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Vacancies in the Department

Catering Assistant

From Jobs at the University of Cambridge. Published on May 11, 2017.

We are seeking a reliable, outgoing and conscientious person to join our small catering team.

The duties consist of the setting up and clearing down of service areas, helping with basic food preparation tasks, serving of food, operating tills, cleaning, re-stocking, monitoring and recording food temperatures, together with washing up. Support for functions and events will also be required as necessary.

Experience of working in a similar role/environment is preferred but full training will be provided if necessary.

Further Particulars can be obtained from Amy Marshall - Facilities Manager (facilities@bioc.cam.ac.uk)

The hours of work will be Monday to Friday from 8.30am to 4.30pm with a break of lunch of 45 minutes.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PH12185 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

EU Marie-Curie PhD Studentship (ES-Cat)

From Jobs at the University of Cambridge. Published on May 02, 2017.

PhD Studentship in Directed Protein Evolution for Synthetic Biology and Biocatalysis

Department of Biochemistry, University of Cambridge

Quote Reference: PH12082

A graduate studentship leading to the award of a PhD is available from 1 September 2017 (or later) to work at Cambridge University in the Biochemistry Department (with Dr. F. Hollfelder - http://www.bioc.cam.ac.uk/hollfelder). The studentship is in the context of the EU Marie-Curie network ES-Cat (http://www.bioc.cam.ac.uk/hollfelder/Research/es-cat) on Directed Protein Evolution for Synthetic Biology and Biocatalysis.

Efficient exploration of sequence space requires new technologies that connect genotype and phenotype. Using droplet compartmentalization we have developed systems in which evolution of binders (e.g. SNAP-display) or catalysts in possible completely in vitro. These powerful technologies will be further developed, to select functional proteins from large libraries, so that they have programmed binding and recognition properties. We hope to develop strategies for evolution that are inspired by insight into enzyme mechanism that will enhance our understanding of how enzyme accelerate reactions.

Candidates will be mainly based in the Biochemistry Department (in central Cambridge), but also work for extended secondments in the labs of the academic and industrial network partners (http://www.bioc.cam.ac.uk/hollfelder/Research/es-cat/es-catfront#partnerlist). All students take part in a training programme that includes workshops, meetings and courses given by all network partners.

Applicants should have a first (or upper second) class degree in biochemistry, biotechnology, chemistry or a related, relevant subject. Specific skills in protein engineering, directed evolution, chemical and kinetic analysis of enzyme mechanisms, organic synthesis and familiarity with molecular biology techniques (e.g. phage or ribosome display, cloning, DNA manipulation, preparation and handling of DNA libraries) are advantages.

The full stipend will be paid at rates of the EU Marie-Curie programme for the 3 year duration of the award.

Applications should contain a description of your research interests (e.g. as part of the cover letter) and your detailed CV (with exam marks and all relevant practical experience). Please also include the names and email-addresses of at least two referees, who know you from your courses or laboratory research work. Send your application by email to studentships@bioc.cam.ac.uk (quoting reference PH12082).

Closing Date: 25 May 2017. Limit of tenure: Up to 36 months.

Please quote reference PH12082 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD Studentship

From Jobs at the University of Cambridge. Published on Apr 19, 2017.

A fully funded 4-year BBSRC PhD studentship under the MedImmune Collaborative Training Partnership (CTP) is available, commencing in October 2017, to investigate why some monoclonal antibodies (mAbs) fail to be properly secreted by Chinese hamster ovary (CHO) cells. The aim of the BBSRC CTP awards is to provide PhD students with a challenging research training experience within the context of a mutually beneficial research collaboration, between academic and industrial partner organisations. This project is partnered by MedImmune, the global biologics research and development arm of AstraZeneca specializing in antibody and protein therapeutics, at its Cambridge R&D site. The work will utilise MedImmune's considerable experience in developing CHO cell lines engineered for the production of therapeutic mAbs. It will involve characterisation of mAbs across a spectrum of secretion properties, from those which are effectively delivered in growth media to those that are very poorly secreted, often with an increased unfolded protein response and with retention in the cell.

The student will employ novel methodologies developed in the laboratory of Professor Kathryn Lilley in the Cambridge Centre for Proteomics (CCP) (http://proteomics.bio.cam.ac.uk/), focussed on the development and application of spatial proteomics methods that aim to accurately locate proteins to subcellular structures on a proteome wide scale 1. Her group has developed other methodologies which determine the components of multi-protein complexes and the spatial context of membrane proteins 2.

The outcome from the project will be a better understanding of the mechanisms involved in the secretion of recombinant mAbs, especially in cases where secretion is impaired. Knowing the interacting partners and location of retarded recombinant mAbs will assist in the design of future therapeutic proteins and cell engineering platforms to ensure their efficient secretion. This is of vital importance in the generation of manufacturing cell lines for therapeutic protein production.

The successful candidate will be jointly supervised by Prof. Kathryn Lilley of CCP, which is located in the Department of Biochemistry, University of Cambridge, and by science leaders from the Cell Line Development and Engineering team at MedImmune, working alongside a skilled team of scientists in a dynamic biopharmaceutical environment (https://www.medimmune.com/).

Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject. BBSRC studentships are available to UK nationals and EU students who meet the UK residency requirements.

Further information about eligibility for Research Council UK funding can be found on the BBSRC website: http://www.bbsrc.ac.uk/documents/studentship-eligibility-pdf/ The successful candidate will receive a stipend paid at RCUK rates for the 4 year duration of the award (£14,296 per annum for 2016-17); fees will be met in full for EU nationals meeting BBSRC residency requirements.

Fixed-term: The funds for this post are available for 4 years in the first instance.

Applications should be sent to Prof. Kathryn Lilley (k.s.lilley@bioc.cam.ac.uk), as soon as possible, and at the latest by 31st May 2017, enclosing a cover letter, a detailed curriculum vitae and the names and contact details of two academic referees. Interviews will be held in June 2017.

1 Christoforou, A. et al. A draft map of the mouse pluripotent stem cell spatial proteome. Nat Commun 7, doi:10.1038/ncomms9992 (2016). 2 Rees, J. S., Lilley, K. S. & Jackson, A. P. SILAC-iPAC: A quantitative method for distinguishing genuine from non-specific components of protein complexes by parallel affinity capture. Journal of Proteomics 115, 143-156, doi:http://dx.doi.org/10.1016/j.jprot.2014.12.006 (2015).

Please quote reference PH11008 on your application and in any correspondence about this vacancy.

Please quote reference PH11008 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Postdoctoral Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Apr 20, 2017.

DNA repair is crucial in all living cells for the maintenance of genome stability. The majority of spontaneous DNA lesions arise from the intrinsic chemical instability of DNA and include thousands of DNA single-strand breaks (SSBs) that occur on a daily basis. If left unrepaired, SSBs can terminate gene transcription, leading to mutations, cell death and disease, including premature ageing, cancer and progressive neurodegeneration.

We are looking to recruit a highly motivated and enthusiastic Postdoctoral Research Associate to investigate the novel functions of the ATM kinase in SSB repair (Khoronenkova & Dianov, PNAS, 2015; Khoronenkova et al., Mol Cell, 2012). We will determine the molecular mechanisms by which ATM is activated by SSBs. We will also investigate whether SSB repair deficiencies are linked to the genetic instability and neurodegenerative phenotypes of Ataxia Telangiectasia, caused by mutations in the ATM gene. The project will use biochemical in vitro assays and in vivo targeting of DNA nucleases to defined genomic loci, patient-derived induced pluripotent stem cells, CRISPR/Cas9 editing, confocal microscopy and state-of-the-art biochemical and proteomic approaches.

The post holder will join the laboratory of Dr Svetlana Khoronenkova at the Department of Biochemistry, University of Cambridge, United Kingdom.

Applicants should have a PhD (DPhil) in Biochemistry or Molecular/Cell Biology and a strong biochemical background. Previous experience in the fields of stem cell biology and/or DNA repair would be an advantage.

Fixed-term: The funds for this post are available for 36 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

For informal enquiries please contact Dr Svetlana Khoronenkova at sk870@cam.ac.uk.

Any enquires regarding the application process can be directed to Adriana Dote (personnel@bioc.cam.ac.uk).

Please quote reference PH11985 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Apr 18, 2017.

A postdoctoral position is available in the group of Ben Luisi in the Department of Biochemistry of the University of Cambridge in Central Cambridge, to work on RNA mediated gene regulation in bacteria. (Bandyra et al. (2012) Mol Cell; Strahl et al. (2015) PLoS Genetics; Dimastrogiovanni et al. (2014) eLife). A multi-disciplinary approach involving biochemical, biophysical and cellular experiments will be used to elucidate the molecular mechanisms of regulatory RNA recognition and action to modulate gene expression. The ultimate goal of the project is to advance our understanding of RNA based regulation, by means of biochemical reconstitution and structural characterisation using purified protein components.

Candidates will hold or about to be awarded a PhD in Biochemistry, Biophysics or Molecular Biology and must have a proven track record of research achievements. Previous experience in the analysis of multi-protein complexes and protein-RNA interactions, as well as familiarity with biophysical techniques such as X-ray crystallography, electron microscopy and single-particle analysis would be an advantage. The position would also be suitable for candidates trained in cellular biology and with an interest in the study of molecular mechanisms in vivo.

Applicants should submit a CV with list of relevant publications, a cover letter explaining why they are suitable for the position and the contact details of at least two referees.

Informal queries can be made to Ben Luisi (bfl20@cam.ac.uk).

Fixed-term: The funds for this post are available for 36 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Any enquires regarding the application process can be directed to Adriana Dote (personnel@bioc.cam.ac.uk).

Please quote reference PH11907 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on May 22, 2017.

A one year junior research associate position is available for a postdoc with a track record in structure function studies and protein purification work in Cys-loop receptors. Expertise of electrophysiology and cell culture is essential. S/he would join a small friendly group studying the mechanism of action of these proteins.

Fixed-term: The funds for this post are available for 12 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PH12278 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on May 12, 2017.

A postdoctoral research associate position is available for 1 year in the lab of Professor Nick Gay to study synergy between the Toll-like receptor and inflammasome signalling pathways.

The successful candidate will have a PhD in a related area of signalling and expertise in mammalian cell culture, phospho amino acid mapping, immunoprecipitation and fluorescence confocal microscopy.

Fixed-term: The funds for this post are available for 12 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PH12197 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on May 22, 2017.

Applications are invited for a Postdoctoral Research Associate position in Prof Christopher Howe's lab as part of the Cambridge OpenPlant Synthetic Biology Centre. OpenPlant is a joint initiative between the University of Cambridge, John Innes Centre, the Sainsbury Laboratory and the Earlham Institute, funded by BBSRC and EPSRC.

This position is aimed at identifying regulatory elements of cyanobacterial genes enabling control of gene expression in response to environmental electrical potential. Prof Howe's group has pioneered the development of 'biophotovoltaic' systems (McCormick et al. (2015) Energy & Environmental Science 8:1092) for the generation of electrical power from photosynthetic microorganisms. This post will analyse the transcriptional responses of cyanobacteria in biophotovoltaic devices.

Experience in the molecular biology of cyanobacteria, and in recombinant DNA techniques applied to microorganisms is essential. A PhD in a relevant subject is essential. Experience of electrochemistry is desirable, but not essential.

The appointee needs to be able to take up the post by 1 Sept 2017.

Fixed-term: The funds for this post are available for 24 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PH12279 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on May 02, 2017.

A postdoctoral position is available in the group of Dr Marko Hyvonen at the Department of Biochemistry to work on a BBSRC funded translational project to develop engineered growth factors for regenerative medicine and stem cell applications.

Candidates will hold a PhD in Biochemistry, Biophysics or Molecular Biology and must have a proven track record of research achievements. Significant experience in producing, purifying and analysing disulphide-rich proteins is essential, as is expertise in cell-based activity assays and biophysical characterisation of macromolecules and their interactions. Knowledge of structural analysis of proteins and structure-guided engineering is highly desired. Experience in working with stem cells would be an advantage.

The candidate must be able to work independently to set targets and milestones and have great attention to detail.

Applicants should submit a CV, a one page cover letter explaining why they are suitable for the position and the contact details of at least two academic referees. Informal queries can be made to Marko Hyvonen (mh256@cam.ac.uk).

Fixed-term: The funds for this post are available for 24 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PH12085 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.