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Vacancies in the Department

Accounts Clerk [Temporary Cover] (Maternity Cover)

From Jobs at the University of Cambridge. Published on Nov 30, 2016.

We are seeking to appoint an Accounts Clerk to work as part of a small but busy team in the Department of Biochemistry.

You will be one of the primary points of contact for account enquiries and undertake a full range of support duties including accounts payable, accounts receivable and general ledger activities using the University's financial system, as well as dealing with post, filing and petty cash.

The successful candidate will possess the ability to work effectively in a team and have experience of dealing with customers and colleagues at all levels. Good time management, attention to detail, and ability to use their own initiative is essential.

Candidates should be educated to GCSE level, or equivalent, with at least five grades A* - C including English and Mathematics. Excellent communication skills are essential. Experience using Oracle Financials and iProcurement is desirable. Ideally, the successful candidate will have or be working towards their AAT qualification.

Maternity cover: This post is fixed-term for 1 year or the return of the post holder, whichever is the earlier.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be sent to Personnel - personnel@bioc.cam.ac.uk

Please quote reference PH10884 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

BBSRC-DTP CASE Studentship

From Jobs at the University of Cambridge. Published on Nov 09, 2016.

Optimization and development of functionally active anti-Cdc42/Ras peptides

A fully funded 4-year BBSRC-DTP Industrial CASE PhD studentship is available, commencing in October 2017, to develop peptide-based therapeutics designed to target Ras-driven cancers. The project builds on a considerable body of data generated in the academic research group led by Drs Darerca Owen and Helen Mott investigating the structure, thermodynamics and functions of small G protein-effector complexes, which has led to the development of candidate peptide therapeutics. The aim of the BBSRC-DTP Industry CASE awards is to provide PhD students with a first class, challenging training experience within the context of a mutually beneficial collaboration between academic and non-academic partner organizations. This project is partnered by MedImmune, a world-leading company specializing in antibody and peptide therapeutics, based just outside Cambridge. The work will use MedImmune's considerable experience to optimize peptides for use as cellular probes and as lead therapeutic molecules. Candidate peptides will be tested in the Owen/Mott laboratory using a range of biophysical and biochemical assays. Those peptides with desired properties will be taken into cell-based assays to test their effects on Ras signalling. The project will provide a thorough training in a wide range of state-of-the-art techniques: advanced peptide chemistry and high-throughput screening techniques; molecular biology, protein biochemistry, biophysics and NMR for protein-protein interaction analysis; cell culture assays e.g. cell proliferation, anchorage-independent growth and focus formation assays.

The successful candidate will join the group led by Drs Darerca Owen and Helen Mott (http://www.bio.cam.ac.uk/~hrm28/) in the Department of Biochemistry, University of Cambridge and will be part of the Antibody Discovery and Protein Engineering (ADPE) department at MedImmune, working alongside a skilled team of scientists in a dynamic biotech environment, supervised by Dr Jeff Revell (https://www.medimmune.com/).

Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject. BBSRC studentships are available to UK nationals and EU students who meet the UK residency requirements. Further information about eligibility for Research Council UK funding can be found on the BBSRC website: http://www.bbsrc.ac.uk/documents/studentship-eligibility-pdf/ The successful candidate will receive a stipend paid at RCUK rates for the 4 year duration of the award (£14,296 per annum for 2016-17) and in addition will benefit from a £2,500 per annum stipend enhancement; fees will be met in full for EU nationals.

Fixed-term: The funds for this post are available for 4 years in the first instance.

Applications should be sent to Dr Darerca Owen (do@bioc.cam.ac.uk), as soon as possible, and at the latest by 16th December 2016, enclosing a cover letter, a detailed curriculum vitae and the names and contact details of two academic referees. Interviews will be held in January 2017.

Please quote reference PH10700 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Four-year PhD Programme, Department of Biochemistry (Three Posts) (Fixed Term)

From Jobs at the University of Cambridge. Published on Nov 17, 2016.

Applications are invited for a four-year PhD programme through the generous support of AstraZeneca. The Department of Biochemistry is a member of the School of the Biological Sciences and one of the largest departments in the University of Cambridge. The Department is especially strong in research with investigators of international standing in a wide range of disciplines including structural biology, molecular enzymology, cell signalling and control of gene expression, molecular microbiology, plant molecular biology and bioenergy, cancer and cardiovascular biology.

Purpose and details - The programme aims to educate and train the next-generation doctoral scientists in all aspects of cutting edge biochemistry research which in the department focuses on the fundamental processes of biological systems, with a particular emphasis on understanding at the molecular level.

  1. Students awarded places on the programme will join a specific research group from the outset and undertake a research project agreed with the principal investigator.

  2. All students will have the opportunity to spend some time conducting research at the AstraZeneca Global Research and Development Centre in Cambridge.

  3. All students will receive a tailored career development programme and an AstraZeneca-based project supervisor (in addition to a Biochemistry based supervisor), designed to broaden their research and professional skills.

In addition to her/his direct supervisor, each PhD student will also have an advisor. Each student is also assisted by a graduate thesis panel comprising three members of faculty chosen by the student. Our PhD programmes offer many opportunities for both specialised training and the acquisition of transferable skills.

Applicants should have or shortly expect to obtain a minimum of a UK II.i Honours Degree (or equivalent) in Biochemistry or a related subject. Competition is intense and successful applicants will demonstrate very high academic achievements. We are looking for highly motivated, enthusiastic and industrious individuals who are capable of thinking and working independently.

Application process - You should identify one or more labs in which you might wish to study, then make informal contact with the principal investigator(s) to ensure they are potentially able to supervise you, and to understand the research project you would undertake.

To find PIs' areas of research see Research Group Heads http://www.bioc.cam.ac.uk/people/uto

When making informal contact with the PI, please e-mail the following information to them:

  1. Your CV (max two A4 pages), with full contact details of 2 academic referees.

  2. A covering letter (max two A4 pages) highlighting (a) your research interests, (b) what you hope to achieve from the programme, (c) your career aspirations beyond the programme, and (d) why you wish to undertake this programme in the Department of Biochemistry.

The email addresses of the PIs can be found at http://www.bioc.cam.ac.uk/graduate/apply

If you receive support from the PI you should apply using the Applicant Portal which can be found at: http://www.graduate.study.cam.ac.uk/how-do-i-apply. You can only submit one application with one PI for consideration. Multiple applications with different PIs will not be accepted. Fully completed applications (including references) must be submitted by the deadline.

Funding - Full funding covering the University Composition Fee (at UK/EU rates), Maintenance (currently £17,000 pa), and an allowance for consumables is provided for up to 4 years, with effect from 1 October 2017.

Fixed-term: The funds for this post are available for 4 years in the first instance.

If you have any questions please in the first instance forward your enquiry to our Graduate Admissions Administrator at pg-entry@bioc.cam.ac.uk.

The closing date for applications is 12 noon on 3rd January 2017. Interviews will be held on 18th and or 19th January 2017.

Please quote reference PH10696 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD Studentship in Evolutionary Microbiology of a Human Pathogen

From Jobs at the University of Cambridge. Published on Nov 01, 2016.

A fully-funded PhD studentship from the National Centre for Replacement, Refinement and Reduction (NC3R) is available for uptake in October 2017 in the laboratories of Dr Martin Welch (Department of Biochemistry, Tennis Court Road, Cambridge) and Prof Andres Floto (Laboratory of Molecular Biology and Papworth Hospital, Cambridge). Most of the hands-on work will be done in the MW laboratory.

The project is entitled "In vitro reconstitution of the polymicrobial community associated with cystic fibrosis (CF) airway infections". The airway infections associated with many (if not most) chronic respiratory diseases are predominantly polymicrobial, yet there are currently no models mimicking polymicrobial respiratory infection in vitro and the developing animal models are still very rudimentary. We therefore have an unparalleled window of opportunity in which to develop a robust, experimentally-tuneable in vitro model of polymicrobial respiratory infection. This will be the main aim of the project. The ability to work with stable polymicrobial communities will allow us to address some important ecological and evolutionary questions. For example, what happens to the community structure and dynamics when it is perturbed following antibiotic addition? What happens when a new species is introduced? Does co-culturing of different species affect their phenotypes, cell-cell communication or virulence profiles? These are fascinating fundamental questions that can be directly addressed using an in vitro setup. This PhD project would be suitable for a candidate with a background in Biology, Biochemistry, Microbiology or Genetics and a desire to apply the very latest modern molecular biological techniques to address a variety of unanswered ecological and evolutionary questions.

The successful applicant will join our Departmental PhD programme and must complete their studies within 4 years. Full funding (covering maintenance, fees and laboratory consumables) is available for UK citizens or EEA students who meet UK residency requirements. NC3Rs-specific training will be supplied, and is an integral part of the training programme.

Fixed-term: The funds for this post are available for 3 years in the first instance.

In the first instance, interested candidates should contact Dr Martin Welch (mw240@cam.ac.uk) with a CV, list of academic referees and a cover letter. Shortlisted candidates will be invited for interview in Cambridge.

Please quote reference PH10614 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD Studentship in Molecular Microbiology

From Jobs at the University of Cambridge. Published on Oct 18, 2016.

A BBSRC-funded Targeted PhD studentship (for uptake in October 2017) is available in the laboratory of Dr Martin Welch (Department of Biochemistry, Tennis Court Road, Cambridge). The project will investigate the role of an acetate-inducible denitrification pathway in the opportunistic human pathogen, Pseudomonas aeruginosa. Recent RNA-Seq analyses carried out in the lab have revealed that when grown on acetate as a sole carbon source, gene products comprising the Nar/Nir/Nos/Nor denitrification pathways are among the most highly up-regulated transcripts in the cell. This was a surprising observation because transcripts encoding the known regulators of denitrification in P. aeruginosa (Anr and Dnr) were not modulated at all, suggesting that in these conditions, denitrification is controlled by some other mechanism(s). The practical relevance of this is that (i) fatty acids and other acetate-producing substrates are now known to be the preferred energy source for P. aeruginosa during many infection scenarios, and (ii) denitrification is critically-important in industry for microaerobic bacterial growth.

Therefore, the key question and the main aim of this project, is to understand why P. aeruginosa turns on the denitrification pathways during growth on acetate, and what regulates this. The successful candidate will investigate this problem using a combined biochemical, genetic and systems-based approach which should provide a rich and varied training opportunity.

The successful applicant will join our Departmental PhD programme and must complete their studies within 4 years. Full funding (covering maintenance, fees and laboratory consumables) is available for UK citizens or EEA students who meet UK residency requirements. In addition to a programme of work in the MW lab, the appointed student will participate in DTP training courses, two 10-week rotation projects (one of which will be based in the MW lab) and a three month internship (PIPS), as well as other DTP-related events.

Fixed-term: The funds for this post are available for 4 years in the first instance.

In the first instance, interested candidates should contact Dr Martin Welch (mw240@cam.ac.uk) with a CV, list of academic referees and a cover letter. Shortlisted candidates will be invited for interview in Cambridge.

Please quote reference PH10464 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Dec 01, 2016.

A position has arisen in the lab of Professor Gerard Evan, University of Cambridge, Department of Biochemistry, Cambridge (http://www.bioc.cam.ac.uk/uto/evan) to further our ongoing studies on the role of the myc oncogene in haematopoeitic malignancies. The Myc protein is a highly pleiotropic "master" switch that modulates a wide variety of mechanistically diverse processes. Its aberrant expression is implicated in several haematological malignancies, including acute myeloid leukaemia. The lack of pharmacological inhibitors of Myc has hampered the investigation of the role of Myc in the genesis and maintenance of these cancers and the therapeutic efficacy of Myc inhibition. To address this we have established animal models in which we can rapidly and reversibly switch the expression or activity of Myc in haematopoeitic cell lineages. We now seek a postdoctoral researcher to continue our studies investigating the effects of deregulated oncogenic Myc expression (a common finding in many tumours) in these tumours.

Applicants must have a PhD or equivalent, a strong background in tumour biology and previous experience in molecular and cellular biology and in mouse models of tumourigenesis.

A Home Office Personal licence is also required.

Fixed-term: The funds for this post are available for two years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be sent to Trevor Littlewood - tdl2@cam.ac.uk.

Please quote reference PH10892 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.