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Vacancies in the Department

Laboratory Manager

From Jobs at the University of Cambridge. Published on Jul 06, 2015.

We are seeking a Laboratory Manager to work with the Antibiotic Biosynthesis research group headed by Professor Peter Leadlay. The group (currently 15+ researchers) and the associated Next-Generation (NextGen) DNA- and RNA-Sequencing facility (5 technical staff and a research assistant) represents a major axis of research in the Department of Biochemistry.

You will provide a range of essential support services to the research group including the curation and organisation of a significant microbiological collection of antibiotic-producing actinomycete bacteria, and the provision of advice and technical support in their study and use for antibiotic discovery. In addition you will control the ordering of chemicals and other supplies, undertake evaluation of major new equipment including negotiation with suppliers and ensuring compliance with University purchasing procedures, and maintain oversight of budgets for each project. You will be responsible for COSHH-associated chemical regulations and for compliance with biological health and safety regulations. There will also be the opportunity to provide technical assistance to postdoctoral researchers on specific projects including genome sequencing and analysis, and biochemical and genetic studies towards the synthetic biology of antibiotic biosynthesis.

A degree in biological sciences or related subject is desirable. Previous laboratory management experience and safety responsibility is essential.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquires can be obtained from Professor Peter Leadlay (pfl10@cam.ac.uk).

Please quote reference PH06519 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate in Protein Engineering: Directed Evolution and Mechanistic Analysis of Therapeutic Proteases (Fixed Term)

From Jobs at the University of Cambridge. Published on Jun 30, 2015.

A postdoctoral position is available for 12 months (with a possibility of extension) from 1st August 2015 (or later) to work in the group of Dr Florian Hollfelder in the University of Cambridge, Department of Biochemistry, Tennis Court Road, Central Cambridge on identification and protein engineering of protease enzymes as potential therapeutics. The project will explore the substrate promiscuity of existing proteases as a prelude to adapting them for new targets by directed evolution. To this end directed evolution of proteases will be carried out using ultra-high-throughput screening in microfluidic droplets. Kinetic and biophysical analysis will be used to analyse the mechanisms of substrate recognition and catalysis of the new biocatalysts. Ultimately we hope to develop them into therapeutic molecules.

This project is a collaboration with Drs. Nat Gordon, Lutz Jermutus and others at MedImmune, the biologics arm of AstraZeneca based in Cambridge.

Candidates should have skills in molecular and chemical biology, protein engineering and kinetic analysis of enzymes.

Candidates should have a PhD or the equivalent or has recently submitted for a PhD in a relevant science.

Fixed-term: The funds for this post are available for 12 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal inquiries can be made to Florian Hollfelder - fh111@cam.ac.uk

Please quote reference PH05105 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Data Technician (Fixed Term)

From Jobs at the University of Cambridge. Published on Jun 23, 2015.

Cambridge Centre for Proteomics (CCP) in the University of Cambridge is currently looking to recruit a Research Data Technician within its core facility unit. The core facility offers proteomics services to users from the University of Cambridge and other worldwide academic and industrial groups.

The successful candidate will be required to analyse high-throughput proteomics datasets using standard proteomic packages and apply common statistical methods to the datasets. Some degree of programming literacy would be advantageous, preferably R. The role-holder will be an integral member of CCP and will need to interact closely with other members of CCP and internal and external users of the service to provide interpretation of results from complex datasets. Previous proteomics experience isn't essential although it will necessary for candidates to demonstrate evidence that they have previously analysed large datasets. In addition, familiarity with pipeline development would be desirable.

The successful candidate will ideally have a first degree in bioinformatics or biological sciences with demonstrable experience in data analysis.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal inquiries can be made to Mike Deery - md289@cam.c.uk

Please quote reference PH05266 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.