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Vacancies in the Department

Chief Research Laboratory Technician

From Jobs at the University of Cambridge. Published on Jul 20, 2016.

Applications are invited for the post of Chief Research Laboratory Technician to provide technical support for two research groups ¿ one of which being for the Professor of Molecular Microbiology. The research interests of the groups include molecular genetic aspects of bacterial virulence, antibiotic synthesis and resistance mechanisms, bacterial gene regulation mechanisms and protein secretion systems. These research groups are required to operate under strict HSE regulations and a Department of Environment, Food and Rural Affairs (DEFRA) license. The postholder will be responsible for ensuring that all members of the laboratories adhere to these. This will include supervision and monitoring of use and correct disposal of category 2 pathogenic bacterial material on a daily basis.

Ideally, applicants would have skills in molecular microbiology and bacterial genetics and experience in general molecular biology, including recombinant DNA handling techniques. However, enthusiastic and dedicated individuals with skills in general microbiology, biochemistry or genetics are also encouraged to apply as some training will be given. In addition to having excellent technical competence, the successful candidate will be highly motivated and adaptable and will be expected to interact positively and effectively with other members of a large team of postdoctoral and postgraduate research workers, with academics, undergraduates, technicians and administrators plus external bodies such as DEFRA and the HSE.

This key position will be particularly suitable for someone with initiative and drive as it involves diverse and interesting duties. In addition to assisting with research work in the laboratory of the Professor of Microbiology other duties will include the provision of essential backup services for the Professor's research team, including maintenance of chemical, media and microbial stocks, ordering of reagents and equipment, interacting with company representatives, some financial, budgeting duties and maintenance of records on genetic engineering and health and safety issues.

Minimum qualifications for the role are an HNC/D or equivalent in a biological science and appropriate laboratory experience in the areas described above. Experience of working within a DEFRA licensed lab is preferred but training will be provided if necessary.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be directed to Alison Drew - amr70@cam.ac.uk - any enquiries relating to the application process please contact the Personnel secretary - personnel@bioc.cam.ac.uk

Please quote reference PH09676 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Database Manager and Software Developer (Fixed Term)

From Jobs at the University of Cambridge. Published on Jul 25, 2016.

This is a senior position in a multi-institutional research programme that also involves collaborations with a number of companies in the biotechnology and chemicals fields. The post involves the establishment of systems to allow all collaborating partners to exchange and access data; the establishment of common data and metadata standards and monitoring compliance with those standards; the construction and maintenance of the Project database; construction and development of software tools for data analysis and integration, and the development of a formal computer-modelling system that will allow predictive and real-time control of biological processes.

The post-holder will also be responsible for the training of researchers in all collaborating universities to enable them to employ these tools in the joint research programme.

The successful applicant will have both Bachelors and PhD degrees in Computer Science/Engineering, with at least 10 years post-doctoral experience. They should have a strong publication record in both journals and refereed conference proceedings, and extensive experience in a teaching or training capacity. Most importantly, the successful applicant should have a deep understanding of the Petri Nets modelling formalism, experience of its application to modelling biological systems, and a proven ability to construct models that can deal with uncertainty and regulation in models of microbial metabolism and macromolecular synthesis.

Fixed-term: The funds for this post are available until 30 September 2017 in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be directed to Professor Steve Oliver - sgo24@cam.ac.uk

Any enquires regarding the application process can be directed to Steph Favrin - personnel@bioc.cam.ac.uk

Please quote reference PH09720 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

EU Marie-Curie PhD Studentship in Single Cell Analysis in Droplet Microcompartments

From Jobs at the University of Cambridge. Published on Jul 15, 2016.

PhD Studentship in the Marie Curie Network on Nucleic Acid Manipulation for Biological Intervention MMBio.

A graduate studentship leading to the award of a PhD is available from 1 January 2017 (or later) to work at at Cambridge University in the Biochemistry Department (with Dr. F. Hollfelder - http://www.bioc.cam.ac.uk/hollfelder). The studentship is part of the EU Marie-Curie network MMBio (http://www.bioc.cam.ac.uk/hollfelder/Research/mmbio) on Nucleic Acid Manipulation for Biological Intervention.

Cell-based assays are the workhorse assays in fundamental and applied cell biological research. We want to radically miniaturise cell culture to the picolitre scale by compartmentalizing single cells in water-in-oil emulsion droplets (diameters 10-60 µm, formed in microfluidic devices). We have developed arrays of thousands of droplets in which the morphology of cells can be optically interrogated as a function of external stimuli. Analysis at the single cell level resolves cell heterogeneity, e.g. allows the interrogation of minority populations. We use this set-up to study processes of cell-differentiation, gastrulation and reprogramming and gain mechanistic insights.

Candidates will be working in the Biochemistry Department of Cambridge University. Extended secondments in the labs of the academic and industrial network partners (http://www.bioc.cam.ac.uk/hollfelder/Research/mmbio/mmbiofront#partner) are also envisaged. All students take part in a training programme that includes workshops, meetings and courses given by all participant of MMBio.

Applicants should have a first (or upper second) class degree in microengineering, applied physics or cell biology. Specific skills in microfluidic chip design, soft lithography, and familiarity with optical techniques to image and analyse cellular behaviour are advantages.

The salary will comprise a living allowance of €44895.96 and a mobility allowance of €7200.00. An additional allowance may be payable but is dependent on individual family circumstances.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Applications should contain a description of your research interests (e.g. as part of the cover letter) and your detailed CV (with exam marks and all relevant practical experience). Please also include the names and email-addresses of at least two referees, who know you from your courses or laboratory research work.

Send your application by 10 August 2016 by email to studentships@bioc.cam.ac.uk

Please quote reference PH09635 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

EU Marie-Curie PhD Studentship in Synthetic Biology, Directed Protein Evolution and Enzymology (Fixed Term)

From Jobs at the University of Cambridge. Published on Jul 15, 2016.

PhD Studentship in Directed Evolution and Protein Engineering - Marie Curie Network on Nucleic Acid Manipulation for Biological Intervention

MedImmune and Department of Biochemistry, University of Cambridge

A graduate studentship leading to the award of a PhD is available from 1 January 2017 (or later) to work at MedImmune Cambridge (with Dr. M. Snaith) and at Cambridge University in the Biochemistry Department (with Dr. F. Hollfelder - http://www.bioc.cam.ac.uk/hollfelder). The studentship is part of the EU Marie-Curie network MMBio (http://www.bioc.cam.ac.uk/hollfelder/Research/mmbio) on Nucleic Acid Manipulation for Biological Intervention.

Genome editing is revolutionising our ability to study gene function, as well as treating diseases. Engineered nucleases, able to efficiently target defined DNA loci, are key reagents in genome editing. The objective of this PhD project is to develop strategies to alter and retune the activity of genome editing enzymes such as CRISPR-Cas by mechanistic and structural analysis, and also by directed evolution. Ultimately we want to create new enzyme reagents that facilitate the construction of transgenic models of disease and in gene therapy.

Candidates will be based in Cambridge working at the global research centre of MedImmune/AstraZeneca and in the Biochemistry Department of Cambridge University. Extended secondments in the labs of the academic and industrial network partners (http://www.bioc.cam.ac.uk/hollfelder/Research/mmbio/mmbiofront#partner) are also envisaged. All students take part in a training programme that includes workshops, meetings and courses.

Applicants should have a first (or upper second) class degree in biochemistry, biotechnology, chemistry or a related, relevant subject. Specific skills in protein engineering, directed evolution, enzymology, and familiarity with molecular biology techniques (e.g. cloning, DNA manipulation, preparation and handling of DNA libraries) are advantages.

The salary will comprise a living allowance of €44895.96 and a mobility allowance of €7200.00. An additional allowance may be payable but is dependent on individual family circumstances.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Applications should contain a description of your research interests (e.g. as part of the cover letter) and your detailed CV (with exam marks and all relevant practical experience). Please also include the names and email-addresses of at least two referees, who know you from your courses or laboratory research work.

Send your application by 10 August 2016 by email to studentships@bioc.cam.ac.uk

Please quote reference PH09633 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

EU Marie-Curie PhD Studentship in Synthetic Biology, Directed Protein Evolution and Enzymology (Fixed Term)

From Jobs at the University of Cambridge. Published on Jul 15, 2016.

PhD Studentship in Directed Evolution and Protein Engineering - Marie Curie Network on Nucleic Acid Manipulation for Biological Intervention

MedImmune and Department of Biochemistry, University of Cambridge

A graduate studentship leading to the award of a PhD is available from 1 January 2017 (or later) to work at Cambridge University in the Biochemistry Department (with Dr. F. Hollfelder - http://www.bioc.cam.ac.uk/hollfelder). The studentship is part of the EU Marie-Curie network MMBio (http://www.bioc.cam.ac.uk/hollfelder/Research/mmbio) on Nucleic Acid Manipulation for Biological Intervention.

The project will involve the directed evolution of enzymes (phosphatases, kinases and polymerases) in microfluidic droplets, a powerful ultrahigh throughput format that makes selections from million-membered libraries possible. Kinetic and structural analysis will help to delineate the chemical and evolutionary mechanisms that allow the emergence of new and improved activities. Of particular interest are versatile, mechanistically promiscuous catalysts that have multiple activities.

Candidates will be based in the Biochemistry Department of Cambridge University. Extended secondments in the labs of the academic and industrial network partners (http://www.bioc.cam.ac.uk/hollfelder/Research/mmbio/mmbiofront#partner) are also envisaged. All students take part in a training programme that includes workshops, meetings and courses.

Applicants should have a first (or upper second) class degree in biochemistry, biotechnology, chemistry or a related, relevant subject. Specific skills in protein engineering, directed evolution, enzymology, and familiarity with molecular biology techniques (e.g. cloning, DNA manipulation, preparation and handling of DNA libraries) are advantages.

The salary will comprise a living allowance of € 44895.96 and a mobility allowance of €7200.00. An additional allowance may be payable but is dependent on individual family circumstances.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Applications should contain a description of your research interests (e.g. as part of the cover letter) and your detailed CV (with exam marks and all relevant practical experience). Please also include the names and email-addresses of at least two referees, who know you from your courses or laboratory research work.

Send your application by 10 August 2016 by email to studentships@bioc.cam.ac.uk

Please quote reference PH09637 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

EU Marie-Curie PhD Studentship: Directed Protein Evolution for Synthetic Biology and Biocatalysis (Fixed Term)

From Jobs at the University of Cambridge. Published on Jul 15, 2016.

A graduate studentship leading to the award of a PhD is available from 1 January 2017 (or later) to work at Cambridge University in the Biochemistry Department (with Dr. F. Hollfelder - http://www.bioc.cam.ac.uk/hollfelder). The studentship is in the context of the EU Marie-Curie network ES-Cat (http://www.bioc.cam.ac.uk/hollfelder/Research/es-cat) on Directed Protein Evolution for Synthetic Biology and Biocatalysis.

Efficient exploration of sequence space requires new technologies that connect genotype and phenotype. Using droplet compartmentalization we have developed systems in which evolution of binders (e.g. SNAP-display) or catalysts in possible completely in vitro. These powerful technologies will be further developed, to select functional proteins from large libraries, so that they have programmed binding and recognition properties.
Candidates will be mainly based in the Biochemistry Department (in central Cambridge), but also work for extended secondments in the labs of the academic and industrial network partners (http://www.bioc.cam.ac.uk/hollfelder/Research/es-cat/es-catfront#partnerlist). All students take part in a training programme that includes workshops, meetings and courses given by all network partners.

Applicants should have a first (or upper second) class degree in biochemistry, biotechnology, chemistry or a related, relevant subject. Specific skills in protein engineering, directed evolution, chemical and kinetic analysis of enzyme mechanisms and familiarity with molecular biology techniques (e.g. phage or ribosome display, cloning, DNA manipulation, preparation and handling of DNA libraries) are advantages.

The salary will comprise a living allowance of €44895.96 and a mobility allowance of €7200.00. An additional allowance may be payable but is dependent on individual family circumstances.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Applications should contain a description of your research interests (e.g. as part of the cover letter) and your detailed CV (with exam marks and all relevant practical experience). Please also include the names and email-addresses of at least two referees, who know you from your courses or laboratory research work.

Send your application by 10 August 2016 by email to studentships@bioc.cam.ac.uk

Please quote reference PH09634 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Post-doctoral Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Jul 11, 2016.

Applications are invited for a Post-doctoral Research Associate position in the group of Professor Paul Dupree, Department of Biochemistry, University of Cambridge, to study plant cell wall polysaccharide engineering.

The position is part of the OpenPlant project (http://openplant.org/). OpenPlant is a BBSRC-EPSRC funded Synthetic Biology Research Centre. It is a collaboration between the University of Cambridge, the John Innes Centre and The Sainsbury Laboratory Norwich in the United Kingdom. The successful candidate will benefit from participating in a vibrant network of scientists in all three institutes.

The research group of Paul Dupree is interested in the synthesis and function of plant cell wall polysaccharides. We now understand some of the machinery involved in the synthesis of xylan and glucomannan, the two main hemicelluloses of secondary cell walls of plants. This project aims to develop tools, identify enzymes and improve understanding so that we are able to engineer xylan and glucomannan structures in plants. The longer term goal is to be able to engineer polysaccharides for improved properties and applications of plant cell walls for timber, paper, agriculture, animal feed and human food.

Candidates must have, or be close to completing, a PhD in Plant Biochemistry, Plant Biotechnology, or related field. Knowledge of plant cell wall synthesis, polysaccharide analysis and Arabidopsis as a model system is essential. Previous experience with polysaccharide hydrolase heterologous expression and use, HPAEC monosaccharide analysis, PACE and synthetic biology is desirable. Proficiency in sequence analysis, expression construct preparation and confocal fluorescence microscopy is also required.

The successful candidate will conduct research and also write up their research work for presentation and publication. The post holder may be required to assist in the supervision of student projects, provide instructions to students and deliver seminars relating to their research area.

Good communication skills are essential as the post holder will need to work well in a team and collaborate with other researchers. Candidates would ideally have published or submitted papers in this area.

Fixed-term: The funds for this post are available for 3 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be made to Professor Paul Dupree - pd101@cam.ac.uk

Please quote reference PH09575 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Post-doctoral Research Associate in Ultrahigh-throughput Exploration of Metagenomic Libraries (Fixed Term)

From Jobs at the University of Cambridge. Published on Jun 28, 2016.

There is a second postdoctoral position (the first position has been advertised) available for 12 months (with a possibility of extension) from 1 August 2016 (or later) to work with Florian Hollfelder on ultrahigh-throughput exploration of metagenomics libraries. Metagenomes comprise enormous reservoirs coding for proteins with useful activities, but harvesting this potential is difficult, because useful candidates are rare and hidden in an overwhelming majority of irrelevant genes. Traditionally screening campaigns of metagenomic libraries thus have required massive capital-expenditure for robotic systems and much manpower, making them expensive, slow and available to very few users.

We have just shown (Colin et al. Nature Communications 2015, 6:10008. doi: 10.1038/ncomms10008) that exploration and exploitation of the metagenome is accelerated and made more successful by ultrahigh-throughput screening in picoliter droplets: allowing throughput of tens of millions of assays per hour, at dramatically lower cost (and work!) per assay. We now want to use this platform technology to identify enzymes for biosynthesis of therapeutic small molecules, for green bioenergy conversion, bioremediation, food chemistry and other industrial applications. The postdoc project involves establishment of suitable assays for these tasks in microdroplet format, building environmental metagenomics libraries and looking for new catalysts that are then characterised mechanistically and structurally.

Candidates with a background (and published track record) in protein engineering, mechanistic enzymology, organic synthesis and microfluidic engineering are highly desirable. Candidates must hold (or be in the final stages of completing) a PhD in a relevant discipline.

The work is part of the EU Project 'Metafluidics' that involves collaborations with companies and academic groups in Spain, Denmark, Norway, France, Portugal and the UK.

Fixed-term: The funds for this post are available for 1 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be made to Dr Florian Hollfelder -fh111@cam.ac.uk

Please quote reference PH09435 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate: Novel analgesics based on antagonism of TRPV1-AKAP binding (Fixed Term)

From Jobs at the University of Cambridge. Published on Jul 14, 2016.

A postdoctoral research associate or research assistant position is available for a joint BBSRC-funded project between Dr Katherine Stott of the Department of Biochemistry, University of Cambridge, and Prof Peter McNaughton, of King's College London. Please note that this position will be located in University of Cambridge space on the GlaxoSmithKline Open Innovation campus, Stevenage.

The aim of the work is to develop novel analgesics that will act by preventing the interaction between the TRPV1 ion channel and a scaffolding protein named AKAP79. Previous work in our labs has identified this binding site as an important analgesic drug target, and the aim of the project is now to enhance our knowledge of the structure of the site, and then to employ this knowledge to develop novel peptides that can be tested in animal models of human pain conditions. Thus the project spans the whole range from structural biology through to drug development.

For this research associate or research assistant position we will study the efficacy of peptides that can interrupt the TRPV1-AKAP79 interaction as novel analgesics. An essential requirement is extensive experience in the use of animal models of human painful conditions, and expertise with models of neuropathic pain and painful diabetic neuropathy would be an advantage. We will fill this post at either the postdoctoral research associate or the research assistant level, depending on the skills and qualifications of the successful applicant.

The post-holder will work mainly with Christina Hanack and Peter McNaughton in the Stevenage Bioscience Catalyst (SBC) building, located in University of Cambridge space on the GlaxoSmithKline Open Innovation campus, Stevenage, but will also work on other aspects of the project (see separate advertisements) and will need to travel on a regular basis to Cambridge (travel will be reimbursed).

Fixed-term: The funds for this post are available for 2 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Applicants should submit a CV with list of relevant publications, a cover letter explaining why they are suitable for the position and the contact details of at least two referees.

Informal enquiries can be made to either Katherine Stott at ks123@cam.ac.uk or Peter McNaughton at peter.mcnaughton@kcl.ac.uk.

Please quote reference PH09026 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Senior Secretary (Systems Biology)

From Jobs at the University of Cambridge. Published on Jul 25, 2016.

A Senior Secretary is required to provide administrative and secretarial assistance to the Professor of Systems Biology and Biochemistry within the Department of Biochemistry. This is an extremely busy position, with the role-holder facilitating the activities of the Professor, his Research Team, and the Cambridge Systems Biology Centre. In addition the role-holder will act as administrator for the Part III Systems Biology course.

The ideal candidate will be self-motivated, reliable and well organised. You will have excellent communication and organisational skills and a flexible approach to work. Good IT skills, with experience of using Word, Excel, Outlook and PowerPoint etc., will be essential. Knowledge of degree-level science would be advantage as would experience of working in a HE environment, albeit, an ability to work independently and to take initiative in making decisions is more important, as training will be given where needed.

You must have proven experience of working at the level of Senior Secretary/PA and hold qualifications of RSA Grade III or equivalent.

Previous applicants need not apply as you will be considered along with all future applicants.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be directed to Steph Favrin - personnel@bioc.cam.ac.uk.

Please quote reference PH09488 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.