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Vacancies in the Department

Bioinformatician in Metabolomics (Fixed Term)

From Jobs at the University of Cambridge. Published on Feb 03, 2017.

Are you interested how metabolism affects human health? An exciting opportunity to work in the area of Big Data has arisen for the appointment of a Research Assistant / Associate to support the development of advanced computational workflows for the processing of metabolic data. Using state of the art NMR spectroscopy and Mass Spectrometry, human and other tissues are processed to obtain complex spectra which, through careful analysis can led to many important medical breakthroughs e.g. novel biomarkers, measures of the effectiveness of drug treatments (precision and stratified medicine) or the discovery of key underlying biological mechanisms.

The project: Metaboflow, funded by the Wellcome Trust, is part of a consortium of leading UK Universities with a deep interest in metabolomics. The expertise this group has developed over many years of research in data collection, analysis and interpretation will be embedded in a series of Galaxy workflows to enable robust, fast and efficient processing of metabolomics data.

This post is based in the Department of Biochemistry, University of Cambridge but will work closely with colleagues at the European Bioinformatics Institute, Imperial College London, Manchester University and Birmingham University.

Working as part of a team, the post holder will develop new workflows for processing data obtained from NMR spectroscopy and Mass Spectrometry. This involves a number of stages from the instrument to the final data analysis stages. We are particularly interested in processing high throughput lipidomic data and mass spectrometry imaging, and will work closely with colleagues in Manchester.

The candidate should have a BSc in Computational Biology or Computer Sciences or an area with high relevance to software development in the life sciences for appointment as Research Assistant. A PhD in this area is essential for appointment as Research Associate. You must have significant experience in programming (e.g. in languages such as C++, Java) and be conversant with prototyping environments such as Matlab and R. The objective is to work in a number of key areas that are obstacles to progress in the metabolomics area such as the processing of high throughput metabolomics/lipidomics data, and mass spectrometry imaging of tissues for histology.

Good team working skills will be essential as will excellent communication skills and ability to work to deadlines whilst maintaining a high level of accuracy.

Fixed-term: The funds for this post are available for 24 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be directed to Professor Jules Griffin (jlg40@cam.ac.uk).

Any enquires regarding the application process can be directed to Adriana Dote (personnel@bioc.cam.ac.uk).

Please quote reference PH11352 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Building Services Technician (Plumbing Lead)

From Jobs at the University of Cambridge. Published on Feb 07, 2017.

A Building Service Technician (Plumbing Lead) is required to work in the University of Cambridge, Department of Biochemistry.

The successful applicant will join a small proactive team of three staff under the guidance of the Building Services Manager. The duties of the role include to support both teaching and research within The Department by providing a frontline service. Further duties of the role will be to monitor key plant and equipment, respond to breakdowns, conduct minor plumbing and building repairs / alterations, establish and carry out a range of routine and planned maintenance and minor building works as directed. Since an additional key part of this role will be to act as the Plumbing Lead within The Maintenance Team, the successful candidate will be competent and knowledgeable in the operation of general water, Air Handling Units and heating plant and the setting of control equipment associated with domestic, laboratory, softened and deionised water services.

One of the largest Department's in The School of Biological Sciences, Biochemistry has varied research activities using complex plant and services to maintain a workable environment for researchers and equipment. The Department occupies two main buildings; both being highly serviced by a large amount of plant equipment supporting a number of high-specification Laboratories. The successful Candidate will be expected to familiarise themselves with the numerous plant rooms in order to guide engineers and contractors when required.

The successful applicant will be able to work in a team, be computer literate and with a good attention to detail. Communication and interpersonal skills are essential as the role holder is required to deal with different personnel both from within The University and outside contractors on a daily basis.

Candidates should hold an industry recognised qualification (eg., BTEC National certificate, City & Guilds, NVQ or equivalent).

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Enquires relating to this role should be directed to Roger Biamonti (rb686@cam.ac.uk).

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Any enquires regarding the application process can be directed to Adriana Dote (personnel@bioc.cam.ac.uk).

Please quote reference PH11380 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Herchel Smith Professor of Biochemistry

From Jobs at the University of Cambridge. Published on Jan 11, 2017.

The Board of Electors to the Herchel Smith Professorship of Biochemistry invite applications from outstanding established investigators for this Professorship. The Herchel Smith Professorship of Biochemistry is one of two established and fully endowed Professorships within the Biochemistry department and is funded by a generous bequest from the eponymous Anglo-American Organic Chemist.

Candidates will have an outstanding research record of international stature in their field. They will demonstrate the vision, leadership, experience and enthusiasm to build on current strengths and developing a leading research presence within Biological Sciences, across the University and through broader collaboration. A PhD or equivalent postgraduate qualification is essential.

Standard professorial duties include teaching and research, examining, supervision and administration. The Professor will be based in Cambridge.

The appointment comes with a substantial endowment and a start-up package to be negotiated, together with a competitive salary. The appointment will be from 1 October 2017 or as soon as possible thereafter.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Further information is available at: http://www.hr.admin.cam.ac.uk/professorships or contact Human Resources, University Offices, The Old Schools, Cambridge, CB2 1TT, (email: ibise@admin.cam.ac.uk).

Applications, consisting of a letter of application, a statement of current and future research plans, a curriculum vitae and a list of publications, along with details of three referees should be made online no later than 13 March 2017.

Informal enquiries may be directed to Professor Gerard Evan, Head of the Department of Biochemistry; tel: +44 1223 766017, email: gie20@cam.ac.uk.

Please quote reference PH11136 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD Studentship (Fixed Term)

From Jobs at the University of Cambridge. Published on Feb 07, 2017.

A fully funded 4-year BBSRC PhD studentship under the MedImmune Collaborative Training Partnership (CTP) is available, commencing in October 2017, to investigate why some monoclonal antibodies (mAbs) fail to be properly secreted by Chinese hamster ovary (CHO) cells. The aim of the BBSRC CTP awards is to provide PhD students with a challenging research training experience within the context of a mutually beneficial research collaboration, between academic and industrial partner organisations. This project is partnered by MedImmune, the global biologics research and development arm of AstraZeneca specializing in antibody and protein therapeutics, at its Cambridge R&D site. The work will utilise MedImmune's considerable experience in developing CHO cell lines engineered for the production of therapeutic mAbs. It will involve characterisation of mAbs across a spectrum of secretion properties, from those which are effectively delivered in growth media to those that are very poorly secreted, often with an increased unfolded protein response and with retention in the cell. The student will employ novel methodologies developed in the laboratory of Professor Kathryn Lilley in the Cambridge Centre for Proteomics (CCP) (http://proteomics.bio.cam.ac.uk/), focussed on the development and application of spatial proteomics methods that aim to accurately locate proteins to subcellular structures on a proteome wide scale 1. Her group has developed other methodologies which determine the components of multi-protein complexes and the spatial context of membrane proteins 2. The outcome from the project will be a better understanding of the mechanisms involved in the secretion of recombinant mAbs, especially in cases where secretion is impaired. Knowing the interacting partners and location of retarded recombinant mAbs will assist in the design of future therapeutic proteins and cell engineering platforms to ensure their efficient secretion. This is of vital importance in the generation of manufacturing cell lines for therapeutic protein production. The successful candidate will be jointly supervised by Prof. Kathryn Lilley of CCP, which is located in the Department of Biochemistry, University of Cambridge, and by science leaders from the Cell Line Development and Engineering team at MedImmune, working alongside a skilled team of scientists in a dynamic biopharmaceutical environment (https://www.medimmune.com/). Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject. BBSRC studentships are available to UK nationals and EU students who meet the UK residency requirements.

Further information about eligibility for Research Council UK funding can be found on the BBSRC website: http://www.bbsrc.ac.uk/documents/studentship-eligibility-pdf/

The successful candidate will receive a stipend paid at RCUK rates for the 4 year duration of the award (£14,296 per annum for 2016-17); fees will be met in full for EU nationals meeting BBSRC residency requirements.

Fixed-term: The funds for this post are available for 4 years in the first instance.

Applications should be sent to Prof. Kathryn Lilley (k.s.lilley@bioc.cam.ac.uk), enclosing a cover letter, a detailed curriculum vitae and the names and contact details of two academic referees. Interviews will be held in March 2017.

1 Christoforou, A. et al. A draft map of the mouse pluripotent stem cell spatial proteome. Nat Commun 7, doi:10.1038/ncomms9992 (2016).

2 Rees, J. S., Lilley, K. S. & Jackson, A. P. SILAC-iPAC: A quantitative method for distinguishing genuine from non-specific components of protein complexes by parallel affinity capture. Journal of Proteomics 115, 143-156, doi:http://dx.doi.org/10.1016/j.jprot.2014.12.006 (2015).

Please quote reference PH11008 on your application and in any correspondence about this vacancy.

PhD studentship in Molecular Microbiology

From Jobs at the University of Cambridge. Published on Feb 10, 2017.

A BBSRC-funded Targeted PhD studentship (for uptake in October 2017) is available in the laboratory of Dr Martin Welch (Department of Biochemistry, Tennis Court Road, Cambridge). The project will investigate the role of an acetate-inducible denitrification pathway in the opportunistic human pathogen, Pseudomonas aeruginosa. Recent RNA-Seq analyses carried out in the lab have revealed that when grown on acetate as a sole carbon source, gene products comprising the Nar/Nir/Nos/Nor denitrification pathways are among the most highly up-regulated transcripts in the cell. This was a surprising observation because transcripts encoding the known regulators of denitrification in P. aeruginosa (Anr and Dnr) were not modulated at all, suggesting that in these conditions, denitrification is controlled by some other mechanism(s). The practical relevance of this is that (i) fatty acids and other acetate-producing substrates are now known to be the preferred energy source for P. aeruginosa during many infection scenarios, and (ii) denitrification is critically-important in industry for microaerobic bacterial growth. Therefore, the key question and the main aim of this project, is to understand why P. aeruginosa turns on the denitrification pathways during growth on acetate, and what regulates this. The successful candidate will investigate this problem using a combined biochemical, genetic and systems-based approach which should provide a rich and varied training opportunity.

The successful applicant will join our Departmental PhD programme and must complete their studies within 4 years. Full funding (covering maintenance, fees and laboratory consumables) is available for UK citizens or EEA students who meet UK residency requirements. In addition to a programme of work in the MW lab, the appointed student will participate in DTP training courses, two 10-week rotation projects (one of which will be based in the MW lab) and a three month internship (PIPS), as well as other DTP-related events.

In the first instance, interested candidates should contact Dr Martin Welch (mw240@cam.ac.uk) with a CV, list of academic referees and a cover letter. Shortlisted candidates will be invited for interview in Cambridge.

Please quote reference PH11425 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Postdoctoral Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Feb 13, 2017.

DNA repair is crucial in all living cells. Unrepaired DNA lesions can terminate gene transcription, leading to mutations, cell death and disease. Repair defects are often linked to cancer and/or progressive neurological disorders (see Khoronenkova & Dianov, PNAS, 2015; Khoronenkova et al., Mol Cell, 2012).

We are looking to recruit a highly motivated and enthusiastic Postdoctoral Research Associate to investigate mechanistic links between deficiencies in the DNA damage response and progressive neurodegenerative diseases. In particular, we are interested in the neurodegenerative phenotype of the multisystem disorder Ataxia Telangiectasia. The project will use differentiation of patient-derived induced pluripotent stem cells, CRISPR/Cas9 editing and state-of-the-art biochemical and proteomic approaches.

The post holder will join the laboratory of Dr Svetlana Khoronenkova at the Department of Biochemistry, University of Cambridge, United Kingdom.

Applicants should have a PhD (DPhil) in Biochemistry or Molecular/Cell Biology and a strong biochemical background. Previous experience in the fields of stem cell biology and/or DNA repair would be an advantage.

For informal enquiries please contact Dr Svetlana Khoronenkova at sk870@cam.ac.uk

Fixed-term: The funds for this post are available for 24 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Any enquires regarding the application process can be directed to Adriana Dote (personnel@bioc.cam.ac.uk).

Please quote reference PH11406 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Postdoctoral Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Jan 24, 2017.

Applications are invited for a Postdoctoral Research Associate position to work with Dr Anna Git at the Department of Biochemistry. The project, funded by Breast Cancer Now, aims to investigate the role of the estrogen receptor in the regulation of the non-coding transcriptome in breast cancer. Dr Git is part of the RNA Labs, a group of research labs investigating various aspects of eukaryotic RNA biology.

Applicants must have a PhD in the biological, biochemical, bioinformatic or biomedical sciences. Candidates with research experience in estrogen receptor biology or in execution/analysis of genome-wide chromatin immunoprecipitation and RNA sequencing are particularly encouraged to apply.

Applications should include a CV, a publication list, details of 3 academic referees and a brief statement outlining key areas of expertise and interest in the topic.

Fixed-term: Funding is available for 2 years in the first instance, with a possible extension of another year. Enquiries from part-time or job-sharing candidates are welcome.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be sent to Dr Anna Git (ag229@cam.ac.uk).

Please quote reference PH11241 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Equality & Diversity