasan N, Williams M, Wilsher J. Protein engineering aspartic proteinases. Site-directed mutagenesis, biochemical characterisation, and X-ray analysis of chymosins with substituted single amino acid substitutions and loop replacements. Adv Exp Med Biol. 1998;436:169-77. Review. No abstract available. PMID:9561215

Albert A, Dhanaraj V, Genschel U, Khan G, Ramjee MK, Pulido R, Sibanda BL, von Delft F, Witty M, Blundell TL, Smith AG, Abell C. Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing. Nat Struct Biol. 1998 Apr;5(4):289-93. PMID:9546220

Olsen V, Guruprasad K, Cawley NX, Chen HC, Blundell TL, Loh YP. Cleavage efficiency of the novel aspartic protease yapsin 1 (Yap3p) enhanced for substrates with arginine residues flanking the P1 site: correlation with electronegative active-site pockets predicted by molecular modeling. Biochemistry. 1998 Mar 3;37(9):2768-77. PMID:9485427

Burke D, Wilkes D, Blundell TL, Malcolm S. Fibroblast growth factor receptors: lessons from the genes. Trends Biochem Sci. 1998 Feb;23(2):59-62. Review. PMID:9538690

Williams MG, Wilsher J, Nugent P, Mills A, Dhanaraj V, Fabry M, Sedlácek J, Uusitalo JM, Penttila ME, Pitts JE, Blundell TL. Mutagenesis, biochemical characterization and X-ray structural analysis of point mutants of bovine chymosin. Protein Eng. 1997 Sep;10(9):991-7. PMID:9464563

Bax B, Blundell TL, Murray-Rust J, McDonald NQ. Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins. Structure. 1997 Oct 15;5(10):1275-85. PMID:9351801

Aguilar CF, Cronin NB, Badasso M, Dreyer T, Newman MP, Cooper JB, Hoover DJ, Wood SP, Johnson MS, Blundell TL. The three-dimensional structure at 2.4 A resolution of glycosylated proteinase A from the lysosome-like vacuole of Saccharomyces cerevisiae. J Mol Biol. 1997 Apr 11;267(4):899-915. PMID:9135120

Rufino SD, Donate LE, Canard LH, Blundell TL. Predicting the conformational class of short and medium size loops connecting regular secondary structures: application to comparative modelling. J Mol Biol. 1997 Mar 28;267(2):352-67. PMID:9096231

Topham CM, Srinivasan N, Blundell TL. Prediction of the stability of protein mutants based on structural environment-dependent amino acid substitution and propensity tables. Protein Eng. 1997 Jan;10(1):7-21. PMID:9051729

Blundell TL, Srinivasan N. Symmetry, stability, and dynamics of multidomain and multicomponent protein systems. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14243-8. Review. PMID:8962033 | PMCID:PMC34468

Donate LE, Rufino SD, Canard LH, Blundell TL. Conformational analysis and clustering of short and medium size loops connecting regular secondary structures: a database for modeling and prediction. Protein Sci. 1996 Dec;5(12):2600-16. PMID:8976569 | PMCID:PMC2143328

Blundell TL. Structure-based drug design. Nature. 1996 Nov 7;384(6604 Suppl):23-6. PMID:8895597

Srinivasan N, Bax B, Blundell TL, Parker PJ. Structural aspects of the functional modules in human protein kinase-C alpha deduced from comparative analyses. Proteins. 1996 Oct;26(2):217-35. PMID:8916229

Nugent PG, Albert A, Orprayoon P, Wilsher J, Pitts JE, Blundell TL, Dhanaraj V. Protein engineering loops in aspartic proteinases: site-directed mutagenesis, biochemical characterization and X-ray analysis of chymosin with a replaced loop from rhizopuspepsin. Protein Eng. 1996 Oct;9(10):885-93. PMID:8931128

Guruprasad K, Blundell TL, Xie S, Green J, Szafranska B, Nagel RJ, McDowell K, Baker CB, Roberts RM. Comparative modelling and analysis of amino acid substitutions suggests that the family of pregnancy-associated glycoproteins includes both active and inactive aspartic proteinases. Protein Eng. 1996 Oct;9(10):849-56. PMID:8931124

Zhu ZY, Blundell TL. The use of amino acid patterns of classified helices and strands in secondary structure prediction. J Mol Biol. 1996 Jul 12;260(2):261-76. PMID:8764405

Baker EN, Blundell TL, Vijayan M, Dodson E, Dodson G, Gilliland GL, Sussman JL. Archival journal requirements for data deposition. Biophys J. 1996 Jun;70(6):2994. No abstract available. PMID:8744337 | PMCID:PMC1225279

Louie GV, Brownlie PD, Lambert R, Cooper JB, Blundell TL, Wood SP, Malashkevich VN, Hädener A, Warren MJ, Shoolingin-Jordan PM. The three-dimensional structure of Escherichia coli porphobilinogen deaminase at 1.76-A resolution. Proteins. 1996 May;25(1):48-78. PMID:8727319

Baker EN, Blundell TL, Vijayan M, Dodson E, Gilliland GL, Sussman JL. Deposition of macromolecular data. Acta Crystallogr D Biol Crystallogr. 1996 May 1;52(Pt 3):609. No abstract available. PMID:15299695

Dhanaraj V, Ye QZ, Johnson LL, Hupe DJ, Ortwine DF, Dunbar JB Jr, Rubin JR, Pavlovsky A, Humblet C, Blundell TL. X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily. Structure. 1996 Apr 15;4(4):375-86. PMID:8740360

Dhanaraj V, Ye QZ, Johnson LL, Hupe DJ, Ortwine DF, Dunbar JB Jr, Rubin JR, Pavlovsky A, Humblet C, Blundell TL. Designing inhibitors of the metalloproteinase superfamily: comparative analysis of representative structures. Drug Des Discov. 1996 Apr;13(3-4):3-14. PMID:8874040

Srinivasan V, Waterfield MD, Blundell TL. Comparative analysis of the regions binding beta gamma-subunits in Galpha and PH domains. Biochem Biophys Res Commun. 1996 Mar 27;220(3):697-702. PMID:8607828

Introna M, Alles VV, Castellano M, Picardi G, De Gioia L, Bottazzai B, Peri G, Breviario F, Salmona M, De Gregorio L, Dragani TA, Srinivasan N, Blundell TL, Hamilton TA, Mantovani A. Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites. Blood. 1996 Mar 1;87(5):1862-72. PMID:8634434

Baker EN, Blundell TL, Vijayan M, Dodson E, Dodson G, Gilliland GL, Sussman JL. International Seminar-cum-School on Macromolecular Crystallographic Data at Calcutta, India. Anticancer Drug Des. 1996 Mar;11(2):173-4. No abstract available. PMID:8630188

Baker EN, Blundell TL, Vijayan M, Dodson E, Dodson G, Gilliland GL, Sussman JL. A formal discussion of the archival journal requirements for data deposition. Biochem Biophys Res Commun. 1996 Feb 27;219(3):976-7. No abstract available. PMID:8645289

Baker EN, Blundell TL, Dodson E, Dodson G, Gilliland GL, Sussman JL, Vijayan M. Diffraction data deposition. Structure. 1996 Feb 15;4(2):217. No abstract available. PMID:8805528

Baker EN, Blundell TL, Vijayan M, Dodson E, Dodson G, Gilliland GL, Sussman JL. Archival journal requirements of macromolecular crystallographic data. J Biomol Struct Dyn. 1996 Feb;13(4):583. No abstract available. PMID:8906878

Baker EN, Blundell TL, Vijayan M, Dodson E, Dodson G, Gilliland GI, Sussman JL. Crystallographic data deposition. Nature. 1996 Jan 18;379(6562):202. No abstract available. PMID:8538780

Sowdhamini R, Rufino SD, Blundell TL. A database of globular protein structural domains: clustering of representative family members into similar folds. Fold Des. 1996;1(3):209-20. PMID:9079382

Rufino SD, Donate LE, Canard L, Blundell TL. Analysis, clustering and prediction of the conformation of short and medium size loops connecting regular secondary structures. Pac Symp Biocomput. 1996:570-89. PMID:9390259

Blundell TL. The Leon Golberg Memorial Lecture. Structural molecular biology and drug discovery. Food Chem Toxicol. 1995 Nov;33(11):979-85. Review. No abstract available. PMID:7590546

Blundell TL, Zhu ZY. The alpha-helix as seen from the protein tertiary structure: a 3-D structural classification. Biophys Chem. 1995 Jun-Jul;55(1-2):167-84. PMID:7632876

Guruprasad L, Dhanaraj V, Timm D, Blundell TL, Gout I, Waterfield MD. The crystal structure of the N-terminal SH3 domain of Grb2. J Mol Biol. 1995 May 12;248(4):856-66. PMID:7752246

Sowdhamini R, Blundell TL. An automatic method involving cluster analysis of secondary structures for the identification of domains in proteins. Protein Sci. 1995 Mar;4(3):506-20. PMID:7795532 | PMCID:PMC2143076

McDonald NQ, Murray-Rust J, Blundell TL. The first structure of a receptor tyrosine kinase domain: a further step in understanding the molecular basis of insulin action. Structure. 1995 Jan 15;3(1):1-6. Review. PMID:7743124

Dhanaraj RR, Pitts JE, Nugent P, Orprayoon P, Cooper JB, Blundell TL, Uusitalo J, Penttilä M. Protein engineering of surface loops: preliminary X-ray analysis of the CHY155-165RHI mutant. Adv Exp Med Biol. 1995;362:95-9. No abstract available. PMID:8540386

Aguilar CF, Dhanaraj V, Guruprasad K, Dealwis C, Badasso M, Cooper JB, Wood SP, Blundell TL. Comparisons of the three-dimensional structures, specificities and glycosylation of renins, yeast proteinase A and cathepsin D. Adv Exp Med Biol. 1995;362:155-66. PMID:8540315

Donate LE, Gherardi E, Srinivasan N, Sowdhamini R, Aparicio S, Blundell TL. Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP). Protein Sci. 1994 Dec;3(12):2378-94. PMID:7756992 | PMCID:PMC2142779

Srinivasan N, White HE, Emsley J, Wood SP, Pepys MB, Blundell TL. Comparative analyses of pentraxins: implications for protomer assembly and ligand binding. Structure. 1994 Nov 15;2(11):1017-27. PMID:7881902

Bradshaw RA, Murray-Rust J, Ibáñez CF, McDonald NQ, Lapatto R, Blundell TL. Nerve growth factor: structure/function relationships. Protein Sci. 1994 Nov;3(11):1901-13. PMID:7703837 | PMCID:PMC2142654

Brownlie PD, Lambert R, Louie GV, Jordan PM, Blundell TL, Warren MJ, Cooper JB, Wood SP. The three-dimensional structures of mutants of porphobilinogen deaminase: toward an understanding of the structural basis of acute intermittent porphyria. Protein Sci. 1994 Oct;3(10):1644-50. Review. PMID:7849582 | PMCID:PMC2142616

Guruprasad K, Törmäkangas K, Kervinen J, Blundell TL. Comparative modelling of barley-grain aspartic proteinase: a structural rationale for observed hydrolytic specificity. FEBS Lett. 1994 Sep 26;352(2):131-6. PMID:7925961

May AC, Blundell TL. Automated comparative modelling of protein structures. Curr Opin Biotechnol. 1994 Aug;5(4):355-60. Review. PMID:7765167

May AC, Johnson MS, Rufino SD, Wako H, Zhu ZY, Sowdhamini R, Srinivasan N, Rodionov MA, Blundell TL. The recognition of protein structure and function from sequence: adding value to genome data. Philos Trans R Soc Lond B Biol Sci. 1994 Jun 29;344(1310):373-81. Review. PMID:7800707

Wako H, Blundell TL. Use of amino acid environment-dependent substitution tables and conformational propensities in structure prediction from aligned sequences of homologous proteins. II. Secondary structures. J Mol Biol. 1994 May 20;238(5):693-708. PMID:8182744

Wako H, Blundell TL. Use of amino acid environment-dependent substitution tables and conformational propensities in structure prediction from aligned sequences of homologous proteins. I. Solvent accessibility classes. J Mol Biol. 1994 May 20;238(5):682-92. PMID:8182743

Donnelly D, Overington JP, Blundell TL. The prediction and orientation of alpha-helices from sequence alignments: the combined use of environment-dependent substitution tables, Fourier transform methods and helix capping rules. Protein Eng. 1994 May;7(5):645-53. PMID:8073034

Blundell TL. Problems and solutions in protein engineering--towards rational design. Trends Biotechnol. 1994 May;12(5):145-8. No abstract available. PMID:7764894

Newman RH, Carpenter E, Freemont PS, Blundell TL, Parker PJ. Microcrystals of the beta 1 isoenzyme of protein kinase C: an electron microscopic study. Biochem J. 1994 Mar 1;298 ( Pt 2):391-3. PMID:8135746 | PMCID:PMC1137952

Dealwis CG, Frazao C, Badasso M, Cooper JB, Tickle IJ, Driessen H, Blundell TL, Murakami K, Miyazaki H, Sueiras-Diaz J, et al. X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen. J Mol Biol. 1994 Feb 11;236(1):342-60. PMID:8107115

Rufino SD, Blundell TL. Structure-based identification and clustering of protein families and superfamilies. J Comput Aided Mol Des. 1994 Feb;8(1):5-27. PMID:8035212

Blundell TL. Metalloproteinase superfamilies and drug design. Nat Struct Biol. 1994 Feb;1(2):73-5. No abstract available. PMID:7656018

Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP. Structure of pentameric human serum amyloid P component. Nature. 1994 Jan 27;367(6461):338-45. PMID:8114934

Whittle PJ, Blundell TL. Protein structure--based drug design. Annu Rev Biophys Biomol Struct. 1994;23:349-75. Review. PMID:7919786

Lambert R, Brownlie PD, Woodcock SC, Louie GV, Cooper JC, Warren MJ, Jordan PM, Blundell TL, Wood SP. Structural studies on porphobilinogen deaminase. Ciba Found Symp. 1994;180:97-104; discussion 105-10. PMID:7842864

Johnson MS, Srinivasan N, Sowdhamini R, Blundell TL. Knowledge-based protein modeling. Crit Rev Biochem Mol Biol. 1994;29(1):1-68. Review. PMID:8143488

Donnelly D, Findlay JB, Blundell TL. The evolution and structure of aminergic G protein-coupled receptors. Receptors Channels. 1994;2(1):61-78. PMID:8081733

Sali A, Blundell TL. Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol. 1993 Dec 5;234(3):779-815. PMID:8254673

Murray-Rust J, McDonald NQ, Blundell TL, Hosang M, Oefner C, Winkler F, Bradshaw RA. Topological similarities in TGF-beta 2, PDGF-BB and NGF define a superfamily of polypeptide growth factors. Structure. 1993 Oct 15;1(2):153-9. PMID:8069627

Reddy BV, Blundell TL. Packing of secondary structural elements in proteins. Analysis and prediction of inter-helix distances. J Mol Biol. 1993 Oct 5;233(3):464-79. PMID:8411156

Overington JP, Zhu ZY, Sali A, Johnson MS, Sowdhamini R, Louie GV, Blundell TL. Molecular recognition in protein families: a database of aligned three-dimensional structures of related proteins. Biochem Soc Trans. 1993 Aug;21 ( Pt 3)(3):597-604. No abstract available. PMID:8224474

Badasso M, Wood SP, Aguilar C, Cooper JB, Blundell TL, Dreyer T. Crystallization and preliminary crystallographic characterization of aspartic proteinase-A from baker's yeast and its complexes with inhibitors. J Mol Biol. 1993 Jul 20;232(2):701-3. PMID:8345528

Srinivasan N, Blundell TL. An evaluation of the performance of an automated procedure for comparative modelling of protein tertiary structure. Protein Eng. 1993 Jul;6(5):501-12. PMID:8415577

Johnson MS, Overington JP, Blundell TL. Alignment and searching for common protein folds using a data bank of structural templates. J Mol Biol. 1993 Jun 5;231(3):735-52. PMID:8515448

Blundell TL, Johnson MS. Catching a common fold. Protein Sci. 1993 Jun;2(6):877-83. Review. No abstract available. PMID:8318893 | PMCID:PMC2142408

Newman M, Watson F, Roychowdhury P, Jones H, Badasso M, Cleasby A, Wood SP, Tickle IJ, Blundell TL. X-ray analyses of aspartic proteinases. V. Structure and refinement at 2.0 A resolution of the aspartic proteinase from Mucor pusillus. J Mol Biol. 1993 Mar 5;230(1):260-83. PMID:8450540

Najmudin S, Nalini V, Driessen HP, Slingsby C, Blundell TL, Moss DS, Lindley PF. Structure of the bovine eye lens protein gammaB(gammaII)-crystallin at 1.47 A. Acta Crystallogr D Biol Crystallogr. 1993 Mar 1;49(Pt 2):223-33. PMID:15299528

Aguilar CF, Newman MP, Sanz Aparicio J, Cooper JB, Tickle IJ, Blundell TL. The use of protein homologues in the rotation function. Acta Crystallogr A. 1993 Mar 1;49 ( Pt 2):306-15. PMID:8447986

Scarborough PE, Guruprasad K, Topham C, Richo GR, Conner GE, Blundell TL, Dunn BM. Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling. Protein Sci. 1993 Feb;2(2):264-76. PMID:8443603 | PMCID:PMC2142340

Hoffrén AM, Saloheimo M, Thomas P, Overington JP, Johnson MS, Knowles JK, Blundell TL. Modelling of the lignin peroxidase LIII of Phlebia radiata: use of a sequence template generated from a 3-D structure. Protein Eng. 1993 Feb;6(2):177-82. PMID:8386362

Bradshaw RA, Blundell TL, Lapatto R, McDonald NQ, Murray-Rust J. Nerve growth factor revisited. Trends Biochem Sci. 1993 Feb;18(2):48-52. Review. PMID:8488558

Bailey D, Cooper JB, Veerapandian B, Blundell TL, Atrash B, Jones DM, Szelke M. X-ray-crystallographic studies of complexes of pepstatin A and a statine-containing human renin inhibitor with endothiapepsin. Biochem J. 1993 Jan 15;289 ( Pt 2):363-71. PMID:8424781 | PMCID:PMC1132176

Topham CM, McLeod A, Eisenmenger F, Overington JP, Johnson MS, Blundell TL. Fragment ranking in modelling of protein structure. Conformationally constrained environmental amino acid substitution tables. J Mol Biol. 1993 Jan 5;229(1):194-220. PMID:8421300

Donnelly D, Overington JP, Ruffle SV, Nugent JH, Blundell TL. Modeling alpha-helical transmembrane domains: the calculation and use of substitution tables for lipid-facing residues. Protein Sci. 1993 Jan;2(1):55-70. PMID:8443590 | PMCID:PMC2142307

Panayotou G, Bax B, Gout I, Federwisch M, Wroblowski B, Dhand R, Fry MJ, Blundell TL, Wollmer A, Waterfield MD. Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes. EMBO J. 1992 Dec;11(12):4261-72. PMID:1330535 | PMCID:PMC556998

Ruffle SV, Donnelly D, Blundell TL, Nugent JH. A three-dimensional model of the Photosystem II reaction centre of Pisum sativum. Photosynth Res. 1992 Nov;34(2):287-300. doi: 10.1007/BF00033446. PMID:24408780

Cooper J, Quail W, Frazao C, Foundling SI, Blundell TL, Humblet C, Lunney EA, Lowther WT, Dunn BM. X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors. Biochemistry. 1992 Sep 8;31(35):8142-50. PMID:1525155

Louie GV, Brownlie PD, Lambert R, Cooper JB, Blundell TL, Wood SP, Warren MJ, Woodcock SC, Jordan PM. Structure of porphobilinogen deaminase reveals a flexible multidomain polymerase with a single catalytic site. Nature. 1992 Sep 3;359(6390):33-9. PMID:1522882

Murray-Rust J, McLeod AN, Blundell TL, Wood SP. Structure and evolution of insulins: implications for receptor binding. Bioessays. 1992 May;14(5):325-31. Review. PMID:1322139

Ibáñez CF, Ebendal T, Barbany G, Murray-Rust J, Blundell TL, Persson H. Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product. Cell. 1992 Apr 17;69(2):329-41. PMID:1314703

Jordan PM, Warren MJ, Mgbeje BI, Wood SP, Cooper JB, Louie G, Brownlie P, Lambert R, Blundell TL. Crystallization and preliminary X-ray investigation of Escherichia coli porphobilinogen deaminase. J Mol Biol. 1992 Mar 5;224(1):269-71. PMID:1548705

Veerapandian B, Cooper JB, Sali A, Blundell TL, Rosati RL, Dominy BW, Damon DB, Hoover DJ. Direct observation by X-ray analysis of the tetrahedral "intermediate" of aspartic proteinases. Protein Sci. 1992 Mar;1(3):322-8. PMID:1304340 | PMCID:PMC2142209

Sali A, Veerapandian B, Cooper JB, Moss DS, Hofmann T, Blundell TL. Domain flexibility in aspartic proteinases. Proteins. 1992 Feb;12(2):158-70. PMID:1603805

Overington J, Donnelly D, Johnson MS, Sali A, Blundell TL. Environment-specific amino acid substitution tables: tertiary templates and prediction of protein folds. Protein Sci. 1992 Feb;1(2):216-26. PMID:1304904 | PMCID:PMC2142193

Badasso M, Frazao C, Sibanda BL, Dhanaraj V, DeAlwis C, Cooper JB, Wood SP, Blundell TL, Murakami K, Miyazaki H, et al. Crystallization and preliminary X-ray analysis of complexes of peptide inhibitors with human recombinant and mouse submandibular renins. J Mol Biol. 1992 Jan 20;223(2):447-53. PMID:1738157

Zhu ZY, Sali A, Blundell TL. A variable gap penalty function and feature weights for protein 3-D structure comparisons. Protein Eng. 1992 Jan;5(1):43-51. PMID:1631045

Pitts JE, Dhanaraj V, Dealwis CG, Mantafounis D, Nugent P, Orprayoon P, Cooper JB, Newman M, Blundell TL. Multidisciplinary cycles for protein engineering: site-directed mutagenesis and X-ray structural studies of aspartic proteinases. Scand J Clin Lab Invest Suppl. 1992;210:39-50. Review. PMID:1455178

Lapatto R, Nalini V, Bax B, Driessen H, Lindley PF, Blundell TL, Slingsby C. High resolution structure of an oligomeric eye lens beta-crystallin. Loops, arches, linkers and interfaces in beta B2 dimer compared to a monomeric gamma-crystallin. J Mol Biol. 1991 Dec 20;222(4):1067-83. PMID:1762146

McDonald NQ, Lapatto R, Murray-Rust J, Gunning J, Wlodawer A, Blundell TL. New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. Nature. 1991 Dec 5;354(6352):411-4. PMID:1956407

Newman M, Safro M, Frazao C, Khan G, Zdanov A, Tickle IJ, Blundell TL, Andreeva N. X-ray analyses of aspartic proteinases. IV. Structure and refinement at 2.2 A resolution of bovine chymosin. J Mol Biol. 1991 Oct 20;221(4):1295-309. PMID:1942052

Orprayoon P, Pitts JE, Nugent P, Mantafounis D, Lawler SE, Blundell TL, Uusitalo J, Penttilä M. Protein engineering of the surface loops of chymosin. Biochem Soc Trans. 1991 Aug;19(3):265S. No abstract available. PMID:1783113

McDonald NQ, Blundell TL. Crystallization and characterization of the high molecular weight form of nerve growth factor (7 S NGF). J Mol Biol. 1991 Jun 20;219(4):595-601. PMID:2056528

Lunney EA, Humblet CC, Repine JT, Blundell TL, Cooper JB, Sibanda BL. Molecular modeling of renin inhibitor P2 substituents. Adv Exp Med Biol. 1991;306:391-4. No abstract available. PMID:1812735

Hoover DJ, Veerapandian B, Cooper JB, Damon DB, Dominy BW, Rosati RL, Blundell TL. X-ray analysis of a difluorostatone renin inhibitor bound as the tetrahedral hydrate to the aspartic protease endothiapepsin. Adv Exp Med Biol. 1991;306:269-73. No abstract available. PMID:1812716

Blundell TL. Comparative analysis of protein three-dimensional structures and an approach to the inverse folding problem. Ciba Found Symp. 1991;161:28-36; discussion 37-51. PMID:1814695

Blundell TL, Cooper JB, Sali A, Zhu ZY. Comparisons of the sequences, 3-D structures and mechanisms of pepsin-like and retroviral aspartic proteinases. Adv Exp Med Biol. 1991;306:443-53. No abstract available. PMID:1812741

Veerapandian B, Cooper JB, Sali A, Blundell TL. X-ray analyses of aspartic proteinases. III Three-dimensional structure of endothiapepsin complexed with a transition-state isostere inhibitor of renin at 1.6 A resolution. J Mol Biol. 1990 Dec 20;216(4):1017-29. PMID:2266553

Blundell TL, Lapatto R, Wilderspin AF, Hemmings AM, Hobart PM, Danley DE, Whittle PJ. The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS. Trends Biochem Sci. 1990 Nov;15(11):425-30. Review. PMID:2278102

Bax B, Lapatto R, Nalini V, Driessen H, Lindley PF, Mahadevan D, Blundell TL, Slingsby C. X-ray analysis of beta B2-crystallin and evolution of oligomeric lens proteins. Nature. 1990 Oct 25;347(6295):776-80. PMID:2234050

Overington J, Johnson MS, Sali A, Blundell TL. Tertiary structural constraints on protein evolutionary diversity: templates, key residues and structure prediction. Proc Biol Sci. 1990 Aug 22;241(1301):132-45. PMID:1978340

Cooper JB, Khan G, Taylor G, Tickle IJ, Blundell TL. X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution. J Mol Biol. 1990 Jul 5;214(1):199-222. PMID:2115088

Sali A, Overington JP, Johnson MS, Blundell TL. From comparisons of protein sequences and structures to protein modelling and design. Trends Biochem Sci. 1990 Jun;15(6):235-40. Review. No abstract available. PMID:2200167

Husain J, Blundell TL, Cooper S, Pitts JE, Tickle IJ, Wood SP, Hruby VJ, Buku A, Fischman AJ, Wyssbrod HR, et al. The conformation of deamino-oxytocin: X-ray analysis of the 'dry' and 'wet' forms. Philos Trans R Soc Lond B Biol Sci. 1990 Apr 27;327(1243):625-54. Erratum in: Philos Trans R Soc Lond Biol 1990 Jun 30;328(1251):239. PMID:1972289

Sali A, Blundell TL. Definition of general topological equivalence in protein structures. A procedure involving comparison of properties and relationships through simulated annealing and dynamic programming. J Mol Biol. 1990 Mar 20;212(2):403-28. PMID:2181150

Blundell TL, Jenkins JA, Sewell BT, Pearl LH, Cooper JB, Tickle IJ, Veerapandian B, Wood SP. X-ray analyses of aspartic proteinases. The three-dimensional structure at 2.1 A resolution of endothiapepsin. J Mol Biol. 1990 Feb 20;211(4):919-41. PMID:2179568

Waterfield MD, Greenfield C, Hiles I, Federwisch M, Wollmer A, Blundell TL, McDonald N. The use of optical techniques to detect conformational changes associated with the interaction of epidermal growth factor and its receptor. Adv Second Messenger Phosphoprotein Res. 1990;24:301-6. No abstract available. PMID:2119642

Topham CM, Thomas P, Overington JP, Johnson MS, Eisenmenger F, Blundell TL. An assessment of COMPOSER: a rule-based approach to modelling protein structure. Biochem Soc Symp. 1990;57:1-9. PMID:2099735

McDonald NQ, Lapatto R, Murray-Rust J, Blundell TL. X-ray crystallographic studies on murine nerve growth factor. J Cell Sci Suppl. 1990;13:19-30. PMID:2084116

Johnson MS, Sali A, Blundell TL. Phylogenetic relationships from three-dimensional protein structures. Methods Enzymol. 1990;183:670-90. No abstract available. PMID:2156133

Johnson MS, Sutcliffe MJ, Blundell TL. Molecular anatomy: phyletic relationships derived from three-dimensional structures of proteins. J Mol Evol. 1990 Jan;30(1):43-59. PMID:2107323

Greenfield C, Hiles I, Waterfield MD, Federwisch M, Wollmer A, Blundell TL, McDonald N. Epidermal growth factor binding induces a conformational change in the external domain of its receptor. EMBO J. 1989 Dec 20;8(13):4115-23. PMID:2591370 | PMCID:PMC401594

Cooper JB, Foundling SI, Blundell TL, Boger J, Jupp RA, Kay J. X-ray studies of aspartic proteinase-statine inhibitor complexes. Biochemistry. 1989 Oct 17;28(21):8596-603. PMID:2690945

Blundell TL, Elliott G, Gardner SP, Hubbard T, Islam S, Johnson M, Mantafounis D, Murray-Rust P, Overington J, Pitts JE, et al. Protein engineering and design. Philos Trans R Soc Lond B Biol Sci. 1989 Aug 31;324(1224):447-60. Review. PMID:2573083

Sali A, Veerapandian B, Cooper JB, Foundling SI, Hoover DJ, Blundell TL. High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme. EMBO J. 1989 Aug;8(8):2179-88. PMID:2676515 | PMCID:PMC401145

Donnelly D, Johnson MS, Blundell TL, Saunders J. An analysis of the periodicity of conserved residues in sequence alignments of G-protein coupled receptors. Implications for the three-dimensional structure. FEBS Lett. 1989 Jul 17;251(1-2):109-16. PMID:2546817

Sibanda BL, Blundell TL, Thornton JM. Conformation of beta-hairpins in protein structures. A systematic classification with applications to modelling by homology, electron density fitting and protein engineering. J Mol Biol. 1989 Apr 20;206(4):759-77. PMID:2500530

Thornton JM, Singh J, Campbell S, Blundell TL. Protein-protein recognition via side-chain interactions. Biochem Soc Trans. 1988 Dec;16(6):927-30. No abstract available. PMID:3224756

Baker EN, Blundell TL, Cutfield JF, Cutfield SM, Dodson EJ, Dodson GG, Hodgkin DM, Hubbard RE, Isaacs NW, Reynolds CD, et al. The structure of 2Zn pig insulin crystals at 1.5 A resolution. Philos Trans R Soc Lond B Biol Sci. 1988 Jul 6;319(1195):369-456. PMID:2905485

Wood SP, Oliva G, O'Hara BP, White HE, Blundell TL, Perkins SJ, Sardharwalla I, Pepys MB. A pentameric form of human serum amyloid P component. Crystallization, X-ray diffraction and neutron scattering studies. J Mol Biol. 1988 Jul 5;202(1):169-73. PMID:3172210

Slingsby C, Driessen HP, Mahadevan D, Bax B, Blundell TL. Evolutionary and functional relationships between the basic and acidic beta-crystallins. Exp Eye Res. 1988 Mar;46(3):375-403. PMID:3350075

Sergeev YV, Chirgadze YN, Mylvaganam SE, Driessen H, Slingsby C, Blundell TL. Surface interactions of gamma-crystallins in the crystal medium in relation to their association in the eye lens. Proteins. 1988;4(2):137-47. PMID:3227014

Luchin SV, Zinovieva RD, Tomarev SI, Dolgilevich SM, Gause GG Jr, Bax B, Driessen H, Blundell TL. Frog lens beta A1-crystallin: the nucleotide sequence of the cloned cDNA and computer graphics modelling of the three-dimensional structure. Biochim Biophys Acta. 1987 Nov 26;916(2):163-71. PMID:3499937

Safro MG, Andreeva NS, Blundell TL. [The role of peripheral interactions in chymosin specificity]. Mol Biol (Mosk). 1987 Nov-Dec;21(6):1582-9. Russian. PMID:3128729

Sutcliffe MJ, Haneef I, Carney D, Blundell TL. Knowledge based modelling of homologous proteins, Part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures. Protein Eng. 1987 Oct-Nov;1(5):377-84. PMID:3508286

Sutcliffe MJ, Hayes FR, Blundell TL. Knowledge based modelling of homologous proteins, Part II: Rules for the conformations of substituted sidechains. Protein Eng. 1987 Oct-Nov;1(5):385-92. PMID:3508287

Blundell TL, Cooper J, Foundling SI, Jones DM, Atrash B, Szelke M. On the rational design of renin inhibitors: X-ray studies of aspartic proteinases complexed with transition-state analogues. Biochemistry. 1987 Sep 8;26(18):5585-90. Review. No abstract available. PMID:3314991

Cooper JB, Foundling SI, Hemmings A, Watson FE, Sibanda BL, Blundell TL, Jones DM, Hallett A, Atrash B, Szelke M. Inhibitors of aspartic proteinases and their relevance to the design of antihypertensive agents. Biochem Soc Trans. 1987 Aug;15(4):751-4. No abstract available. PMID:3119394

Jhoti H, McLeod AN, Blundell TL, Ishizaki H, Nagasawa H, Suzuki A. Prothoracicotrophic hormone has an insulin-like tertiary structure. FEBS Lett. 1987 Jul 27;219(2):419-25. PMID:3301403

Hubbard TJ, Blundell TL. Comparison of solvent-inaccessible cores of homologous proteins: definitions useful for protein modelling. Protein Eng. 1987 Jun;1(3):159-71. PMID:3507702

Foundling SI, Cooper J, Watson FE, Cleasby A, Pearl LH, Sibanda BL, Hemmings A, Wood SP, Blundell TL, Valler MJ, et al. High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes. Nature. 1987 May 28-Jun 3;327(6120):349-52. PMID:3295561

Sergeev IuV, Chirgadze IuN, Driessen H, Slingsby C, Blundell TL. [The key role of the residue 103 in the surface interactions of gamma-crystallins]. Mol Biol (Mosk). 1987 Mar-Apr;21(2):377-81. Russian. PMID:3600621

Blundell TL, Sibanda BL, Sternberg MJ, Thornton JM. Knowledge-based prediction of protein structures and the design of novel molecules. Nature. 1987 Mar 26-Apr 1;326(6111):347-52. Review. PMID:3550471

Summers LJ, Blundell TL, Gause GG, Tomarev SI. A computer graphics model of frog gamma-crystallin based on the three-dimensional structure of calf gamma-II crystallin. FEBS Lett. 1986 Nov 10;208(1):11-6. PMID:3770205

Bajaj M, Blundell TL, Horuk R, Pitts JE, Wood SP, Gowan LK, Schwabe C, Wollmer A, Gliemann J, Gammeltoft S. Coypu insulin. Primary structure, conformation and biological properties of a hystricomorph rodent insulin. Biochem J. 1986 Sep 1;238(2):345-51. PMID:3541911 | PMCID:PMC1147142

Summers LJ, Slingsby C, Blundell TL, den Dunnen JT, Moormann RJ, Schoenmakers JG. Structural variation in mammalian gamma-crystallins based on computer graphics analyses of human, rat and calf sequences. 1. Core packing and surface properties. Exp Eye Res. 1986 Jul;43(1):77-92. PMID:3732418

Wood SP, Tickle IJ, Treharne AM, Pitts JE, Mascarenhas Y, Li JY, Husain J, Cooper S, Blundell TL, Hruby VJ, et al. Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding. Science. 1986 May 2;232(4750):633-6. PMID:3008332

Griffin JF, Langs DA, Smith GD, Blundell TL, Tickle IJ, Bedarkar S. The crystal structures of [Met5]enkephalin and a third form of [Leu5]enkephalin: observations of a novel pleated beta-sheet. Proc Natl Acad Sci U S A. 1986 May;83(10):3272-6. PMID:3458181 | PMCID:PMC323495

Glover ID, Moss DS, Tickle IJ, Pitts JE, Haneef I, Wood SP, Blundell TL. Anisotropic thermal motion and polypeptide secondary structure studied by X-ray analysis at 0.98A resolution. Adv Biophys. 1985;20:1-12. PMID:3834786

Aulabaugh A, Niemczura WP, Blundell TL, Gibbons WA. A study of the interactions between residues in the C-terminal half of calmodulin by one and two-dimensional NMR methods and computer modelling. Eur J Biochem. 1984 Sep 3;143(2):409-18. PMID:6088236

Travers P, Blundell TL, Sternberg MJ, Bodmer WF. Structural and evolutionary analysis of HLA-D-region products. Nature. 1984 Jul 19-25;310(5974):235-8. PMID:6379465

Glover ID, Barlow DJ, Pitts JE, Wood SP, Tickle IJ, Blundell TL, Tatemoto K, Kimmel JR, Wollmer A, Strassburger W, et al. Conformational studies on the pancreatic polypeptide hormone family. Eur J Biochem. 1984 Jul 16;142(2):379-85. PMID:6745282

Chawdhury SA, Dodson EJ, Dodson GG, Reynolds CD, Tolley SP, Blundell TL, Cleasby A, Pitts JE, Tickle IJ, Wood SP. The crystal structures of three non-pancreatic human insulins. Diabetologia. 1983 Dec;25(6):460-4. PMID:6363174

Bajaj M, Blundell TL, Pitts JE, Wood SP, Tatnell MA, Falkmer S, Emdin SO, Gowan LK, Crow H, Schwabe C, et al. Dogfish insulin. Primary structure, conformation and biological properties of an elasmobranchial insulin. Eur J Biochem. 1983 Oct 3;135(3):535-42. PMID:6352261

Strassburger W, Wollmer A, Pitts JE, Glover ID, Tickle IJ, Blundell TL, Steffens GJ, Günzler WA, Otting F, Flohé L. Adaptation of plasminogen activator sequences to known protease structures. FEBS Lett. 1983 Jul 4;157(2):219-23. PMID:6345197

Blundell TL, Bedarkar S, Humbel RE. Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors. Fed Proc. 1983 Jun;42(9):2592-7. PMID:6189745

Strassburger W, Glatter U, Wollmer A, Fleischhauer J, Mercola DA, Blundell TL, Glover I, Pitts JE, Tickle IJ, Wood SP. Calculated tyrosyl circular dichroism of proteins: absence of tryptophan and cystine interferences in avian pancreatic polypeptide. FEBS Lett. 1982 Mar 22;139(2):295-9. No abstract available. PMID:7075780

Gunning J, Bedarkar S, Taylor GL, Goodfellow JM, Blundell TL, Wlodawer A, Hodgson KO, Shooter EM, Fourme R, Gaber B, Williams R. Conformational studies of polypeptide growth factors: IGF and NGF. Prog Clin Biol Res. 1982;102 pt A:221-30. No abstract available. PMID:6762540

Blundell TL, Pitts JE, Wood SP. The conformation and molecular biology of pancreatic hormones and homologous growth factors. CRC Crit Rev Biochem. 1982;13(2):141-213. Review. No abstract available. PMID:6295698

Blundell TL, Pitts JE, Tickle IJ, Wood SP, Wu CW. X-ray analysis (1. 4-A resolution) of avian pancreatic polypeptide: Small globular protein hormone. Proc Natl Acad Sci U S A. 1981 Jul;78(7):4175-9. PMID:16593056 | PMCID:PMC319751

Gowan LK, Reinig JW, Schwabe C, Bedarkar S, Blundell TL. On the primary and tertiary structure of relaxin from the sand tiger shark (Odontaspis taurus). FEBS Lett. 1981 Jun 29;129(1):80-2. No abstract available. PMID:7274472

Blundell TL, Pitts JE, Tickle IJ, Wood SP. The conformation and receptor binding of pancreatic hormones. Biochem Soc Trans. 1981 Feb;9(1):31-2. No abstract available. PMID:6260550

Pitts JE, Wood SP, Hearn L, Tickle IJ, Wu CW, Blundell TL, Robinson IC. Crystallisation and preliminary crystallographic data of a porcine neurophysin I-Tyr-Phe-NH2 complex. FEBS Lett. 1980 Nov 17;121(1):41-3. No abstract available. PMID:7461119

Blundell TL, Humbel RE. Hormone families: pancreatic hormones and homologous growth factors. Nature. 1980 Oct 30;287(5785):781-7. Review. PMID:6107857

Narebor E, Slingsby C, Lindley PF, Blundell TL. Preliminary x-ray crystallographic study of the turkey lens protein, delta-crystallin. J Mol Biol. 1980 Oct 25;143(2):223-5. No abstract available. PMID:7218355

Horuk R, Blundell TL, Lazarus NR, Neville RW, Stone D, Wollmer A. A monomeric insulin from the porcupine (Hystrix cristata), an Old World hystricomorph. Nature. 1980 Aug 21;286(5775):822-4. PMID:6995860

Blundell TL, Sewell BT, McLachlan AD. Four-fold structural repeat in the acid proteases. Biochim Biophys Acta. 1979 Sep 29;580(1):24-31. PMID:44681

Blundell TL, Hearn L, Tickle IJ, Palmer RA, Morgan BA, Smith GD, Griffin JF. Crystal structure of [Leu5]enkephalin. Science. 1979 Jul 13;205(4402):220. No abstract available. PMID:451597

Tang J, James MN, Hsu IN, Jenkins JA, Blundell TL. Structural evidence for gene duplication in the evolution of the acid proteases. Nature. 1978 Feb 16;271(5646):618-21. PMID:24179

Wood SP, Tickle IJ, Blundell TL, Wollmer A, Steiner DF. Insulin polymorphism: some physical and biological properties of rat insulins. Arch Biochem Biophys. 1978 Feb;186(1):175-83. No abstract available. PMID:564664

Blundell TL, Bedarkar S, Rinderknecht E, Humbel RE. Insulin-like growth factor: a model for tertiary structure accounting for immunoreactivity and receptor binding. Proc Natl Acad Sci U S A. 1978 Jan;75(1):180-4. PMID:272633 | PMCID:PMC411209

Bedarkar S, Turnell WG, Blundell TL, Schwabe C. Relaxin has conformational homology with insulin. Nature. 1977 Dec 1;270(5636):449-51. No abstract available. PMID:593365

Wood SP, Pitts JE, Blundell TL, Tickle IJ, Jenkins JA. Purification, crystallisation and preliminary X-ray studies on avian pancreatic polypeptide. Eur J Biochem. 1977 Aug 15;78(1):119-26. PMID:913391

Subramanian E, Swan ID, Liu M, Davies DR, Jenkins JA, Tickle IJ, Blundell TL. Homology among acid proteases: comparison of crystal structures at 3A resolution of acid proteases from Rhizopus chinensis and Endothia parasitica. Proc Natl Acad Sci U S A. 1977 Feb;74(2):556-9. PMID:322132| PMCID:PMC392329

Pitts JE, Jenkins JA, Tickle IJ, Blundell TL, Wood SP. Structural studies on avian pancreatic polypeptide [proceedings]. Biochem Soc Trans. 1977;5(4):1119-20. No abstract available. PMID:913798

Jenkins JA, Tickle IJ, Sewell T, Blundell TL. The structure at 0.3nm (3A) resolution of the acid proteinase from Endothia parasitica [proceedings]. Biochem Soc Trans. 1977;5(4):1120-1. No abstract available. PMID:913799

Dockerill S, Blundell TL, Sasaki K, Tickle IJ, Wood SP. The relation of structure to storage and receptor binding of glucagon [proceedings]. Biochem Soc Trans. 1977;5(4):1121-2. No abstract available. PMID:199489

Beddell CR, Sheppey GC, Blundell TL, Sasaki K, Dockerill S, Goodford PJ. Symmetrical features in polypeptide hormone-receptor interactions. Int J Pept Protein Res. 1977;9(3):161-5. PMID:191417

Bedarkar S, Blundell TL, Dockerill S, Tickle IJ, Wood SP. Polypeptide hormone-receptor interactions: the structure and receptor binding of insulin and glucagon. Ciba Found Symp. 1977;(60):105-21. PMID:215391

Blundell TL, Dockerill S, Sasaki K, Tickle IJ, Wood SP. The relation of structure to storage and receptor binding of glucagon. Metabolism. 1976 Nov;25(11 Suppl 1):1331-6. No abstract available. PMID:185492

Pullen RA, Lindsay DG, Wood SP, Tickle IJ, Blundell TL, Wollmer A, Krail G, Brandenburg D, Zahn H, Gliemann J, Gammeltoft S. Receptor-binding region of insulin. Nature. 1976 Feb 5;259(5542):369-73. PMID:175286

Jenkins JA, Blundell TL, Tickle IJ, Ungaretti L. The low resolution structure analysis of an acid proteinase from Endothia parasitica. J Mol Biol. 1975 Dec 25;99(4):583-90. No abstract available. PMID:1214301

Blundell TL, Brunori M, Curti B, Martino B, Coda A, Fumagalli M, Ungaretti L. Crystallization and preliminary x-ray diffraction studies on met-myoglobin from Aplysia limacina. J Mol Biol. 1975 Oct 5;97(4):665-6. No abstract available. PMID:1185786

Blundell TL, Wood SP. Is the evolution of insulin Darwinian or due to selectively neutral mutation? Nature. 1975 Sep 18;257(5523):197-203. PMID:169474

Pullen RA, Jenkins JA, Tickle IJ, Wood SP, Blundell TL. The relation of polypeptide hormone structure and flexibility to receptor binding: the relevance of X-ray studies on insulins, glucagon and human placental lactogen. Mol Cell Biochem. 1975 Jul 31;8(1):5-20. PMID:170505

Wood SP, Blundell TL, Wollmer A, Lazarus NR, Neville RW. The relation of conformation and association of insulin to receptor binding; x-ray and circular-dichroism studies on bovine and hystricomorph insulins. Eur J Biochem. 1975 Jul 15;55(3):531-42. PMID:1175610

Blundell TL, Cutfield JF, Cutfield SM, Dodson EJ, Dodson GG, Hodgkin DC, Mercola DA. Three-dimensional atomic structure of insulin and its relationship to activity. Diabetes. 1972;21(2 Suppl):492-505. No abstract available. PMID:5054329

Blundell TL, Cutfield JF, Dodson EJ, Dodson GG, Hodgkin DC, Mercola DA. The crystal structure of rhombohedral 2 zinc insulin. Cold Spring Harb Symp Quant Biol. 1972;36:233-41. No abstract available. PMID:4508138

Blundell TL, Cutfield JF, Dodson GG, Dodson E, Hodgkin DC, Mercola D. The structure and biology of insulin. Biochem J. 1971 Dec;125(3):50P-51P. No abstract available. PMID:5169433 | PMCID:PMC1178203

Blundell TL, Cutfield JF, Cutfield SM, Dodson EJ, Dodson GG, Hodgkin DC, Mercola DA, Vijayan M. Atomic positions in rhombohedral 2-zinc insulin crystals. Nature. 1971 Jun 25;231(5304):506-11. No abstract available. PMID:4932997

Blundell TL, Dodson GG, Dodson E, Hodgkin DC, Vijayan M. X-ray analysis and the structure of insulin. Recent Prog Horm Res. 1971;27:1-40. Review. No abstract available. PMID:4946130