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Vacancies in the Department

BBSRC CASE 4-year PhD Studentship (Fixed Term)

From Jobs at the University of Cambridge. Published on Aug 12, 2015.

The Department of Biochemistry is offering a BBSRC CASE 4-year PhD studentship starting in January 2016

The aim of the studentship is to determine the molecular basis of interactions between African trypanosomes and their mammalian hosts, supervised by Professor Mark Carrington in the Department of Biochemistry and Dr Andrea Gonzalez-Munoz at Medimmune. The successful applicant will spend time working at both the Medimmune Research Labs (www.medimmune.com) close to Cambridge and in the Carrington lab (www.mctryps.org/mclab/Home.html) in the Department of Biochemistry (www.bioc.cam.ac.uk).

The studentship is open to UK and other EU nationals and other who qualify for fees at the 'Home' rate, see www.graduate.study.cam.ac.uk/finance/fees/what-my-fee-status

The deadline for applications is Friday 18 September 2015. Applications received after this time will not be considered.

Fixed-term: The funds for this post are available for 4 years in the first instance.

For details of the project and to apply please send a CV, the names and contact details of two academic referees along with a covering letter to Professor Mark Carrington - mc115@cam.ac.uk

Please quote reference PH06864 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Postdoctoral Research Associate in Protein Engineering: Directed Evolution and Mechanistic Analysis (Fixed Term) (Fixed Term)

From Jobs at the University of Cambridge. Published on Jul 31, 2015.

A postdoctoral position is available for 9 months (with a possibility of extension) from 15 September 2015 (or later) to work with Florian Hollfelder based in the University of Cambridge, Department of Biochemistry, Central Cambridge on in vitro directed evolution and mechanistic analysis of promiscuous enzymes (i.e. enzymes with multiple activities).

We will base directed evolution of new generalists and specialists on measurement of fitness landscapes of randomised protein populations: such distribution functions for multiple activities will be gathered by ultrahigh-throughput screening of >106 clones in picolitre droplet compartments during in vitro evolution cycles, followed by systematic characterization of multiple fitness traits such as expression level, stability or reaction kinetics. We will also test how directed evolution of thermostable analogs differs frm that of enzymes with low-temperature activity peaks. These approaches will enable a dynamic picture of protein evolution at various levels from transition state recognition, protein biophysics to population genetics. The work is part of the EU Marie-Curie IAAP network 'HotDrops' (http://hotdrops.cbm.uam.es/index.php)

Candidates should have skills in protein engineering, directed evolution, kinetic analysis of enzyme catalysis, chemical biology techniques, molecular biology techniques, biophysical analysis of proteins.

Candidates should have a PhD in a relevant subject/have recently submitted or the equivalent.

Fixed-term: The funds for this post are available for 9 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be made to Dr Florian Hollfelder - fh111@cam.ac.uk. Any enquiries relating to the application process please contact the personnel secretary - personnel@bioc.cam.ac.uk

Please quote reference PH06749 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate - Structural Biology of Membrane Proteins (Fixed Term)

From Jobs at the University of Cambridge. Published on Aug 18, 2015.

A postdoctoral Research Associate position is available to work on the structural biology of mammalian membrane proteins using the latest technology in X-ray crystallography. The post is based in the laboratory of Dr Simone Weyand, University of Cambridge, Departmental of Biochemistry, Central Cambridge and is for 1 year initially.

The role involves the ideal candidate to carry out all the steps from cloning to structure determination of a human GPCR. The successful candidate will be highly motivated with a track record of working on integral membrane proteins and expertise in at least one, and preferably more, of the following areas: over-expression in insect or mammalian cells, membrane protein purification, and X-ray crystallography structure determination. Candidates must be self-motivated individuals who enjoy working as part of a collaborative and multidisciplinary team. Strong leadership, communication and teamwork skills are decided assets.

Candidates should hold a PhD or the equivalent in a relevant specialist subject or have recently submitted for a PhD.

Fixed-term: The funds for this post are available for 1 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal inquiries can be made to Dr Simone Weyand- sw644@cam.ac.uk

Please quote reference PH06900 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate in Bioinformatics for Mass Spectrometry (Fixed Term)

From Jobs at the University of Cambridge. Published on Aug 14, 2015.

Postdoctoral positions in lipidomics and metabolomics

A postdoctoral research associate position is available for up to three years (12 months in the first instance) to work in the laboratory of Dr J.L. Griffin, University of Cambridge, Department of Biochemistry, Tennis Court Road, Cambridge. The project will develop tools to measure lipid species in conjunction with ion mobility, an exciting development in mass spectrometry which will allow the separation of ions according to their cross sectional area as well as their mass to charge ratio. It is envisaged that the successful candidate will work alongside an experienced mass spectrometrist involved in method development, whilst developing new software tools for processing the data obtained.

We are looking for an bioinformatician with experience in processing biological mass spectrometry data or other relevant experience such as experience in signal processing. The work is a collaborative project between Dr. J.L Griffin (Dept of Biochemistry), Prof. Michael Wakelam (Babraham Institute) and Agilent technology. As part of this project the research associate will have access to a state of the art ion mobility Q-ToF LC-MS to develop new tools for lipidomics, and building on our work in diabetes and metabolic diseases (Griffin) and cancer (Wakelam) use the instrument to explore cellular signalling in these disease processes. Some examples of this work can be found in Roberts LD et al., Lancet Endocrinology, 2014; Roberts LD et al., Methods in Enzymology, 2014; Zhang Q & Wakelam MJ, Adv Biol Regul 2014.

Skills required are bioinformatics for metabolomics or proteomics and a general interest in metabolism and disease processes in mammals. Previous work in metabolomics and/or lipidomics would be an advantage but we will consider relevant experience in other areas such as aspects of signal processing

Applicants should have a PhD or are about to submit or have the equivalent in a relevant science.

Fixed-term: The funds for this post are available for 12 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal inquiries can be made to Dr J.L Griffin - jules.griffin@mrc-hnr.cam.ac.uk

Please quote reference PH06024 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate x 2 in Structural Biology: Structural basis of meiotic chromosome organization by the synaptonemal complex (Fixed-term)

From Jobs at the University of Cambridge. Published on Aug 28, 2015.

Research Associates in Structural Biology: Structural basis of meiotic chromosome organisation by the synaptonemal complex and associated proteins.

Two postdoctoral positions are available in the group of Dr. Luca Pellegrini in the Department of Biochemistry of the University of Cambridge in Central Cambridge, to work on the essential role of the synaptonemal complex in establishing the functional architecture of parental chromosomes in meiosis, which is essential for correct pairing and recombination (Davies et al, Open Biology, 2012; Syrjanen et al, eLife, 2014). A multi-disciplinary approach involving biochemical, biophysical and cellular experiments will be used to elucidate the molecular mechanisms of synaptonemal complex assembly on the meiotic chromosome axis. The ultimate goal of the project is to advance our understanding of meiotic chromosome organisation, by means of biochemical reconstitution and structural characterisation using purified protein components.

Candidates will hold or about to be awarded a PhD in Biochemistry, Biophysics, Molecular Biology or the equivalent and must have a proven track record of research achievements. Previous experience in the analysis of multi-protein complexes and protein-DNA interactions, as well as familiarity with biophysical techniques such as X-ray crystallography, electron microscopy and single-particle analysis would be an advantage. One of the positions would be suitable for candidates trained in cellular biology and with an interest in the study of molecular mechanisms.

The positions are available from November 1st, 2015.

Fixed-term: The funds for this post are available for 3 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be made to Luca Pellegrini at lp212@cam.ac.uk.

Applicants should submit a CV with list of relevant publications, a cover letter explaining why they are suitable for the position and the contact details of at least two referees.

Please quote reference PH06670 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.