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Vacancies in the Department

Post-doctoral Research Associate in Ultrahigh-throughput Exploration of Metagenomic Libraries (Fixed Term)

From Jobs at the University of Cambridge. Published on Jun 28, 2016.

There is a second postdoctoral position (the first position has been advertised) available for 12 months (with a possibility of extension) from 1 August 2016 (or later) to work with Florian Hollfelder on ultrahigh-throughput exploration of metagenomics libraries. Metagenomes comprise enormous reservoirs coding for proteins with useful activities, but harvesting this potential is difficult, because useful candidates are rare and hidden in an overwhelming majority of irrelevant genes. Traditionally screening campaigns of metagenomic libraries thus have required massive capital-expenditure for robotic systems and much manpower, making them expensive, slow and available to very few users.

We have just shown (Colin et al. Nature Communications 2015, 6:10008. doi: 10.1038/ncomms10008) that exploration and exploitation of the metagenome is accelerated and made more successful by ultrahigh-throughput screening in picoliter droplets: allowing throughput of tens of millions of assays per hour, at dramatically lower cost (and work!) per assay. We now want to use this platform technology to identify enzymes for biosynthesis of therapeutic small molecules, for green bioenergy conversion, bioremediation, food chemistry and other industrial applications. The postdoc project involves establishment of suitable assays for these tasks in microdroplet format, building environmental metagenomics libraries and looking for new catalysts that are then characterised mechanistically and structurally.

Candidates with a background (and published track record) in protein engineering, mechanistic enzymology, organic synthesis and microfluidic engineering are highly desirable. Candidates must hold (or be in the final stages of completing) a PhD in a relevant discipline.

The work is part of the EU Project 'Metafluidics' that involves collaborations with companies and academic groups in Spain, Denmark, Norway, France, Portugal and the UK.

Fixed-term: The funds for this post are available for 1 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be made to Dr Florian Hollfelder -fh111@cam.ac.uk

Please quote reference PH09435 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Senior Secretary (Systems Biology)

From Jobs at the University of Cambridge. Published on Jun 28, 2016.

A Senior Secretary is required to provide administrative and secretarial assistance to the Professor of Systems Biology and Biochemistry within the Department of Biochemistry. This is an extremely busy position, with the role-holder facilitating the activities of the Professor, his Research Team, and the Cambridge Systems Biology Centre. In addition the role-holder will act as administrator for the Part III Systems Biology course.

The ideal candidate will be self-motivated, reliable and well organised. You will have excellent communication and organisational skills and a flexible approach to work. Good IT skills, with experience of using Word, Excel, Outlook and PowerPoint etc., will be essential. Knowledge of degree-level science would be advantage as would experience of working in a HE environment, albeit, an ability to work independently and to take initiative in making decisions is more important, as training will be given where needed.

You must have proven experience of working at the level of Senior Secretary/PA and hold qualifications of RSA Grade III or equivalent.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be made to Steph Favrin - personnel@bioc.cam.ac.uk.

Please quote reference PH09488 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.